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References
Global Initiative for Chronic Obstructive Lung Disease (2006) Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease. Global Initiative for Chronic Obstructive Lung Disease; Available at: www.goldcopd.com
Badgett RG, Tanaka DJ, Hunt DK et al (1993) Can moderate chronic obstructive pulmonary disease be diagnosed by historical and physical findings alone? Am J Med 94(2):188–196
Thurlbeck WM, Simon G (1978) Radiographic appearance of the chest in emphysema. Am J Roentgenol 130(3):429–440
Pellegrino R, Viegi G, Brusasco V et al (2005) Interpretative strategies for lung function tests. Eur Respir J 26:948–968
Calverley PMA, Pearson MG (2003) Clinical and laboratory assessment. In: Calverley PMA, MacNee W, Rennard SI, Pride NB (eds) Chronic obstructive pulmonary disease, 2nd edn. Arnold, London, pp 282–309
Hardie JA, Buist AS, Vollmer WM et al (2002 November 1) Risk of over-diagnosis of COPD in asymptomatic elderly never-smokers. Eur Respir J 20(5):1117–1122
Akpinar-Elci M, Fedan KB, Enright PL (2006 February 1) FEV6 as a surrogate for FVC in detecting airways obstruction and restriction in the workplace. Eur Respir J 27(2):374–377
Vandevoorde J, Verbanck S, Schuermans D, Kartounian J, Vincken W (2006 February 1) Obstructive and restrictive spirometric patterns: fixed cut-offs for FEV1/FEV6 and FEV6. Eur Respir J 27(2):378–383
Vandevoorde J, Verbanck S, Schuermans D, Kartounian J, Vincken W (2005 May) FEV1/FEV6 and FEV6 as an alternative for FEV1/FVC and FVC in the spirometric detection of airway obstruction and restriction. Chest 127(5):1560–1564
Hansen JE, Sun XG, Wasserman K (2006 June) Should forced expiratory volume in six seconds replace forced vital capacity to detect airway obstruction? Eur Respir J 27(6):1244–1250
Zielinski J, Bednarek M, Gorecka D et al (2006 April 1) Increasing COPD awareness. Eur Respir J 27(4):833–852
Zielinski J, Bednarek M (2001 March 1) Early detection of COPD in a high-risk population using spirometric screening. Chest 119(3):731–736
Stratelis G, Jakobsson P, Molstad S, Zetterstrom O (2004) Early detection of COPD in primary care: screening by invitation of smokers aged 40 to 55 years. Br J Gen Pract 54(500):201–206
Gorecka D, Bednarek M, Nowinski A et al (2003 June 1) Diagnosis of airflow limitation combined with smoking cessation advice increases stop-smoking rate. Chest 123(6):1916–1923
Walker PP, Mitchell P, Diamantea F, Warburton CJ, Davies L (2006) Effect of primary-care spirometry on the diagnosis and management of COPD. Eur Respir J 28(5):945–952
Wolkove N, Dajczman E, Colacone A, Kreisman H (1989 December) The relationship between pulmonary function and dyspnea in obstructive lung disease. Chest 96(6):1247–1251
Jones PW, Baveystock CM, Littlejohns P (1989) Relationships between general health measured with the sickness impact profile and respiratory symptoms, physiological measures, and mood in patients with chronic airflow limitation. Am Rev Respir Dis 140(6):1538–1543
Sin DD, Jones RL, Mannino DM, Paul Man SF (2004 August 15) Forced expiratory volume in 1 second and physical activity in the general population. Am J Med 117(4):270–273
LoRusso TJ, Belman MJ, Elashoff JD, Koerner SK (1993 December 1) Prediction of maximal exercise capacity in obstructive and restrictive pulmonary disease. Chest 104(6):1748–1754
Hay JG, Stone P, Carter J et al (1992 June) Bronchodilator reversibility, exercise performance and breathlessness in stable chronic obstructive pulmonary disease. Eur Respir J 5(6):659–664
Bauerle O, Chrusch CA, Younes M (1998 January) Mechanisms by which COPD affects exercise tolerance. Am J Respir Crit Care Med 157(1):57–68
Carlson DJ, Ries AL, Kaplan RM (1991 August) Prediction of maximum exercise tolerance in patients with COPD. Chest 100(2):307–311
