Skip to main content

Clinical Features, Diagnosis, and Treatment of Narcolepsy

  • Chapter
Primary Care Sleep Medicine

Part of the book series: Current Clinical Practice ((CCP))

  • 1100 Accesses

Abstract

Narcolepsy, a chronic sleep disorder that typically begins at a young age, has the potential to greatly disrupt social, educational, and vocational development. Because of the nature of its symptoms (e.g., excessive daytime sleepiness and cataplexy, in particular), narcolepsy provides insights to mechanisms regarding human sleep regulation. Its universal symptom of inappropriate daytime sleepiness probably contributes most substantially to the resulting impaired quality of life that has been documented (1). A specific and intriguing sign of narcolepsy, experienced by 60% of patients, is cataplexy, or transient muscle weakness triggered by emotions. Other classic, but less specific symptoms include sleep paralysis and hypnagogic hallucinations. Disturbed nocturnal sleep is the most recent addition to the constellation of symptoms.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Broughton R, Guberman A, Roberts J (1984) Comparison of the psychosocial effects of epilepsy and narcolepsy/cataplexy: a controlled study. Epilepsia 25:423–433.

    PubMed  CAS  Google Scholar 

  2. Silber M, Krahn L, Olson E, et al. (2002) The epidemiology of narcolepsy in Olmsted County, Minnesota: a population-based study. Sleep 25:197–202.

    PubMed  Google Scholar 

  3. Aldrich M (1998) Diagnostic aspects of narcolepsy. Neurology 50(Suppl 1):S2–S7.

    PubMed  CAS  Google Scholar 

  4. Krahn L, Black J, Silber M (2001) Narcolepsy: new understanding of irresistible sleep. Mayo Clin Proc 76:185–194.

    Article  PubMed  CAS  Google Scholar 

  5. Krahn L, Hansen M, Shepard J (2001) Pseudocataplexy. Psychosomatics 42:356–358.

    Article  PubMed  CAS  Google Scholar 

  6. Krahn L, Boeve B, Olson E, et al. (2000) A standardized test for cataplexy. Sleep Med 1:125–130.

    Article  PubMed  Google Scholar 

  7. Rubboli G, d’Orse G, Zaniboni A, et al. (2000) A video-polygraphic analysis of the cataplectic attack. Clin Neurophysiol 111(Suppl 2):S120–S128.

    Article  PubMed  Google Scholar 

  8. Shapiro B, Sptiz H (1976) Problems in the differential diagnosis of narcolepsy versus schizophrenia. Am J Psychiatry 133:1321–1323.

    PubMed  CAS  Google Scholar 

  9. Overeem S, Mignot E, Gert van Dijk J, et al. (2001) Narcolepsy: clinical features, new pathophysiologic insights, and future perspectives. J Clin Neurophysiol 18:78–105.

    Article  PubMed  CAS  Google Scholar 

  10. Yoss R, Daly D (1957) Criteria for the diagnosis of the narcoleptic syndrome. Procedural Staff Meeting, Mayo Clinic vol. 32, pp. 320–328.

    CAS  Google Scholar 

  11. Parkes J, Fenton G, Struthers G, et al. (1974) Narcolepsy and cataplexy: clinical features, treatment and cerebrospinal fluid findings. Q J Med 43:525–536.

    PubMed  CAS  Google Scholar 

  12. Mignot E, Hayduk R, Black J, et al. (1997) HLA DQBl*0602 is associated with cataplexy in 509 narcoleptic patients. Sleep 20:1012–1020.

    PubMed  CAS  Google Scholar 

  13. Aldrich M, Chervin R, Malow B (1997) Value of the multiple sleep latency test (MSLT) for the diagnosis of narcolepsy. Sleep 20:620–629.

    PubMed  CAS  Google Scholar 

  14. Scammell T (2003) The neurobiology, diagnosis and treatment of narcolepsy. Ann Neurol 53:154–166.

    Article  PubMed  Google Scholar 

  15. Mignot E, Lammers G, Ripley B, et al. (2002) The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias. Arch Neurol 59:1553–1562.

    Article  PubMed  Google Scholar 

  16. Garma L, Marchand F (1994) Non-pharmacological approaches to the treatment of narcolepsy. Sleep 17:S97–S102.

    PubMed  CAS  Google Scholar 

  17. Mitler M, Harsh J, Hirshkowitz M, et al. (2000) Long-term efficacy and safety of modafinil (Provigil) for the treatment of excessive daily sleepiness associated with narcolepsy. Sleep Med 1:231–243.

    Article  PubMed  Google Scholar 

  18. Larrosa O, de la Llave Y, Bario S, et al. (2001) Stimulant and anticataplectic effects of reboxetine in patients with narcolepsy: a pilot study. Sleep 24:282–285.

    PubMed  CAS  Google Scholar 

  19. Lammers G, Arends J, Declerck A, et al. (1993) Gamma-hydroxybutyrate and narcolepsy: a double blind placebo-controlled study. Sleep 16:216–220.

    PubMed  CAS  Google Scholar 

  20. Reference PD (2004) Xyrem Oral Solution. Orphan Medical, Minnetonka, MN.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Humana Press Inc., Totowa, NJ

About this chapter

Cite this chapter

Krahn, L.E. (2007). Clinical Features, Diagnosis, and Treatment of Narcolepsy. In: Pagel, J.F., Pandi-Perumal, S.R. (eds) Primary Care Sleep Medicine. Current Clinical Practice. Humana Press. https://doi.org/10.1007/978-1-59745-421-6_21

Download citation

  • DOI: https://doi.org/10.1007/978-1-59745-421-6_21

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-992-5

  • Online ISBN: 978-1-59745-421-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics