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Protozoal Infections

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The Neurological Manifestations of Pediatric Infectious Diseases and Immunodeficiency Syndromes

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References

  1. 1. Boyer KM, McLeod RL. Toxoplasma gondii (Toxoplasmosis) In: Long SS, Pickering LK, Prober CG, eds. Principles and Practice of Pediatric Infectious Diseases. 2nd ed. New York, NY: Churchill Livingstone; 2003; 1303–1322.

    Google Scholar 

  2. American Academy of Pediatrics. Toxoplasma gondii infections. In: Pickering LK, Baker CJ, Long SS, McMillan JA, ed. Red Book: 2006 Report of the Committee on Infectious Diseases. 27th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2006; 666–671.

    Google Scholar 

  3. 3. Remington JS, McLeod R, Thulliez P, Desmonts G. Toxoplasmosis. In: Remington JS, Klein JO, Wilson CB, Baker CJ, eds. Infectious Diseases of the Fetus and Newborn Infant. 6th ed. Philadelphia, PA: Elsevier Saunders; 2006; 947–1091.

    Google Scholar 

  4. 4. Montoya JG, Kovacs JA, Remington JS. Toxoplasma gondii. In: Mandell GL, Bennett JE, Dolin R, eds. Principles and Practice of Infectious Diseases. 6th ed. Philadelphia, PA: Churchill Livingstone; 2005; 3170–3193.

    Google Scholar 

  5. 5. Khan EA, Correa AG. Toxoplasmosis of the central nervous system in non-human immunodeficiency virus-infected children: case report and review of the literature. Pediatr Infect Dis J. 1997; 16:611–618.

    PubMed  CAS  Google Scholar 

  6. 6. Mitchell CD, Erlich SS, Mastrucci MT, Hutto, SC, Parks WP, Scott GB. Congenital toxoplasmosis occurring in infants perinatally infected with human immunodeficiency virus 1. Pediatr Infect Dis J. 1990; 9:512–518.

    PubMed  CAS  Google Scholar 

  7. 7. Lowichik A, Siegel JD. Parasitic infections of the central nervous system in children. Part I: congenital infections and meningoencephalitis. J Child Neurol. 1995; 10:4–17.

    PubMed  CAS  Google Scholar 

  8. 8. Massa G, Vanderschueren-Lodeweyckx M, Van Vliet G, Craen M, de Zegher F, Eggermont E. Hypothalamo-pituitary dysfunction in congenital toxoplasmosis. Eur J Pediatr. 1989; 148:742–744.

    PubMed  CAS  Google Scholar 

  9. 9. McAuley J, Boyer KM, Patel D. et al. Early and longitudinal evaluations of treated infants and children and untreated historical patients with congenital toxoplasmosis: the Chicago Collaborative Treatment Trial. Clin Infect Dis. 1994; 18:38–72.

    PubMed  CAS  Google Scholar 

  10. 10. Wilson CB, Remington JS, Stagno S, Reynolds DW. Development of adverse sequelae in children born with subclinical congenital Toxoplasma infection. Pediatrics. 1980; 66:767–774.

    PubMed  CAS  Google Scholar 

  11. 11. Wallon M, Kodjikian L, Binquet C, et al. Long-term ocular prognosis in 327 children with congenital toxoplasmosis. Pediatrics. 2004; 113:1567–1572.

    PubMed  Google Scholar 

  12. 12. McLeod R, Boyer K, Karrison T, et al. Outcome of treatment for congenital toxoplasmosis, 1981–2004: the National Collaborative Chicago-Based, Congenital Toxoplasmosis Study. Clin Infect Dis. 2006; 42:1383–1394.

    PubMed  Google Scholar 

  13. 13. McCabe RE, Brook RG, Dorfman RF, Remington JS. Clinical spectrum in 107 cases of toxoplasmic lymphadenopathy. Rev Infect Dis. 1987; 9:754–774.