O’Donnell DE, Lam M, Webb KA (1998 November 1) Measurement of symptoms, lung hyperinflation, and endurance during exercise in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 158(5):1557–1565
Chrystyn H, Mulley BA, Peake MD (1988 December 10) Dose response relation to oral theophylline in severe chronic obstructive airways disease. BMJ 297(6662):1506–1510
Belman MJ, Botnick WC, Shin JW (1996 March 1) Inhaled bronchodilators reduce dynamic hyperinflation during exercise in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 153(3):967–975
Mannino DM, Buist AS, Petty TL, Enright PL, Redd SC (2003) Lung function and mortality in the United States: data from the First National Health and Nutrition Examination Survey follow up study. Thorax 58(5):388–393
Anthonisen NR, Wright EC, Hodgkin JE (1986) Prognosis in chronic obstructive pulmonary disease. Am Rev Respir Dis 133(1):14–20
Stavem K, Aaser E, Sandvik L et al (2005 April 1) Lung function, smoking and mortality in a 26-year follow-up of healthy middle-aged males. Eur Respir J 25(4):618–625
Hyatt RE (1983 July 1) Expiratory flow limitation. J Appl Physiol 55(1):1–7
Dawson SV, Elliott EA (1977 September) Wave-speed limitation on expiratory flow-a unifying concept. J Appl Physiol 43(3):498–515
Eltayara L, Becklake MR, Volta CA, Milic-Emili J (1996 December 1) Relationship between chronic dyspnea and expiratory flow limitation in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 154(6):1726–1734
Johnson BD, Weisman IM, Zeballos RJ, Beck KC (1999 August) Emerging concepts in the evaluation of ventilatory limitation during exercise: the exercise tidal flow-volume loop. Chest 116(2):488–503
Johnson BD, Reddan WG, Pegelow DF, Seow KC, Dempsey JA (1991 May) Flow limitation and regulation of functional residual capacity during exercise in a physically active aging population. Am Rev Respir Dis 143(5 Pt 1):960–967
Calverley PMA, Koulouris NG (2005 January 1) Flow limitation and dynamic hyperinflation: key concepts in modern respiratory physiology. Eur Respir J 25(1):186–199
Koulouris NG, Valta P, Lavoie A et al (1995 February 1) A simple method to detect expiratory flow limitation during spontaneous breathing. Eur Respir J 8(2):306–313
Ninane V, Leduc D, Kafi S et al (2001 May 1) Detection of expiratory flow limitation by manual compression of the abdominal wall. Am J Respir Crit Care Med 163(6):1326–1330
Mead J, Whittenberger JL (1953) Physical properties of human lungs measured during spontaneous respiration. J Appl Physiol 5(12):779–796
Dellaca RL, Santus P, Aliverti A et al (2004 February 1) Detection of expiratory flow limitation in COPD using the forced oscillation technique. Eur Respir J 23(2):232–240
Detels R, Tashkin DP, Simmons MS et al (1982 November 1) The UCLA population studies of chronic obstructive respiratory disease. 5. Agreement and disagreement of tests in identifying abnormal lung function. Chest 82(5):630–638
Hansen EF, Vestbo J, Phanareth K, Kok-Jensen A, Dirksen A (2001 March 1) Peak flow as predictor of overall mortality in asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 163(3):690–693
Vinegar A, Sinnett EE, Leith DE (1979 May) Dynamic mechanisms determine functional residual capacity in mice, Mus musculus. J Appl Physiol 46(5):867–871
Gelb AF, Gutierrez CA, Weisman IM et al (2004 December) Simplified detection of dynamic hyperinflation. Chest 126(6):1855–1860
Parker CM, Voduc N, Aaron SD, Webb KA, O’Donnell DE (2005 1) Physiological changes during symptom recovery from moderate exacerbations of COPD. Eur Respir J 26(3):420–428
Stevenson NJ, Walker PP, Costello RW, Calverley PM (2005 December 15) Lung mechanics and dyspnea during exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 172(12):1510–1516
O’Donnell DE (2006 April) Hyperinflation, dyspnea, and exercise intolerance in chronic obstructive pulmonary disease. Proc Am Thorac Soc 3(2):180–184
