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The Aging of the Retina

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Visual Transduction and Non-Visual Light Perception

Part of the book series: Ophthalmology Research ((OPHRES))

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References

  1. Harman, D. (1981) The aging process. Proc. Natl. Acad. Sci. U. S. A. 24, 7124–7128.

    Article  Google Scholar 

  2. Curcio, C.A., Sloan, K.R., Kalina, R.E., Hendrickson, A.E. (1990) Human photoreceptor topography. J. Comp. Neurol. 292, 497–523.

    Article  PubMed  CAS  Google Scholar 

  3. Marshall, J. (1987) The ageing retina: physiology or pathology. Eye. 1, 282–95.

    PubMed  Google Scholar 

  4. Curcio, C.A., Presley, J.B., Millican, C.L., Medeiros N.E. (2005) Basal deposits and drusen in eyes with age-related maculopathy: evidence for solid lipid particles. Exp. Eye. Res. 80, 761–775.

    Article  PubMed  CAS  Google Scholar 

  5. Curcio, C.A., Millican, C.L., Allen, K.A., Kalina, R.E. (1993) Aging of the human photore-ceptor mosaic: evidence for selective vulnerability of rods in central retina. Invest. Ophthal-mol. Vis. Sci. 34, 3278–3296.

    CAS  Google Scholar 

  6. Gao, H., Hollyfield, J.G. (1992) Aging of the human retina. Differential loss of neurons and retinal pigment epithelial cells. Invest. Ophthalmol. Vis. Sci. 33, 1–17.

    PubMed  CAS  Google Scholar 

  7. Clarke, G., Collins, R.A., Leavitt, B.R., Rews, D.F., Hayden, M.R., Lumsden, C.J., McInnes, R.R. (2000) A one-hit model of cell death in inherited neuronal degenerations. Nature. 406, 195–199.

    Article  PubMed  CAS  Google Scholar 

  8. Cideciyan, A.V., Hood, D.C., Huang, Y., Banin, E., Li, Z.Y., Stone, E.M., Milam, A.H., Jacobson S.G. (1998) Disease sequence from mutant rhodopsin allele to rod and cone pho-toreceptor degeneration in man. Proc. Natl. Acad. Sci. U. S. A. 95, 7103–718.

    Article  PubMed  CAS  Google Scholar 

  9. Hicks, D., Sahel, J. (1999) The implications of rod-dependent cone survival for basic and clinical research. Invest. Ophthalmol. Vis. Sci. 40, 3071–3074.

    PubMed  CAS  Google Scholar 

  10. Petters, R.M., Alexander, C.A., Wells, K.D., Collins, E.B., Sommer J.R., Blanton, M.R., Rojas, G., Hao, Y., Flowers, W.L., Banin, E., Cideciyan, A.V., Jacobson, S.G., Wong, F. (1997) Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in retinitis pigmentosa. Nat. Biotechnol. 15, 965–970.

    Article  PubMed  CAS  Google Scholar 

  11. Leveillard, T., Mohand-Said, S., Lorentz, O., Hicks, D., Fintz, A.C., Clerin, E., Simonutti, M., Forster, V., Cavusoglu, N., Chalmel, F., Dolle, P., Poch, O., Lambrou, G., Sahel, J.A. (2004) Identification and characterization of rod-derived cone viability factor. Nat. Genet. 36, 755–759.

    Article  PubMed  CAS  Google Scholar 

  12. Mohand-Said, S., Hicks, D., Dreyfus, H., Sahel, J.A. (2000) Selective transplantation of rods delays cone loss in a retinitis pigmentosa model. Arch. Ophthalmol. 118, 807–811.

    PubMed  CAS  Google Scholar 

  13. Mohand-Said, S., Hicks, D., Leveillard, T., Picaud, S., Porto, F., Sahel, J.A. (2001) Rod-cone interactions: developmental and clinical significance. Prog. Retin. Eye. Res. 20, 451–467.

    Article  PubMed  CAS  Google Scholar 

  14. Fintz, A.C., Audo, I., Hicks, D., Mohand-Said, S., Leveillard, T, and Sahel, J. (2003) Partial characterization of retina-derived cone neuroprotection in two culture models of photorecep-tor degeneration. Invest. Ophthalmol. Vis. Sci. 44, 818–825.