    PubMed  CAS  Google Scholar 

  14. 14. Montoya JG, Remington JS. Toxoplasmic chorioretinitis on the setting of acute acquired toxoplasmosis. Clin Infect Dis. 1996; 23:277–282.

    PubMed  CAS  Google Scholar 

  15. 15. Montoya JG, Jordan R, Lingamneni S, Berry GJ, Remington JS. Toxoplasmic myocarditis and polymyositis in patients with acute acquired toxoplasmosis diagnosed during life. Clin Infect Dis. 1997; 24:676–683.

    PubMed  CAS  Google Scholar 

  16. 16. Israelski DM, Remington JS. Toxoplasmosis in the non-AIDS immunocompromised host. Curr Clin Top Infect Dis. 1993; 13:322–356.

    PubMed  CAS  Google Scholar 

  17. 17. Luft BJ, Remington JS. Toxoplasmic encephalitis in AIDS. Clin Infect Dis. 1992; 15:211–222.

    PubMed  CAS  Google Scholar 

  18. 18. Duzovali O, Choroszy MS, Chan KW. Hyponatremia as the presenting feature of cerebral toxoplasmosis. Bone Marrow Transplantation. 2005; 35:1221–1222.

    PubMed  CAS  Google Scholar 

  19. 19. Gray F, Gherardi R, Wingate E, et al. Diffuse “encephalitic” cerebral toxoplasmosis in AIDS. Report of four cases. J Neurol. 1989; 236:273–277.

    PubMed  CAS  Google Scholar 

  20. 20. Levy RM, Mills CM, Posin JP, Moore SG, Rosenblum ML, Bredesen DE. The efficacy and clinical impact of brain imaging in neurologically symptomatic AIDS patients: a prospective CT/MRI study. J Acquir Immune Defic Syndr. 1990; 3:461–471.

    PubMed  CAS  Google Scholar 

  21. 21. Mueller-Mang C, Mang TG, Kalhs P, Thurnher MM. Imaging characteristics of toxoplasmosis encephalitis after bone marrow transplantation: report of two cases and review of literature. Neuroradiology. 2006; 48:84–89.

    PubMed  CAS  Google Scholar 

  22. 22. Willis MS, Southern P, Latimer MJ. Toxoplasma infections: making the best use of laboratory tests. Infect Med. 2002; 19:522–532.

    Google Scholar 

  23. 23. Boyer KM. Diagnostic testing for congenital toxoplasmosis. Pediatr Infect Dis J. 2001; 20:59–60.

    PubMed  CAS  Google Scholar 

  24. 24. Montoya JG. Laboratory diagnosis of Toxoplasma gondii infection and toxoplasmosis. J Infect Dis. 2002; 185 (Suppl 1):S73–82.

    PubMed  Google Scholar 

  25. 25. Naessens A, Jenum PA, Pollak A, et al. Diagnosis of congenital toxoplasmosis in the neonatal period: a multicenter evaluation. J Pediatr. 1999; 135:714–719.

    PubMed  CAS  Google Scholar 

  26. 26. Boyer KM. Congenital toxoplasmosis: current status of diagnosis, treatment, and prevention. Semin Pediatr Infect Dis. 2000; 11:165–171.

    Google Scholar 

  27. 27. American Academy of Pediatrics. Malaria. In: Pickering LK, Baker CJ, Long SS, McMillan JA, eds. Red Book: 2006 Report of the Committee on Infectious Diseases. 27th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2006; 435–441.

    Google Scholar 

  28. WHO. Guidelines for the Treatment of Malaria. Geneva, Switzerland: World Health Organization; 2006.

    Google Scholar 

  29. 29. Gubler DJ. Resurgent vector-borne diseases as a global health problem. Emerg Infect Dis. 1998; 4:442–450.

    PubMed  CAS  Google Scholar 

  30. Centers for Disease Control and Prevention (CDC). Local transmission of Plasmodium vivax malaria—Palm Beach County, Florida, 2003. MMWR. 2003; 52:908–911.

