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Device Therapy for Left Ventricular Dysfunction

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Device Therapy in Heart Failure

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

Pharmacotherapeutic interventions are proven to reduce symptoms and improve survival in patients with heart failure due to left ventricular dysfunction. The primary target of these medical interventions has been reverse remodeling. Creating a smaller ventricular cavity with improved contractility that is more conical and less spherical in shape has represented a reasonable surrogate of efficacy for effective drug interventions. This chapter reviews the medical devices that are designed to “reverse remodel” the heart, including tethers, socks, and cardiac support devices.

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References

  1. Cohn JN. New therapeutic strategies for heart failure: left ventricular remodeling as a target. J Card Fail 2004; 10(6 Suppl):S200–S201.

    Article  PubMed  Google Scholar 

  2. Bardy GH, Lee KL, Mark DB, Poole JE, Packer DL, Boineau R, et al. Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med 2005; 352(3):225–237.

    Article  CAS  PubMed  Google Scholar 

  3. Bristow MR, Feldman AM, Saxon LA. Heart failure management using implantable devices for ventricular resynchronization: Comparison of Medical Therapy, Pacing, and Defibrillation in Chronic Heart Failure (COMPANION) trial. COMPANION Steering Committee and COMPANION Clinical Investigators. J Card Fail 2000; 6(3):276–285.

    Article  CAS  PubMed  Google Scholar 

  4. Mann DL. Basic mechanisms of left ventricular remodeling: the contribution of wall stress. J Card Fail 2004; 10(6 Suppl):S202–S206.

    Article  CAS  PubMed  Google Scholar 

  5. Force T, Michael A, Kilter H, Haq S. Stretch-activated pathways and left ventricular remodeling. J Card Fail 2002; 8(6 Suppl):S351–S358.

    Article  CAS  PubMed  Google Scholar 

  6. Lietz K, Long JW, Kfoury AG, Slaughter MS, Silver MA, Milano CA, et al. Outcomes of left ventricular assist device implantation as destination therapy in the post-REMATCH era: implications for patient selection. Circulation 2007; 116(5):497–505.

    Article  PubMed  Google Scholar 

  7. Long JW, Kfoury AG, Slaughter MS, Silver M, Milano C, Rogers J, et al. Long-term destination therapy with the HeartMate XVE left ventricular assist device: improved outcomes since the REMATCH study. Congest Heart Fail 2005; 11(3):133–138.

    Article  PubMed  Google Scholar 

  8. Stevenson LW, Miller LW, Svigne-Nickens P, Ascheim DD, Parides MK, Renlund DG, et al. Left ventricular assist device as destination for patients undergoing intravenous inotropic therapy: a subset analysis from REMATCH (Randomized Evaluation of Mechanical Assistance in Treatment of Chronic Heart Failure). Circulation 2004; 110(8):975–981.

    Article  PubMed  Google Scholar 

  9. Miller LW, Pagani FD, Russell SD, John R, Boyle AJ, Aaronson KD, et al. Use of a continuous-flow device in patients awaiting heart transplantation. N Engl J Med 2007; 357(9):885–896.

    Article  CAS  PubMed  Google Scholar 

  10. Nose Y. FDA approval of totally implantable permanent total artificial heart for humanitarian use. Artif Organs 2007; 31(1):1–3.

    Article  PubMed  Google Scholar 

  11. Acker MA. Surgical therapies for heart failure. J Card Fail 2004; 10(6 Suppl): S220–S224.

    Article  PubMed  Google Scholar 

  12. De BM, Alfieri O. Surgical methods to reverse left ventricular remodeling. Curr Heart Fail Rep 2007; 4(4):214–220.

    Article  Google Scholar 

  13. Athanasuleas CL, Buckberg GD, Stanley AW, Siler W, Dor V, Di DM, et al. Surgical ventricular restoration in the treatment of congestive heart failure due to post-infarction ventricular dilation. J Am Coll Cardiol 2004; 44(7):1439–1445.

    Article  PubMed  Google Scholar 

  14. Batista RJ, Verde J, Nery P, Bocchino L, Takeshita N, Bhayana JN, et al. Partial left ventriculectomy to treat end-stage heart disease. Ann Thorac Surg 1997; 64(3): 634–638.

    Article  CAS  PubMed  Google Scholar 

  15. Batista RJ, Santos JL, Takeshita N, Bocchino L, Lima PN, Cunha MA. Partial left ventriculectomy to improve left ventricular function in end-stage heart disease. J Card Surg 1996; 11(2):96–97.

    Article  CAS  PubMed  Google Scholar 

  16. Mccarthy JF, McCarthy PM, Starling RC, Smedira NG, Scalia GM, Wong J, et al. Partial left ventriculectomy and mitral valve repair for end-stage congestive heart failure. Eur J Cardiothorac Surg 1998; 13(4):337–343.

    Article  CAS  PubMed  Google Scholar 

  17. Carraway EA, Rayburn BK. Device therapy for remodeling in congestive heart failure. Curr Heart Fail Rep 2007; 4(1):53–58.

    Article  PubMed  Google Scholar 

  18. Hamner C, Ruth G, Raffe M, Schoen FJ, Schaff H. Safety and biocompatibility of the Myosplint system – a passive implantable device that alters ventricular geometry for the treatment of heart failure. ASAIO J 2004; 50(5):438–443.

    Article  PubMed  Google Scholar 

  19. Grossi EA, Saunders PC, Woo YJ, Gangahar DM, Laschinger JC, Kress DC, et al. Intraoperative effects of the coapsys annuloplasty system in a randomized evaluation (RESTOR-MV) of functional ischemic mitral regurgitation. Ann Thorac Surg 2005; 80(5):1706–1711.

