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Circadian Rhythm Disorders

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Primary Care Sleep Medicine

Part of the book series: Current Clinical Practice ((CCP))

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Abstract

Simply stated, everyday people should strive to fall asleep at the time when they are sleepiest. For most people this means having the major sleep period start in the evening and conclude at dawn. However, situations arise in which a person’s sleep timing, or circadian rhythm of sleep, is not synchronized with other factors, potentially leading to sleep quality problems. The term circadian refers to a circuit or period that is about 24 hours long. Many physiological, biochemical, and behavioral activities have a circadian rhythm, with the sleep-wake cycle being the most easily recognized. The sleep-wake cycle is related to other circadian rhythms, such as core body temperature and concentrations of melatonin or cortisol, through a complex interaction of signals.

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References

  1. Campbell S, Murphy P (1998) Extraocular circadian phototransduction in humans. Science 279:396–399.

    Article  PubMed  CAS  Google Scholar 

  2. Czeisler C, Duffy J, Shanahan T, et al. (1999) Stability, precision, and near-24-hour period of the human circadian pacemaker. Science 284:2177–2181.

    Article  PubMed  CAS  Google Scholar 

  3. Naylor E, Bergmann B, Krauski K, et al. (2000) The circadian clock mutation alters sleep homeosta-sis in the mouse. J Neurosci 20:8138–8143.

    PubMed  CAS  Google Scholar 

  4. Toh K, Jones C, He Y, et al. (2001) An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. Science 291:1040–1043.

    Article  PubMed  CAS  Google Scholar 

  5. Hattar S, Lucas RJ, Mrosovsky N, et al. (2003) Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice. Nature 424:75–81.

    Article  CAS  Google Scholar 

  6. Schrader H, Bovim G, Sand T (1993) The prevalence of delayed and advanced sleep phase syndromes. J Sleep Res 2:51–55.

    PubMed  Google Scholar 

  7. Cole R, Smith J, Alcala Y, et al. (2002) Bright-light mask treatment of delayed sleep phase syndrome. J Biol Rhythms 17:89–101.

    Article  PubMed  Google Scholar 

  8. Arendt J, Deacon S, English J, et al. (1995) Melatonin and adjustment to phase shift. J Sleep Res 4:74–79.

    PubMed  Google Scholar 

  9. Kayumov L, Brown G, Jindal R, et al. (2001) A randomized, double-blind, placebo-controlled crossover study of the effect of exogenous melatonin on delayed sleep phase syndrome. Psychosom Med 63:40–418.

    PubMed  CAS  Google Scholar 

  10. Nagtegaal JE, Kerkhof GA, Smits MG, et al. (1998) Delayed sleep phase syndrome: a placebo-controlled cross-over study on the effects of melatonin administered five hours before the individual dim light melatonin onset. J Sleep Res 7:135–143.

    Article  PubMed  CAS  Google Scholar 

  11. Campbell S, Dawson D, Anderson MW (1993) Alleviation of sleep maintenance insomnia withitimed exposure to bright light. J Am Geriatr Soc 41:829–836.

    PubMed  CAS  Google Scholar 

  12. Murphy P, Campbell S (1996) Enhanced performance in elderly subjects following bright light treat-ment of sleep maintenance insomnia. J Sleep Res 5:165–172.

    Article  PubMed  CAS  Google Scholar 

  13. Moldofsky H, Musisi S, Phillipson E (1986) Treatment of a case of advanced sleep phase syndrome by phase advance chronotherapy. Sleep 9:61–65.

    PubMed  CAS  Google Scholar 

  14. De Leersnyder H, Bresson J, de Blois M, et al. (2003) Beta 1-adrenergic antagonists and melatonin reset the clock and restore sleep in a circadian disorder, Smith-Magenis syndrome. J Med Genet 40:74–78.

    Article  PubMed  Google Scholar 

  15. Leger D, Guilleminault C, Santos C, et al. (2002) Sleep/wake cycles in the dark: sleep recorded by polysomnography in 26 totally blind subjects compared to controls. Clin Neurophysiol 113:1607–1614.

    Article  PubMed  Google Scholar 

  16. Lewy A, Bauer V, Hasler B, et al. (2001) Capturing the circadian rhythms of free-running blind people with 0.5 mg melatonin. Brain Res 918:96–100.

    Article  PubMed  CAS  Google Scholar 

  17. Petrie K, Dawson AG, Thompson L, et al. (1993) A double-blind trial of melatonin as a treatment for jet lag in international cabin crew. Biol Psychiatr 33:526–530.

    Article  CAS  Google Scholar 

  18. Spitzer RL, Terman M, Williams JB, et al. (1999) Jet lag: clinical features, validation of a new syndrome-specific scale, and lack of response to melatonin in a randomized, double-blind trial. Am J Psychiatr 156:1392–1396.

    PubMed  CAS  Google Scholar 

  19. Wright S, Lawrence L, Wrenn K, et al. (1998) Randomized clinical trial of melatonin after night-shift work: efficacy and neuropsychologic effects. Ann Emerg Med 32:334–340.

    Article  PubMed  CAS  Google Scholar 

  20. Mohren DC, Jansen NW, Kant IJ, et al. (2002) Prevalence of common infections in employees on different work shifts. J Occup Environ Med 44:1003–1011.

    Article  PubMed  Google Scholar 

  21. Rosekind M, Smith R, Miller D, et al. (1995) Alertness management: strategic naps in operational settings. J Sleep Res 4:62–66.

    Article  PubMed  Google Scholar 

  22. Czeisler CA, Walsh JK, Roth T, et al. (2005) Modafinal for excessive sleepiness associated with shift-work sleep disorder. N Engl J Med 353:476–486.

    Article  PubMed  CAS  Google Scholar 

  23. Nickelsen T, Samel A, Vejvoda M, et al. (2002) Chronobiotic effects of the melatonin agonist LY 156735 following a simulated 9h time shift: results of a placebo-controlled trial. Chronobiol Int 19:915–936.

    Article  PubMed  CAS  Google Scholar 

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© 2007 Humana Press Inc., Totowa, NJ

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Krahn, L.E. (2007). Circadian Rhythm Disorders. In: Pagel, J.F., Pandi-Perumal, S.R. (eds) Primary Care Sleep Medicine. Current Clinical Practice. Humana Press. https://doi.org/10.1007/978-1-59745-421-6_24

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  • DOI: https://doi.org/10.1007/978-1-59745-421-6_24

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-992-5

  • Online ISBN: 978-1-59745-421-6

  • eBook Packages: MedicineMedicine (R0)

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