    Article  PubMed  Google Scholar 

  15. Curcio, C.A., Owsley, C., Jackson, G.R. (2000) Spare the rods, save the cones in aging and age-related maculopathy. Invest. Ophthalmol. Vis. Sci. 41, 2015–2018.

    PubMed  CAS  Google Scholar 

  16. Barron, M.J., Johnson, M.A., Rews, R.M., Clarke, M.P., Griffiths P.G., Bristow, E., He, L.P., Durham, S., Turnbull, D.M. (2001) Mitochondrial abnormalities in ageing macular photore-ceptors. Invest. Ophthalmol. Vis. Sci. 42, 3016–3022.

    PubMed  CAS  Google Scholar 

  17. Winkler, B.S., Boulton, M.E., Gottsch, J.D., Sternberg, P. (1999) Oxidative damage and age-related macular degeneration. Mol. Vis. 5, 32.

    PubMed  CAS  Google Scholar 

  18. Ramirez, J.M., Ramirez, A.I., Salazar, J.J., de Hoz, R., Trivino, A. (2001) Changes of astro-cytes in retinal ageing and age-related macular degeneration. Exp. Eye. Res. 73, 601–615.

    Article  PubMed  CAS  Google Scholar 

  19. Curcio, C.A., Drucker, D.N. (1993) Retinal ganglion cells in Alzheimer's disease and aging. Ann. Neurol. 33, 248–257.

    Article  PubMed  CAS  Google Scholar 

  20. Szweda, P.A., Camouse, M., Lundberg, K.C., Oberley, T.D., Szweda, L.I. (2003) Aging, lipofuscin formation, and free radical-mediated inhibition of cellular proteolytic systems. Ageing Res. Rev. 2, 383–405.

    Article  PubMed  CAS  Google Scholar 

  21. Schutt, F., Davies, S., Kopitz, J., Holz, F.G., Boulton, M.E. (2000) Photodamage to human RPE cells by A2-E, a retinoid component of lipofuscin. Invest. Ophthalmol. Vis. Sci. 41, 2303–2308.

    PubMed  CAS  Google Scholar 

  22. Young, R.W., Bok, D. (1969) Participation of the retinal pigment epithelium in the rod outer segment renewal process. J. Cell. Biol. 42, 392–403.

    Article  PubMed  CAS  Google Scholar 

  23. Katz, M.L. (2002) Potential role of retinal pigment epithelial lipofuscin accumulation in age-related macular degeneration. Arch. Gerontol. Geriatr. 34, 359–370.

    Article  PubMed  CAS  Google Scholar 

  24. Holz, F.G., Schutt, F., Kopitz, J., Eldred, G.E., Kruse, F.E., Volcker, H.E., Cantz, M. (1999) Inhibition of lysosomal degradative functions in RPE cells by a retinoid component of lipo-fuscin. Invest. Ophthalmol. Vis. Sci. 40, 737–743.

    CAS  Google Scholar 

  25. Bergmann, M., Schutt, F., Holz, F.G., Kopitz, J. (2004) Inhibition of the ATP-driven proton pump in RPE lysosomes by the major lipofuscin fluorophore A2-E may contribute to the pathogenesis of age-related macular degeneration. FASEB J. 18, 562–564.

    PubMed  CAS  Google Scholar 

  26. Sparrow, J.R., Nakanishi, K., Parish, C.A. (2000) The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells. Invest. Ophthalmol. Vis. Sci. 41, 1981–1989.

    PubMed  CAS  Google Scholar 

  27. Suter, M., Reme, C., Grimm, C., Wenzel, A., Jaattela, M., Esser, P., Kociok, N., Leist, M., Richter, C. (2000) Age-related macular degeneration. The lipofusion component N-retinyl-N-retinylidene ethanolamine detaches proapoptotic proteins from mitochondria and induces apoptosis in mammalian retinal pigment epithelial cells. J. Biol. Chem. 275, 39625–39630.

    Article  PubMed  CAS  Google Scholar 

  28. Boulton, M., Dontsov, A., Jarvis-Evans, J., Ostrovsky, M., Svistunenko, D. (1993) Lipofus-cin is a photoinducible free radical generator. J. Photochem. Photobiol. B. 19, 201–204.