    Google Scholar 

  31. Centers for Disease Control and Prevention (CDC). Multifocal autochthonous transmission of malaria—Florida, 2003. MMWR. 2004; 53:412–413.

    Google Scholar 

  32. 32. Zucker JR. Changing patterns of autochthonous malaria transmission in the United States: a review of recent outbreaks. Emerg Infect Dis. 1996; 2:37–43.

    PubMed  CAS  Google Scholar 

  33. 33. Isaacson M. Airport malaria: a review. Bull World Health Organ. 1989; 67:737–743.

    PubMed  CAS  Google Scholar 

  34. 34. Wilson CM. Plasmodium Species (Malaria). In: Long SS, Pickering LK, Prober CG, eds. Principles and Practice of Pediatric Infectious Diseases. 2nd ed. New York, NY: Churchill Livingstone; 2003; 1295–1301.

    Google Scholar 

  35. Mehta PN. Malaria. eMedicine [serial online]. February 2006.

    Google Scholar 

  36. 36. Viani RM, Bromberg K. Pediatric imported malaria in New York: delayed diagnosis. Clin Pediatr (Phila). 1999; 38:333–337.

    CAS  Google Scholar 

  37. 37. Winters RA, Murray HW. Malaria—the mime revisited: fifteen more years of experience at a New York City teaching hospital. Am J Med. 1992; 93:243–246.

    PubMed  CAS  Google Scholar 

  38. 38. WHO. Management of Severe Malaria: A practical handbook. 2nd ed. Geneva, Switzerland: World Health Organization; 2000.

    Google Scholar 

  39. 39. Hulbert TV. Congenital malaria in the United States. Report of a case and review. Clin Infect Dis. 1992; 14:922–926.

    PubMed  CAS  Google Scholar 

  40. 40. Sowunmi A. Clinical study of cerebral malaria in African children. Afr J Med Sci. 1997; 26:9–11.

    CAS  Google Scholar 

  41. 41. Olumese PE, Gbadegesin RA, Adeyemo AA, Brown B, Walker A. Neurological features of cerebral malaria in Nigerian children. Ann Trop Pediatr. 1999; 19:321–325.

    CAS  Google Scholar 

  42. 42. John CC, Idro RI. Cerebral malaria in children. Infect Med. 2003; 20:53–58.

    Google Scholar 

  43. 43. Newton CR, Crawley J, Sowumni A, et al. Intracranial hypertension in Africans with cerebral malaria. Arch Dis Child. 1997; 76:219–226.

    PubMed  CAS  Google Scholar 

  44. 44. Brewster DR, Kwiatkowski D, White NJ. Neurological sequelae of cerebral malaria in children. Lancet. 1990; 336:1039–1043.

    PubMed  CAS  Google Scholar 

  45. 45. van Hensbroek MB, Palmer A, Jaffar S, Schneider G, Kwiatkowski D. Residual neurologic sequelae after childhood cerebral malaria. J Pediatr. 1997; 131:125–129.

    PubMed  Google Scholar 

  46. 46. Nguyen TH, Day NP, Ly VC, et al. Post-malaria neurological syndrome. Lancet. 1996; 348:917–921.

    PubMed  CAS  Google Scholar 

  47. 47. Senanayake N, de Silva HJ. Delayed cerebellar ataxia complicating falciparum malaria: a clinical study of 74 patients. J Neurol. 1994; 241:456–459.

    PubMed  CAS  Google Scholar 

  48. 48. White NJ. Neurological dysfunction following malaria: disease- or drug-related? Clin Inf Dis. 2000; 30:836.

    Google Scholar 

  49. 49. Elias Z, Bonnet E, Marchou B, Massip P. Neurotoxicity of artemisinin: possible counseling and treatment of side effects. Clin Infect Dis. 1999; 28:1330–1331.