O’Donnell DE, Revill SM, Webb KA (2001 ) Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 164(5):770–777
Pare PD, Wiggs BJ, Coppin CA (1983) Errors in the measurement of total lung capacity in chronic obstructive lung disease. Thorax 38(6):468–471
Bohadana AB, Peslin R, Hannhart B, Teculescu D (1982 March) Influence of panting frequency on plethysmographic measurements of thoracic gas volume. J Appl Physiol 52(3):739–747
Brown R, Slutsky AS (1984 December) Frequency dependence of plethysmographic measurement of thoracic gas volume. J Appl Physiol 57(6):1865–1871
Tantucci C, Duguet A, Similowski T et al (1998 October 1) Effect of salbutamol on dynamic hyperinflation in chronic obstructive pulmonary disease patients. Eur Respir J 12(4):799–804
Diaz O, Villafranca C, Ghezzo H et al (2000 August 1) Role of inspiratory capacity on exercise tolerance in COPD patients with and without tidal expiratory flow limitation at rest. Eur Respir J 16(2):269–275
Boni E, Corda L, Franchini D et al (2002 June 1) Volume effect and exertional dyspnoea after bronchodilator in patients with COPD with and without expiratory flow limitation at rest. Thorax 57(6):528–532
Casanova C, Cote C, de Torres JP et al (2005 March 15) Inspiratory-to-total lung capacity ratio predicts mortality in patients with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 171(6):591–597
O’Donnell DE, Travers J, Webb KA, He Z, Lam Y-M, Hamilton A, Kesten S, Maltais F, Magnussen H (2009) Reliability of ventilatory parameters during cycle ergometry in multicentre trials in COPD. Eur Respir J 34(4):866–874. doi:doi:10.1183/09031936.00168708, published online 12 March 2009
O’Donnell DE, Fluge T, Gerken F et al (2004 June 1) Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD. Eur Respir J 23(6):832–840
Maltais F, Hamilton A, Marciniuk D et al (2005) Improvements in symptom-limited exercise performance over 8 h with once-daily tiotropium in patients with COPD. Chest 128(3):1168–1178
Simon G (1971) Principles of chest x-ray diagnosis, 3rd edn. Butterworth, London
Simon G, Pride NB, Jones NL, Raimondi AC (1973 January) Relation between abnormalities in the chest radiograph and changes in pulmonary function in chronic bronchitis and emphysema. Thorax 28(1):15–23
Burki NK, Krumpelman JL (1980 February) Correlation of pulmonary function with the chest roentgenogram in chronic airway obstruction. Am Rev Respir Dis 121(2):217–223
Nakano Y, Muro S, Sakai H et al (2000 September) Computed tomographic measurements of airway dimensions and emphysema in smokers. Correlation with lung function. Am J Respir Crit Care Med 162(3 Pt 1):1102–1108
de Jong PA, Muller NL, Pare PD, Coxson HO (2005 July) Computed tomographic imaging of the airways: relationship to structure and function. Eur Respir J 26(1):140–152
Park KJ, Bergin CJ, Clausen JL (1999 May 1) Quantitation of emphysema with three-dimensional CT densitometry: Comparison with two-dimensional analysis, visual emphysema scores, and pulmonary function test results. Radiology 211(2):541–547
Morrison NJ, Abboud RT, Ramadan F et al (1989 May) Comparison of single breath carbon monoxide diffusing capacity and pressure-volume curves in detecting emphysema. Am Rev Respir Dis 139(5):1179–1187
Leech JA, Martz L, Liben A, Becklake MR (1985) Diffusing capacity for carbon monoxide. The effects of different derivations of breathhold time and alveolar volume and of carbon monoxide back pressure on calculated results. Am Rev Respir Dis 132(5):1127–1129
Flynn E, O’Driscoll R (2002 July 1) Exercise testing in the consulting room. Chest 122(1):383
Hadeli KO, Siegel EM, Sherrill DL, Beck KC, Enright PL (2001 July) Predictors of oxygen desaturation during submaximal exercise in 8,000 patients. Chest 120(1):88–92
O’Donnell DE, Webb KA (1992 September) Breathlessness in patients with severe chronic airflow limitation. Physiologic correlations. Chest 102(3):824–831