    Article  PubMed  CAS  Google Scholar 

  29. Schutt, F., Bergmann, M., Holz, F.G., Kopitz, J. (2003) Proteins modified by malondialde-hyde, 4-hydroxynonenal, or advanced glycation end products in lipofuscin of human retinal pigment epithelium. Invest. Ophthalmol. Vis. Sci. 44, 3663–3668.

    Article  PubMed  Google Scholar 

  30. Eldred, G.E., Lasky, M.R. (1993) Retinal age pigments generated by self assembling lyso-somotropic detergents. Nature. 361, 724–726.

    Article  PubMed  CAS  Google Scholar 

  31. Roth, F., Bindewald, A., Holz, F.G. (2004) Key pathophysiologic pathways in age-related macular disease. Graefes. Arch. Clin. Exp. Ophthalmol. 242, 710–716.

    Article  PubMed  Google Scholar 

  32. Kopitz, J., Holz, F.G., Kaemmerer, E., Schutt, F. (2004) Lipids and lipid peroxidation products in the pathogenesis of age-related macular degeneration. Biochimie. 86, 825–831.

    Article  PubMed  CAS  Google Scholar 

  33. Fishkin, N., Sparrow, J.R., Allikmets, R., Nakanishi, K. (2005) Isolation and characterization of a retinal pigment epithelial cell fluorophore: an all-trans-retinal dimer conjugate. Proc. Natl. Acad. Sci. U. S. A. 102, 7091–7096.

    Article  PubMed  CAS  Google Scholar 

  34. Hogan, M.J., Alvarado, J. (1967) Studies on the human macula. IV. Aging changes in Bruch's membrane. Arch. Ophthalmol. 77, 410–420.

    PubMed  CAS  Google Scholar 

  35. Guymer, R., Luthert, P., Bird, A. &$$$;(1999 Changes in Bruch's membrane and related structures with age. Prog. Retin. Eye. Res. 18, 59–90.

    Article  PubMed  CAS  Google Scholar 

  36. Grindle, C.F., Marshall, J. (1978) Ageing changes in Bruch's membrane and their functional implications. Trans. Ophthalmol. Soc. U. K. 98, 172–175.

    PubMed  CAS  Google Scholar 

  37. Chong, N.H., Keonin, J., Luthert, P.J., Frennesson, C.I., Weingeist, D.M., Wolf, R.L., Mullins, R.F., Hageman, G.S. (2005) Decreased thickness and integrity of the macular elastic layer of Bruch's membrane correspond to the distribution of lesions associated with age-related macular degeneration. Am. J. Pathol. 166, 241–251.

    Article  PubMed  Google Scholar 

  38. Anderson, D.H., Mullins, R.F., Hageman, G.S., Johnson, L.V. (2002) A role for local inflammation in the formation of drusen in the aging eye. Am. J. Ophthalmol. 134, 411–431.

    Article  PubMed  CAS  Google Scholar 

  39. Johnson, L.V., Leitner, W.P., Rivest, A.J., Staples, M.K., Radeke, M.J., Anderson, D.H. (2002) The Alzheimer's A beta-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration. Proc. Natl. Acad. Sci. U. S. A. 99, 11830–11835.

    Article  PubMed  CAS  Google Scholar 

  40. Mullins, R.F., Russell, S.R., Erson, D.H., Hageman, G.S. (2000) Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. FASEB J. 14, 835–846.

    PubMed  CAS  Google Scholar 

  41. Anderson, D.H., Talaga, K.C., Rivest, A.J., Barron, E., Hageman, G.S., Johnson, L.V. (2004) Characterization of beta amyloid assemblies in drusen: the deposits associated with aging and age-related macular degeneration. Exp. Eye. Res. 78, 243–256.

    Article  PubMed  CAS  Google Scholar 

  42. Farboud, B., Aotaki-Keen, A., Miyata, T., Hjelmeland, L.M., Handa, J.T. (1999) Development of a polyclonal antibody with broad epitope specificity for advanced glycation endproducts and localization of these epitopes in Bruch's membrane of the aging eye. Mol. Vis. 5, 11.

    PubMed  CAS  Google Scholar 

  43. Ishibashi, T., Murata, T., Hangai, M., Nagai, R., Horiuchi, S., Lopez, P.F., Hinton, D.R., Ryan, S.J. (1998) Advanced glycation end products in age-related macular degeneration. Arch. Ophthalmol. 116:1629–1632.