    PubMed  CAS  Google Scholar 

  50. 50. Lowichik A, Ruff AJ. Parasitic infections of the central nervous system in children. Part II: Disseminated infections. J Child Neurol. 1995; 10:77–87.

    PubMed  CAS  Google Scholar 

  51. 51. Marsh K, Forster D, Waruiru C, et al. Indicators of life-threatening malaria in African children. N Engl J Med. 1995; 332:1399–1404.

    PubMed  CAS  Google Scholar 

  52. 52. Fairhurst RM, Wellems TE. Plasmodium species (Malaria). In: Mandell GL, Bennett JE, Dolin R, eds. Principles and Practice of Infectious Diseases. 6th ed. Philadelphia, PA: Churchill Livingstone; 2005; 3121–3144.

    Google Scholar 

  53. 53. McAdam AJ, Sharpe AH. Infectious Diseases. In: Kumar V, Abbas AK, Fausto N, eds. Robbins & Cotran: Pathologic Basis of Disease. 7th ed. Philadelphia, PA: Elsevier Saunders; 2005; 343–414.

    Google Scholar 

  54. 54. Crawley J, Smith S, Muthinji P, Marsh K, Kirkham F. Electroencephalographic and clinical features of cerebral malaria. Arch Dis Child. 2001; 84:247–253.

    PubMed  CAS  Google Scholar 

  55. 55. Newton CR, Peshu N, Kendall B, et al. Brain swelling and ischaemia in Kenyans with cerebral malaria. Arch Dis Child. 1994; 70:281–287.

    PubMed  CAS  Google Scholar 

  56. 56. Looareesuwan S, Wilairatana P, Krishna S, et al. Magnetic resonance imaging of the brain in patients with cerebral malaria. Clin Infect Dis. 1995; 21:300–309.

    PubMed  CAS  Google Scholar 

  57. 57. Karunajeewa HA, Kemiki A, Alpers MP, et al. Safety and therapeutic efficacy of artesunate suppositories for treatment of malaria in children in Papua New Guinea. Pediatr Infect Dis J. 2003; 22:251–255.

    PubMed  Google Scholar 

  58. 58. McIntosh HM, Olliaro P. Artemisinin derivatives for treating severe malaria. Cochrane Database Syst Rev. 2000; 2:CD000527.

    PubMed  Google Scholar 

  59. WHO. Facts on ACTS (Artemisinin-based Combination Therapies). January 2006 Update, World Health Organization, Geneva.

    Google Scholar 

  60. 60. American Academy of Pediatrics. Drugs for Parasitic Infections. In: Pickering LK, Baker CJ, Long SS, McMillan JA, eds. Red Book: 2006 Report of the Committee on Infectious Diseases. 27th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2006; 790–817.

    Google Scholar 

  61. 61. White NJ. The treatment of malaria. N Engl J Med. 1996; 335:800–806.

    PubMed  CAS  Google Scholar 

  62. 62. Crawley J, Waruiru C, Mithwani S, et al. Effect of phenobarbital on seizure frequency and mortality in childhood cerebral malaria: a randomised, controlled intervention. Lancet. 2000; 355:701–706.

    PubMed  CAS  Google Scholar 

  63. 63. Meremikwu M, Marson AG. Routine anticonvulsants for treating cerebral malaria. Cochrane Database Syst Rev. 2006; 2:CD002152.

    Google Scholar 

  64. 64. Yost J. Amebiasis. Pediatr Rev. 2002; 23:293–294.

    PubMed  Google Scholar 

  65. Horga MA, Naparst TR, Dhawan VK. Amebiasis. eMedicine [serial online]. March 2006.

    Google Scholar 

  66. 66. Hotez PJ, Strickland AD. Amebiasis. In: Feigin RD, Cherry JD, eds. Textbook of Pediatric Infectious Diseases. 5th ed. Philadelphia , PA: WB Saunders; 2004; 2660–2668.