Anthonisen NR, Lindgren PG, Tashkin DP et al (2005) Bronchodilator response in the lung health study over 11 yrs. Eur Respir J 26(1):45–51
Calverley PMA, Burge PS, Spencer S, Anderson JA, Jones PW (2003 August 1) Bronchodilator reversibility testing in chronic obstructive pulmonary disease. Thorax 58(8):659–664
Kerstjens HA, Brand PL, Quanjer PH et al (1993) Variability of bronchodilator response and effects of inhaled corticosteroid treatment in obstructive airways disease. Dutch CNSLD Study Group. Thorax 48(7):722–729
Tobin MJ, Hughes JA, Hutchison DC (1984 August) Effects of ipratropium bromide and fenoterol aerosols on exercise tolerance. Eur J Respir Dis 65(6):441–446
Leitch AG, Hopkin JM, Ellis DA, Merchant S, McHardy GJ (1978 December 1) The effect of aerosol ipratropium bromide and salbutamol on exercise tolerance in chronic bronchitis. Thorax 33(6):711–713
Muir JF, Benhamou D, Cuvelier A et al (2004) FEV1 reversibility does not adequately predict effect of formoterol via AerolizerR in chronic obstructive pulmonary disease. Int J Clin Pract 58(5):457–464
Tashkin D, Kesten S (2003 May 1) Long-term treatment benefits with tiotropium in COPD patients with and without short-term bronchodilator responses. Chest 123(5):1441–1449
Newton MF, O’Donnell DE, Forkert L (2002 April) Response of lung volumes to inhaled salbutamol in a large population of patients with severe hyperinflation. Chest 121(4):1042–1050
O’Donnell DE, Forkert L, Webb KA (2001 December) Evaluation of bronchodilator responses in patients with “irreversible” emphysema. Eur Respir J 18(6):914–920
O’Donnell DE, Lam M, Webb KA (1999 August 1) Spirometric correlates of improvement in exercise performance after anticholinergic therapy in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 160(2):542–549
Celli B, ZuWallack R, Wang S, Kesten S (2003 November) Improvement in resting inspiratory capacity and hyperinflation with tiotropium in COPD patients with increased static lung volumes. Chest 124(5):1743–1748
Olsen CR, Hale FC (1968 August) A method for interpreting acute response to bronchodilators from the spirogram. Am Rev Respir Dis 98(2):301–302
Boggs PB, Bhat KD, Vekovius WA, Debo MS (1982 March) The clinical significance of volume-adjusted maximal mid-expiratory flow (iso-volume FEF25–75%) in assessing airway responsiveness to inhaled bronchodilator in asthmatics. Ann Allergy 48(3):139–142
O’Donnell DE, Voduc N, Fitzpatrick M, Webb KA (2004 July 1) Effect of salmeterol on the ventilatory response to exercise in chronic obstructive pulmonary disease. Eur Respir J 24(1):86–94
Burge PS, Calverley PMA, Jones PW, Spencer S, Anderson JA (2003 August 1) Prednisolone response in patients with chronic obstructive pulmonary disease: results from the ISOLDE study. Thorax 58(8):654–658
Taube C, Lehnigk B, Paasch K et al (2000 July 1) Factor analysis of changes in dyspnea and lung function parameters after bronchodilation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 162(1):216–220
Hansen EF, Phanareth K, Laursen LC, Kok-Jensen A, Dirksen A (1999) Reversible and irreversible airflow obstruction as predictor of overall mortality in asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 159(4):1267–1271
Ortega F, Montemayor T, Sanchez A, Cabello F, Castillo J (1994 ) Role of cardiopulmonary exercise testing and the criteria used to determine disability in patients with severe chronic obstructive pulmonary disease. Am J Respir Crit Care Med 150(3):747–751
Oga T, Nishimura K, Tsukino M, Sato S, Hajiro T (2003 February 15) Analysis of the factors related to mortality in chronic obstructive pulmonary disease: role of exercise capacity and health status. Am J Respir Crit Care Med 167(4):544–549
Pollock M, Roa J, Benditt J, Celli B (1993 November) Estimation of ventilatory reserve by stair climbing. A study in patients with chronic airflow obstruction. Chest 104(5):1378–1383