    PubMed  CAS  Google Scholar 

  44. Curcio, C.A., Millican, C.L., Bailey, T., Kruth, H.S. (2001) Accumulation of cholesterol with age in human Bruch's membrane. Invest. Ophthalmol. Vis. Sci. 42, 265–274.

    PubMed  CAS  Google Scholar 

  45. Lamb, T.D., Pugh, E.N. Jr. (2004) Dark adaptation and retinoid cycle of vision. Prog. Retin. Eye. Res. 23, 307–380.

    Article  PubMed  CAS  Google Scholar 

  46. Lovie-Kitchin, J.E., Brown, B. (2000) Repeatability and intercorrelations of standard vision tests as a function of age. Optom. Vis. Sci. 77, 412–420.

    Article  PubMed  CAS  Google Scholar 

  47. Rubin, G.S., West, S.K., Munoz, B., Bandeen-Roche, K., Zeger, S., Schein, O., Fried, L.P. (1997) A comprehensive assessment of visual impairment in a population of older Americans. The SEE Study. Salisbury Eye Evaluation Project. Invest. Ophthalmol. Vis. Sci. 38, 557–568.

    PubMed  CAS  Google Scholar 

  48. Schneck, M.E., Haegerstrom-Portnoy, G., Lott, L.A., Brabyn, J.A., Gildengorin, G. (2004) Low contrast vision function predicts subsequent acuity loss in an aged population: the SKI study. Vision Res. 44, 2317–2325.

    Article  PubMed  Google Scholar 

  49. Haegerstrom-Portnoy, G., Schneck, M.E., Brabyn, J.A. (1999) Seeing into old age: vision function beyond acuity. Optom. Vis. Sci. 76, 141–158.

    Article  PubMed  CAS  Google Scholar 

  50. Guirao, A., Gonzalez, C., Redondo, M., Geraghty, E., Norrby, S., Artal, P. (1999) Average optical performance of the human eye as a function of age in a normal population. Invest. Ophthalmol. Vis. Sci. 40, 203–213.

    PubMed  CAS  Google Scholar 

  51. Johnson, C.A., Adams, A.J., Lewis, R.A. (1989) Evidence for a neural basis of age-related visual field loss in normal observers. Invest. Ophthalmol. Vis. Sci. 30, 2056–2064.

    PubMed  CAS  Google Scholar 

  52. Johnson, C.A., Marshall, D., Jr. (1995) Aging effects for opponent mechanisms in the central visual field. Optom. Vis. Sci. 72, 75–82.

    Article  PubMed  CAS  Google Scholar 

  53. Jackson, G.R., Owsley, C. (2000) Scotopic sensitivity during adulthood. Vision Res. 40, 2467–2473.

    Article  PubMed  CAS  Google Scholar 

  54. Jackson, G.R., Owsley, C., McGwin, G., Jr. (1999) Aging and dark adaptation. Vision Res. 39, 3975–3982.

    Article  PubMed  CAS  Google Scholar 

  55. Owsley, C., Jackson, G.R., White, M., Feist, R., Edwards, D. (2001) Delays in rod-mediated dark adaptation in early age-related maculopathy. Ophthalmology. 108, 1196–1202.

    Article  PubMed  CAS  Google Scholar 

  56. Pauleikhoff, D., Chen, J.C., Chisholm, I.H., Bird, A.C. (1990) Choroidal perfusion abnormality with age-related Bruch's membrane change. Am. J. Ophthalmol. 109, 211–217.

    PubMed  CAS  Google Scholar 

  57. Schefrin, B.E., Bieber, M.L., McLean, R., Werner, J.S. (1998) The area of complete sco-topic spatial summation enlarges with age. J. Opt. Soc. Am. A. Opt. Image. Sci. Vis. 15, 340–348.

    Article  PubMed  CAS  Google Scholar 

  58. Birch, D.G., Anderson, J.L. (1992) Standardized full-field electroretinography, normal values and their variation with age. Arch. Ophthalmol. 110, 1571–1576.

    PubMed  CAS  Google Scholar 

  59. Weleber, R.G. (1981) The effect of age on human cone and rod ganzfeld electroretinograms. Invest. Ophthalmol. Vis. Sci. 20, 392–399.