    Google Scholar 

  67. 67. Hughes FB, Faehnle ST, Simon JL. Multiple cerebral abscesses complicating hepatopulmonary amebiasis. J Pediatr. 1979; 86:95–96.

    Google Scholar 

  68. 68. Lowichik A, Ruff AJ. Parasitic infections of the central nervous system in children. Part III: space-occupying lesions. J Child Neurol. 1995; 10:177–190.

    PubMed  CAS  Google Scholar 

  69. 69. Shah AA, Shaikh H, Karim M. Amoebic brain abscess: a rare but serious complication of Entamoeba histolytica infection. J Neurol Neurosurg Psychiatry. 1994; 57:240–241.

    PubMed  CAS  Google Scholar 

  70. 70. Schmutzhard E, Mayr U, Rumpl E, Prugger M, Pohl P. Secondary cerebral amebiasis due to infection with Entamoeba histolytica. A case report with computer tomographic findings. Eur Neurol. 1986; 25:161–165.

    PubMed  CAS  Google Scholar 

  71. 71. Becker GL, Knep S, Lance KP, Kaufman L. Amebic abscess of the brain. Neurosurgery. 1980; 6:192–194.

    PubMed  Google Scholar 

  72. 72. Kchouk M, Ghedas K, Bouhaouala MH, et al. [Amebic brain abscess. Apropos of a case.] Ann Radiol (Paris). 1993; 36:332–335.

    CAS  Google Scholar 

  73. 73. American Academy of Pediatrics. Amebiasis. In: Pickering LK, Baker CJ, Long SS, McMillan JA, eds. Red Book: 2006 Report of the Committee on Infectious Diseases. 27th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2006; 204–206.

    Google Scholar 

  74. 74. Dietz R, Schanen G, Kramann B, Erpelding J. Intracranial amebic abscesses: CT and MR findings. J Comput Assist Tomogr. 1991; 15:168–170.

    PubMed  CAS  Google Scholar 

  75. 75. van Sonnenberg E, Mueller PR, Schiffman HR, et al. Intrahepatic amebic abscess: indications for and results of percutaneous catheter drainage. Radiology. 1985; 156:631–635.

    Google Scholar 

  76. 76. Ohnishi K, Murata M, Kojima H, Takemura N, Tsuchida T, Tachibana H. Brain abscess due to infection with Entamoeba histolytica. Am J Trop Med Hyg. 1994; 51:180–182.

    PubMed  CAS  Google Scholar 

  77. 77. Fowler M, Carter RF. Acute pyogenic meningitis probably due to Acanthamoeba sp: a preliminary report. Br Med J. 1965; 2:740–742.

    PubMed  CAS  Google Scholar 

  78. 78. Barnett ND, Kaplan AM, Hopkin RJ, Saubolle MA, Rudinsky MF. Primary amoebic meningoencephalitis with Naegleria fowleri: clinical review. Pediatr Neurol. 1996; 15:230–234.

    PubMed  CAS  Google Scholar 

  79. 79. Bottone EJ. Free-living amebas of the genera Acanthamoeba and Naegleria: an overview and basic microbiology correlates. Mt Sinai J Med. 1993; 60:260–270.

    PubMed  CAS  Google Scholar 

  80. 80. Martinez AJ. Free-living amebas: infection of the central nervous system. Mt Sinai J Med. 1993; 60:271–278.

    PubMed  CAS  Google Scholar 

  81. 81. Denney CF, Iragui VJ, Uber-Zak LD, et al. Amebic meningoencephalitis by Balamuthia mandrillaris: case report and review. Clin Infect Dis. 1997; 25:1354–1358.

    PubMed  CAS  Google Scholar 

  82. 82. Griesemer DA, Barton LL, Reese CM, et al. Amebic meningoencephalitis caused by Balamuthia mandrillaris. Pediatr Neurol. 1994; 10:249–254.

