Summary
• The immune system is centrally involved in the pathogenesis of many rheumatic diseases, although the precise mechanisms by which the immune system becomes diseased remain undefined for most illnesses.
• central theory governing autoimmunity is that disease results when a genetically susceptible individual is exposed to either a self-antigen or foreign antigen, resulting in an aberrant immune response.
• Autoantibody formation is characteristic of many rheumatic illnesses but many of these autoantibodies are not directly pathogenic.
• This chapter provides an overview of immunology and the rheumatic illnesses discussed in this volume, with a focus on autoimmunity.
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References
Reeves WH, Richards HB, Satoh, M. Autoantibodies. In: Lahita R, ed. Textbook of Autoimmunity. Lippincott Williams and Wilkins, Philadelphia PA, 2000, pp. 81–100.
Dziarksi R. Preferential induction of autoantibody secretion in polyclonal activation by peptidoglycan and lipopolysaccharide: in vivo studies. J Immunol 1982;128:1018–1025.
Oldstone MBA. Molecular mimicry and autoimmune disease. Cell 1987;50:819–820.
Plotz PH. Autoantibodies are anti-idiotyope antibodies to antiviral antibodies. Lancet 1983;2:824–826.
Tan EM. Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology. Adv Immunol 1989;44:93–151.
Buyon JL. Systemic Lupus Erythematosus. Clinical and Laboratory Features. In: Klippel JH, ed. Primer on Rheumatic Diseases, 12th Ed. Arthritis Foundation, Atlanta Georgia 2001, pp. 335–346.
Pisetsky DS. Systemic Lupus Erythematosus. Epidemiology, Pathology, and Pathogenesis. In: Klippel JH, ed. Primer on Rheumatic Diseases, 12th Ed. Arthritis Foundation, Atlanta Georgia 2001, pp. 329–335.
Bell M, Askari A, Bokman A, et al. Sjogren’s syndrome: a critical review of clinical management. J Rheumatol 1999;26:2051–2061.
Julkunen H, Siren MK, Kaaja F, Kurki P, Friman C, Koskimies S. Maternal HLA antigens and antibodies to SSA/Ro and SSB/La. Comparison with systemic lupus erythematosus and primary Sjogren’s syndrome. Br J Rheumatol 1995;34:901–907.
Pillimer S. Sjogren’s Syndrome. In: Klippel JH, ed. Primer on Rheumatic Diseases, 12th Ed. Arthritis Foundation, Atlanta Georgia 2001, pp. 377–384.
Gilliland, B. Systemic sclerosis and related disorders. In: Harrison’ On line, chapter 303, McGraw Hill, New York, 2006, http://www.accessmedicine.com/content.aspx?alD=94691
Steen VD. Autoantibodies in systemic sclerosis. Semin Arthritis Rheum 2005;35(1): 35–42.
Tanimoto K, Nakano K, Kano S et al. Classification criteria for the idiopathic inflammatory myopathies. Curr Opin Rheumatol 1997;9:527–535.
Hoffman G, Specks U. Antineutrophil cytoplasmic antibodies. Arthritis Rheum 1998;41:1521–1537.
Keogan MY et al. Activation of normal neutrophils by anti-neutrophil cytoplasmic antibodies. Clin Exp Immunol 1992; 90:228.
Vassilopoulos D, Calabrese LH. Hepatitis C virus infection and vasculitis: Implications of antiviral and immunosuppressive therapies. Arthritis Rheum 2002;46:585.
Van Gaalen FA, van Aken J, Huizinga TW, et al. Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides [CCPs] influences the severity of rheumatoid arthritis. Arthritis Rheum. 2004; 50:2113–2121.
Reveille JD. Seronegative Spondyloarthropathies. In: Klippel JH, ed. Primer on Rheumatic Diseases, 12th Ed. Arthritis Foundation, Atlanta Georgia 2001, pp. 239–245.
Mear JP, Schreiber KL, Munz C, et al. Misfolding of HLA-B27 as a result of itsB pocket suggests a novel mechanism for its role in susceptibility to spondyloarthropathies. J Immunol 1999;163: 6665–6670.
Fox RI, Tornwall J, Michelson P. Current issues in the diagnosis and treatment of Sjogren’s syndrome. Curr Opin Rheumatol 1999; 11:364–371.
Tan FK, Stivers DN, Foster MW, et al. Association of microsatellite markersnear the fibrillin 1 gene on human chromosome 15q and scleroderma in a Native American population. Arthritis Rheum 1998;41:1729–1737.
Reveille JD, Owerbach D, Goldstein R, Moreda R, Isern RA, Arnett FC. Association of polar amino acids at position 26 of the HLA DQB1 first domainwith the anticentromere antibody response in systemic sclerosis. J Clin Invest1992;89:1290–1213.
Wortmann RL. Inflammatory and metabolic diseases of muscle. In: Klippel JH, ed. Primer on Rheumatic Diseases, 12th Ed. Arthritis Foundation, Atlanta Georgia 2001, pp. 369–376.
Weyand CM, Goronzy JJ. Vasculitides. In: Klippel JH, ed. Primer on Rheumatic Diseases, 12th Ed. Arthritis Foundation, Atlanta Georgia 2001, pp. 397–405.
Gregersen PK, Silver J, Winchester RJ. The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 1987;30:1205–1213.
Weyand CM, McCarthy TG, Goronzy JJ. Correlation between disease phenotype and genetic heterogeneity in rheumatoid arthritis. Ann Intern Med 1992;117:801–806.
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Massarotti, E.M. (2008). Overview of Immunology and the Rheumatic Diseases. In: Coleman, L.A. (eds) Nutrition and Rheumatic Disease. Nutrition and Health. Humana Press. https://doi.org/10.1007/978-1-59745-403-2_1
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DOI: https://doi.org/10.1007/978-1-59745-403-2_1
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