    PubMed  CAS  Google Scholar 

  60. Fortune, B., Johnson, C.A. (2002) Decline of photopic multifocal electroretinogram responses with age is due primarily to preretinal optical factors. J. Opt. Soc. Am. A. Opt. Image. Sci. Vis. 19, 173–184.

    Article  PubMed  Google Scholar 

  61. Gerth, C., Garcia, S.M., Ma, L., Keltner, J.L., Werner, J.S. (2002) Multifocal electroretino-gram: age-related changes for different luminance levels. Graefes. Arch. Clin. Exp. Ophthal-mol. 240, 202–208.

    Article  Google Scholar 

  62. Kurtenbach, A., Weiss, M. (2002) Effect of aging on multifocal oscillatory potentials. J. Opt. Soc. Am. A. Opt. Image. Sci. Vis. 19, 190–196.

    Article  PubMed  Google Scholar 

  63. Klein, R., Klein, B.E., Linton, K.L. (1992) Prevalence of age-related maculopathy. The Beaver Dam Eye Study. Ophthalmology. 99, 933–943.

    PubMed  CAS  Google Scholar 

  64. Bird, A.C., Bressler, N.M., Bressler, S.B., Chisholm, I.H., Coscas, G., Davis, M.D., de Jong, P.T., Klaver, C.C., Klein, B.E., Klein, R., Mitchell, P., Sarks, J.P., Sarks, S.H., Soubrane, G., Taylor, H.R., Vingerling, J.R. (1995) An international classification and grading system for age-related maculopathy and age-related macular degeneration. The International ARM Epi-demiological Study Group. Surv. Ophthalmol. 39, 367–374.

    Article  PubMed  CAS  Google Scholar 

  65. Whittaker, S.G., Budd, J., Cummings, R.W. (1988) Eccentric fixation with macular scotoma. Invest. Ophthalmol. Vis. Sci. 29, 268–278.

    PubMed  CAS  Google Scholar 

  66. Age-Related Eye Disease Study Research Group. (2001) A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch. Ophthalmol. 119, 1417–1436.

    Google Scholar 

  67. Evans, J.R. (2001) Risk factors for age-related macular degeneration. Prog. Retin. Eye. Res. 20, 227–53.

    Article  PubMed  CAS  Google Scholar 

  68. Grizzard, S.W., Arnett, D., Haag, S.L. (2003) Twin study of age-related macular degeneration. Ophthalmic Epidemiol. 10, 315–322.

    Article  PubMed  Google Scholar 

  69. Hammond, C.J., Webster, A.R., Snieder, H., Bird, A.C., Gilbert, C.E., Spector, T.D. (2002) Genetic influence on early age-related maculopathy: a twin study. Ophthalmology. 109, 730–736.

    Article  PubMed  Google Scholar 

  70. Sepp, T., Khan, J.C., Thurlby, D.A., Shahid, H., Clayton, D.G., Moore, A.T., Bird, A.C., Yates, J.R. (2006) Complement factor H variant Y402H is a major risk determinant for geographic atrophy and choroidal neovascularization in smokers and nonsmokers. Invest. Oph-thalmol. Vis. Sci. 47, 536–540.

    Article  Google Scholar 

  71. Malek, G., Johnson, L.V., Mace, B.E., Saloupis, P., Schmechel, D.E., Rickman, D.W., Toth, C.A., Sullivan, P.M., Bowes Rickman, C. (2005) Apolipoprotein E allele-dependent patho-genesis: a model for age-related retinal degeneration. Proc. Natl. Acad. Sci. U. S. A. 102, 11900–11905.

    Article  PubMed  CAS  Google Scholar 

  72. Rivera, A., White, K., Stohr, H., Steiner, K., Hemmrich, N., Grimm, T., Jurklies, B., Lorenz, B., Scholl, H.P., Apfelstedt-Sylla, E., Weber, B.H. (2000) A comprehensive survey of sequence variation in the ABCA4 (ABCR) gene in Stargardt disease and age-related macular degeneration. Am. J. Hum. Genet. 67, 800–813.