    PubMed  CAS  Google Scholar 

  83. 83. Deetz TR, Sawyer MH, Billman G, et al. Successful treatment of Balamuthia amoebic encephalitis: presentation of 2 cases. Clin Infect Dis. 2003; 37:1304–1312.

    PubMed  Google Scholar 

  84. 84. Seidel JS. Naegleria, Acanthamoeba, and Balamuthia. In: Feigin RD, Cherry JD, eds. Textbook of Pediatric Infectious Diseases. 5th ed. Philadelphia, PA: WB Saunders; 2004; 2748–2755.

    Google Scholar 

  85. 85. American Academy of Pediatrics. Amebic meningoencephalitis and keratitis. In: Pickering LK, Baker CJ, Long SS, McMillan JA, eds. Red Book: 2006 Report of the Committee on Infectious Diseases. 27th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2006; 206–208.

    Google Scholar 

  86. 86. Asbell PA. Acanthamoeba keratitis: there and back again. Mt Sinai Med J., 1993; 60:279–282.

    CAS  Google Scholar 

  87. 87. Schuster FL, Honarmand S, Visvesvara GS, Glaser CA. Detection of antibodies against free-living amoebae Balamuthia mandrillaris and Acanthamoeba species in a population of patients with encephalitis. Clin Infect Dis. 2006; 42:1260–1265.

    PubMed  CAS  Google Scholar 

  88. 88. Martinez AJ, Visvesvara GS. Balamuthia mandrillaris infection. J Med Microbiol. 2001; 50:205–207.

    PubMed  CAS  Google Scholar 

  89. 89. Schumacher DJ, Tien RD, Lane K. Neuroimaging findings in rare amebic infections of the central nervous system. Am J Neuroradiol. 1995; 16:930–935.

    PubMed  CAS  Google Scholar 

  90. 90. Kidney DD, Kim SH. CNS infections with free-living amebas: neuroimaging findings. Am J Roentgenol. 1998; 171:809–812.

    CAS  Google Scholar 

  91. 91. Schuster FL. Cultivation of pathogenic and opportunistic free-living amebas. Clin Microbiol Rev. 2002; 15:342–354.

    PubMed  Google Scholar 

  92. 92. Schuster FL, Visvesvara GS. Axenic growth and sensitivity studies of Balamuthia mandrillaris, an agent of amebic meningoencephalitis in humans and other animals. J Clin Microbiol. 1996; 34:385–388.

    PubMed  CAS  Google Scholar 

  93. 93. Sparagano O, Drouet E, Denoyel G, Pernin P, Ruchard-Sparagano MH. Differentiation of Naegleria fowleri from other species of Naegleria using monoclonal antibodies and the polymerase chain reaction. Trans R Soc Trop Med Hyg. 1994; 88:119–120.

    PubMed  CAS  Google Scholar 

  94. 94. Reveiller FL, Cabanes PA, Marciano-Cabral F. Development of a nested PCR assay to detect the pathogenic free-living amoeba Naegleria fowleri. Parasitol Res. 2002; 88:443–450.

    PubMed  Google Scholar 

  95. 95. Lai S, Asgari M, Henney HR. Non-radioactive DNA probe and polymerase chain reaction procedures for the specific detection of Acanthamoeba. Mol Cell Probes. 1994; 8:81–89.

    PubMed  CAS  Google Scholar 

  96. 96. Healy JF. Balamuthia amebic encephalitis: radiographic and pathologic findings. Am J Neuroradiol. 2002; 23:486–489.

    PubMed  Google Scholar 

  97. 97. Goswick SM, Brenner GM. Activities of azithromycin and amphotericin B against Naegleria fowleri in vitro and in a mouse model of primary amebic meningoencephalitis. Antimicrob Agents Chemother. 2003; 47:524–528.

    PubMed  CAS  Google Scholar 

  98. 98. Singhal T, Bajpai A, Kalra V, et al. Successful treatment of Acanthamoeba meningitis with combination oral antimicrobials. Pediatr Infect Dis J. 2001; 20:623–627.