    Article  PubMed  Google Scholar 

  20. Burkhoff D, Wechsler AS. Surgical ventricular remodeling: a balancing act on systolic and diastolic properties. J Thorac Cardiovasc Surg 2006; 132(3):459–463.

    Article  PubMed  Google Scholar 

  21. Sabbah HN. Global left ventricular remodeling with the Acorn Cardiac Support Device: hemodynamic and angiographic findings in dogs with heart failure. Heart Fail Rev 2005; 10(2):109–115.

    Article  PubMed  Google Scholar 

  22. Sabbah HN, Sharov VG, Gupta RC, Mishra S, Rastogi S, Undrovinas AI, et al. Reversal of chronic molecular and cellular abnormalities due to heart failure by passive mechanical ventricular containment. Circ Res 2003; 93(11):1095–1101.

    Article  CAS  PubMed  Google Scholar 

  23. Starling RC, Jessup M, Oh JK, Sabbah HN, Acker MA, Mann DL, et al. Sustained benefits of the CorCap Cardiac Support Device on left ventricular remodeling: three year follow-up results from the Acorn clinical trial. Ann Thorac Surg 2007; 84(4): 1236–1242.

    Article  PubMed  Google Scholar 

  24. Mann DL, Acker MA, Jessup M, Sabbah HN, Starling RC, Kubo SH. Clinical evaluation of the CorCap Cardiac Support Device in patients with dilated cardiomyopathy. Ann Thorac Surg 2007; 84(4):1226–1235.

    Article  PubMed  Google Scholar 

  25. Acker MA, Bolling S, Shemin R, Kirklin J, Oh JK, Mann DL, et al. Mitral valve surgery in heart failure: insights from the Acorn Clinical Trial. J Thorac Cardiovasc Surg 2006; 132(3):568–77, 577.

    Google Scholar 

  26. Mann DL, Acker MA, Jessup M, Sabbah HN, Starling RC, Kubo SH. Rationale, design, and methods for a pivotal randomized clinical trial for the assessment of a cardiac support device in patients with New York health association class III–IV heart failure. J Card Fail 2004; 10(3):185–192.

    Article  PubMed  Google Scholar 

  27. Sabbah HN. Global left ventricular remodeling with the Acorn Cardiac Support Device: hemodynamic and angiographic findings in dogs with heart failure. Heart Fail Rev 2005; 10(2):109–115.

    Article  PubMed  Google Scholar 

  28. Rastogi S, Gupta RC, Mishra S, Morita H, Tanhehco EJ, Sabbah HN. Long-term therapy with the acorn cardiac support device normalizes gene expression of growth factors and gelatinases in dogs with heart failure. J Heart Lung Transplant 2005; 24(10):1619–1625.

    Article  PubMed  Google Scholar 

  29. Sabbah HN, Sharov VG, Gupta RC, Mishra S, Rastogi S, Undrovinas AI, et al. Reversal of chronic molecular and cellular abnormalities due to heart failure by passive mechanical ventricular containment. Circ Res 2003; 93(11):1095–1101.

    Article  CAS  PubMed  Google Scholar 

  30. Sabbah HN. Effects of cardiac support device on reverse remodeling: molecular, biochemical, and structural mechanisms. J Card Fail 2004; 10(6 Suppl):S207–S214.

    Article  CAS  PubMed  Google Scholar 

  31. Magovern JA. Experimental and clinical studies with the Paracor cardiac restraint device. Semin Thorac Cardiovasc Surg 2005; 17(4):364–368.

    Article  PubMed  Google Scholar 

  32. Bolling SF, Pagani FD, Deeb GM, Bach DS. Intermediate-term outcome of mitral reconstruction in cardiomyopathy. J Thorac Cardiovasc Surg 1998; 115(2):381–386.

    Article  CAS  PubMed  Google Scholar 

  33. Wu AH, Aaronson KD, Bolling SF, Pagani FD, Welch K, Koelling TM. Impact of mitral valve annuloplasty on mortality risk in patients with mitral regurgitation and left ventricular systolic dysfunction. J Am Coll Cardiol 2005; 45(3):381–387.

    Article  PubMed  Google Scholar 

  34. McGee EC, Gillinov AM, Blackstone EH, Rajeswaran J, Cohen G, Najam F, et al. Recurrent mitral regurgitation after annuloplasty for functional ischemic mitral regurgitation. J Thorac Cardiovasc Surg 2004; 128(6):916–924.

    PubMed  Google Scholar 

  35. Feldman T, Wasserman HS, Herrmann HC, Gray W, Block PC, Whitlow P, et al. Percutaneous mitral valve repair using the edge-to-edge technique: six-month results of the EVEREST Phase I Clinical Trial. J Am Coll Cardiol 2005; 46(11):2134–2140.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Cardiothoracic Transplantation, Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX, USA

    Clyde W. Yancy MD

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  1. Clyde W. Yancy MD
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Editor information

Editors and Affiliations

  1. Beth Israel Deaconess Medical Center, Harvard Medical School, Pilgrim Road 185, Boston, 02215, U.S.A.

    William H. Maisel

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© 2010 Humana Press, a part of Springer Science+Business Media, LLC

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Yancy, C.W. (2010). Device Therapy for Left Ventricular Dysfunction. In: Maisel, W. (eds) Device Therapy in Heart Failure. Contemporary Cardiology. Humana Press. https://doi.org/10.1007/978-1-59745-424-7_14

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  • DOI: https://doi.org/10.1007/978-1-59745-424-7_14

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-994-9

  • Online ISBN: 978-1-59745-424-7

  • eBook Packages: MedicineMedicine (R0)

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