    Article  PubMed  CAS  Google Scholar 

  73. Radu, R.A., Mata, N.L., Nusinowitz, S., Liu, X., Sieving, P.A., Travis, G.H. (2003) Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Star-gardt's macular degeneration. Proc. Natl. Acad. Sci. U. S. A 100, 4742–7.

    Article  PubMed  CAS  Google Scholar 

  74. Radu, R.A., Han, Y., Bui, T.V., Nusinowitz, S., Bok, D., Lichter, J., Widder, K., Travis, G.H., Mata, N.L. (2005) Reductions in serum vitamin A arrest accumulation of toxic retinal fluorophores: a potential therapy for treatment of lipofuscin-based retinal diseases. Invest. Ophthalmol. Vis. Sci. 46, 4393–4401.

    Article  PubMed  Google Scholar 

  75. Maiti, P., Kong, J., Kim, S.R., Sparrow, J.R., Allikmets, R., Rando, R.R. (2006) Small molecule RPE65 antagonists limit the visual cycle and prevent lipofuscin formation. Biochemistry. 45, 852–860.

    Article  PubMed  CAS  Google Scholar 

  76. Liu, J., Itagaki, Y., Ben-Shabat, S., Nakanashi, K., Sparrow, J.R. (2000) The biosynthesis of A2E, a fluorophore of aging retina, involves the formation of the precursor, A2-PE, in the photoreceptor outer segment membrane. J. Biol. Chem. 275, 29354–29360.

    Article  PubMed  CAS  Google Scholar 

  77. Ben-Shabat, S., Parish, C.A., Vollmer, H.R., Itagaki, Y., Fishkin, N., Nakanishi, K., Sparrow, J.R. (2002) Biosynthetic studies of A2E, a major fluorophore of retinal pigment epithelial lipofuscin. J. Biol. Chem. 77, 7183–7190.

    Article  Google Scholar 

  78. Kim, S.R., Nakanishi, K., Itagaki, Y., Sparrow, J.R. (2006) Photooxidation of A2-PE, a photoreceptor outer segment fluorophore, and protection by lutein and zeaxanthin. Exp. Eye. Res. 82, 828–839.

    Article  PubMed  CAS  Google Scholar 

  79. Gragoudas, E.S., Adamis, A.P., Cunningham, E.T., Jr., Feinsod, M., Guyer, D.R. (2004) VEGF Inhibition Study in Ocular Neovascularization Clinical Trial Group. Pegaptanib for neovascular age-related macular degeneration. N. Engl. J. Med. 351, 2805–2816.

    Article  PubMed  CAS  Google Scholar 

  80. Heier, J.S., Antoszyk, A.N., Pavan, P.R., Leff, S.R., Rosenfeld, P.J., Ciulla, T.A., Dreyer, R.F., Gentile, R.C., Sy, J.P., Hantsbarger, G., Shams, N. (2006) Ranibizumab for treatment of neovascular age-related macular degeneration. A phase I/II multicenter, controlled, multi-dose study. Ophthalmology. 113, 642.e1–e4.

    Google Scholar 

  81. Bochow, T.W., D'Amico, D.J., Marks, B., Jerdan, J., Sullivan, E.K., Robertson, S.M., Slakter, J.S., Sullins, G., Zilliox, P., Anecortave Acetate Clinical Study Group. (2006) Anecortave acetate (15 milligrams) versus photodynamic therapy for treatment of subfoveal neovascu-larization in age-related macular degeneration. Ophthalmology. 113, 3–13.

    Article  PubMed  Google Scholar 

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  1. Centre Hospitalier National d'Ophtalmogie des Quinze-Vingts, and INSERM U 592, Paris, France

    Caren Bellmann & José A. Sahel

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  1. Department of Ophthalmology, Department of Neural and Behavioral Sciences, Milton S. Hershey Medical Center, Penn State University College of Medicine, Hershey, PA, USA

    Joyce Tombran-Tink Phd , Colin J. Barnstable DPhil , Joyce Tombran-Tink PhD  & Colin J. Barnstable DPhil , ,  & 

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Bellmann, C., Sahel, J.A. (2008). The Aging of the Retina. In: Tombran-Tink, J., Barnstable, C.J. (eds) Visual Transduction and Non-Visual Light Perception. Ophthalmology Research. Humana Press. https://doi.org/10.1007/978-1-59745-374-5_18

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