    PubMed  CAS  Google Scholar 

  99. 99. Ortega-Barria E. Trypanosoma species. In: Long SS, Pickering LK, Prober CG, eds. Principles and Practice of Pediatric Infectious Diseases. 2nd ed. New York, NY: Churchill Livingston; 2003; 1324–1330.

    Google Scholar 

  100. Kiminyo KK, Lucey DR. African Trypanosomiasis (Sleeping Sickness). eMedicine Journal 2002.

    Google Scholar 

  101. 101. Wittner M, Tanowitz HB. Trypanosomiasis. In: Feigin RD, Cherry JD, eds. Textbook of Pediatric Infectious Diseases. 5th ed. Philadelphia, PA: WB Saunders; 2004; 2739–2748.

    Google Scholar 

  102. 102. Truc P, Lejon V, Magnus E, et al. Evaluation of the micro-CATT, CATT/Trypanosoma brucei gambiense, and LATEX/T.b. gambiense methods for serodiagnosis and surveillance of human African trypanosomiasis in West and Central Africa. Bull World Health Organ. 2002; 80:882–886.

    PubMed  Google Scholar 

  103. 103. Jamonneau V, Solano P, Garcia A, et al. Stage determination and therapeutic decision in human African trypanosomiasis: value of polymerase chain reaction and immunoglobulin M quantification on the cerebrospinal fluid of sleeping sickness patients in Cote d’ Ivoire. Trop Med Int Health. 2003; 8:589–594.

    PubMed  CAS  Google Scholar 

  104. 104. Gill DS, Chatha DS, del Carpio-O'Donovan R. MR imaging findings in African trypanosomiasis. Am J Neuroradiol. 2003; 24:1383–1385.

    PubMed  Google Scholar 

  105. 105. Legros D, Ollivier G, Gastellu-Etchegorry M, et al. Treatment of human African trypanosomiasis: present situation and needs for research and development. Lancet Infect Dis. 2002; 2:437–440.

    PubMed  Google Scholar 

  106. 106. Burri C, Nkunku S, Merolle A, Smith T, Blum J, Brun R. Efficacy of new, concise schedule for melarsoprol in treatment of sleeping sickness caused by Trypanosoma brucei gambiense: a randomised trial. Lancet. 2000; 355:1419–1425.

    PubMed  CAS  Google Scholar 

  107. 107. Burri C, Brun R. Eflornithine for the treatment of human African trypanosomiasis. Parasitol Res. 2003; 90:S49–52.

    PubMed  Google Scholar 

  108. 108. Pepin J, Milord F, Guern C, Mpia B, Ethier L, Mansinsa D. Trial of prednisolone for prevention of melarsoprol-induced encephalopathy in gambiense sleeping sickness. Lancet. 1989; 1:1246–1250.

    PubMed  CAS  Google Scholar 

  109. 109. Prata A. Clinical and epidemiological aspects of Chagas disease. Lancet Infect Dis. 2001; 1:92–100.

    PubMed  CAS  Google Scholar 

  110. Centers for Disease Control and Prevention (CDC). Chagas disease after organ transplantation—Los Angeles, California, 2006. MMWR. 2006; 55:798–800.

    Google Scholar 

  111. Centers for Disease Control and Prevention (CDC). Chagas disease after organ transplantation—United States, 2001. MMWR. 2002; 51:210–212.

    Google Scholar 

  112. 112. Freilij H, Altcheh J. Congenital Chagas disease: diagnostic and clinical aspects. Clin Infect Dis. 1995; 21:551–555.

    PubMed  CAS  Google Scholar 

  113. 113. Del Castillo M, Mendoza G, Oviedo J, Perez Bianco RP, Anselmo AE, Silva M. AIDS and Chagas disease with central nervous system tumor-like lesion. Am J Med. 1990; 88:693–694.

    PubMed  Google Scholar 

  114. 114. Ferreira MS, Nishioka Sde A, Silvestre MT, Borges AS, Nunes-Araujo FR, Rocha A. Reactivation of Chagas’ disease in patients with AIDS: report of three new cases and review of the literature. Clin Infect Dis. 1997; 25:1397–1400.

    PubMed  CAS  Google Scholar 

  115. 115. Di Lorenzo GA, Pagano MA, Taratuto AL, Garau ML, Meli FJ, Pomsztein, MD. Chagasic granulomatous encephalitis in immunosuppressed patients. Computed tomography and magnetic resonance imaging findings. J Neuroimaging. 1996; 6:94–97.

    PubMed  CAS  Google Scholar 

  116. 116. Goldani LZ. A 32-year-old Brazilian woman with severe headache and fever. Clin Infect Dis. 2002; 35:1549–1550.

    Google Scholar 

  117. 117. Walker M, Zunt JR. Parasitic central nervous system infections in immunocompromised hosts. Clin Infect Dis. 2005; 40:1005–1015.

    PubMed  Google Scholar 

  118. 118. Silva AA, Roffe E, Marino AP, et al. Chagas’ disease encephalitis: intense CD8+ lymphocytic infiltrate is restricted to the acute phase, but is not related to the presence of Trypanosoma cruzi antigens. Clin Immunol. 1999; 92:56–66.

    PubMed  CAS  Google Scholar 

  119. 119. Wincker P, Telleria J, Bosseno MF, et al. PCR-based diagnosis for Chagas’ disease in Bolivian children living in an active transmission area: comparison with conventional serological and parasitological diagnosis. Parasitology. 1997; 114:367–373.

    PubMed  Google Scholar 

  120. 120. Villar JC, Marin-Neto JA, Ebrahim S, Yusuf S. Trypanocidal drugs for chronic asymptomatic Trypanosoma cruzi infection. Cochrane Database Syst Rev. 2002; 1:CD003463.

    PubMed  Google Scholar 

  121. 121. Reyes PA, Vallejo M. Trypanocidal drugs for late stage, symptomatic Chagas disease (Trypanosoma cruzi infection). Cochrane Database Syst Rev. 2005; 4:CD004102.

    PubMed  Google Scholar 

  122. 122. Solari A, Ortiz S, Soto A, et al. Treatment of Trypanosoma cruzi-infected children with nifurtimox: a 3 year follow-up by PCR. J Antimicrob Chemother. 2001; 48:515–519.

    PubMed  CAS  Google Scholar 

  123. 123. Galvao LM, Chiari E, Macedo AM, Laguetti AO, Silva SA, Andrade AL. PCR assay for monitoring Trypanosoma cruzi parasitemia in childhood after specific chemotherapy. J Clin Microbiol. 2003; 41:5066–5070.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. University of Florida College of Medicine, Jacksonville, FL, USA

    Ana M. Alvarez M.D. (Assistant Professor of Pediatrics)

  2. University of Florida College of Medicine and Wolfson Children's Hospital, Director Rainbow Center for Women, Adolescents, Children and Families, Jacksonville, FL, USA

    Mobeen H. Rathore M.D., C.P.E., F.A.A.P. (Professor of Pediatrics and Associate Chairman, Chief Division of Pediatric Infectious Diseases and Immunology)

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  1. Ana M. Alvarez M.D.
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  2. Mobeen H. Rathore M.D., C.P.E., F.A.A.P.
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© 2008 Humana Press, a part of Springer Science + Business Media, LLC

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Alvarez, A.M., Rathore, M.H. (2008). Protozoal Infections. In: The Neurological Manifestations of Pediatric Infectious Diseases and Immunodeficiency Syndromes. Infectious Disease™. Humana Press. https://doi.org/10.1007/978-1-59745-391-2_35

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  • DOI: https://doi.org/10.1007/978-1-59745-391-2_35

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-967-3

  • Online ISBN: 978-1-59745-391-2

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