McGavin CR, Artvinli M, Naoe H, McHardy GJ (1978 July 22) Dyspnoea, disability, and distance walked: comparison of estimates of exercise performance in respiratory disease. Br Med J 2(6132):241–243
Pinto-Plata VM, Cote C, Cabral H, Taylor J, Celli BR (2004 January 1) The 6-min walk distance: change over time and value as a predictor of survival in severe COPD. Eur Respir J 23(1):28–33
Wu G, Sanderson B, Bittner V (2003 July) The 6-minute walk test: How important is the learning effect? Am Heart J 146(1):129–133
Guyatt GH, Pugsley SO, Sullivan MJ et al (1984 November 1) Effect of encouragement on walking test performance. Thorax 39(11):818–822
Knox AJ, Morrison JF, Muers MF (1988 May 1) Reproducibility of walking test results in chronic obstructive airways disease. Thorax 43(5):388–392
Stevens D, Elpern E, Sharma K et al (1999 November) Comparison of hallway and treadmill six-minute walk tests. Am J Respir Crit Care Med 160(5 Pt 1):1540–1543
Singh SJ, Morgan MD, Scott S, Walters D, Hardman AE (1992 December) Development of a shuttle walking test of disability in patients with chronic airways obstruction. Thorax 47(12):1019–1024
Singh SJ, Morgan MD, Hardman AE, Rowe C, Bardsley PA (1994 November) Comparison of oxygen uptake during a conventional treadmill test and the shuttle walking test in chronic airflow limitation. Eur Respir J 7(11):2016–2020
Eaton T, Young P, Nicol K, Kolbe J (2006) The endurance shuttle walking test: a responsive measure in pulmonary rehabilitation for COPD patients. Chron Respir Dis 3(1):3–9
Onorati P, Antonucci R, Valli G et al (2003 May) Non-invasive evaluation of gas exchange during a shuttle walking test vs. a 6-min walking test to assess exercise tolerance in COPD patients. Eur J Appl Physiol 89(3–4):331–336
Revill SM, Morgan MDL, Singh SJ, Williams J, Hardman AE (1999 March 1) The endurance shuttle walk: a new field test for the assessment of endurance capacity in chronic obstructive pulmonary disease. Thorax 54(3):213–222
Revill SM, Singh SJ, Morgan MD (2000 August) Randomized controlled trial of ambulatory oxygen and an ambulatory ventilator on endurance exercise in COPD. Respir Med 94(8):778–783
Turner SE, Eastwood PR, Cecins NM, Hillman DR, Jenkins SC (2004 September) Physiologic responses to incremental and self-paced exercise in COPD: a comparison of three tests. Chest 126(3):766–773
Palange P, Forte S, Onorati P et al (2000 May 1) Ventilatory and metabolic adaptations to walking and cycling in patients with COPD. J Appl Physiol 88(5):1715–1720
O’Donnell DE, Bertley JC, Chau LK, Webb KA (1997 January) Qualitative aspects of exertional breathlessness in chronic airflow limitation: pathophysiologic mechanisms. Am J Respir Crit Care Med 155(1):109–115
Marin JM, Carrizo SJ, Gascon M et al (2001 May) Inspiratory capacity, dynamic hyperinflation, breathlessness, and exercise performance during the 6-minute-walk test in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 163(6):1395–1399
Puente-Maestu L, de Garcia PJ, Martinez-Abad Y et al (2005 August) Dyspnea, ventilatory pattern, and changes in dynamic hyperinflation related to the intensity of constant work rate exercise in COPD. Chest 128(2):651–656
O’Donnell DE, Hamilton AL, Webb KA (2006 October) Sensory-mechanical relationships during high-intensity, constant-work-rate exercise in COPD. J Appl Physiol 101(4):1025–1035
Sinderby C, Spahija J, Beck J et al (2001 June) Diaphragm activation during exercise in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 163(7):1637–1641
Bellemare F, Grassino A (1983 July) Force reserve of the diaphragm in patients with chronic obstructive pulmonary disease. J Appl Physiol 55(1 Pt 1):8–15
Stubbing DG, Pengelly LD, Morse JL, Jones NL (1980 September) Pulmonary mechanics during exercise in subjects with chronic airflow obstruction. J Appl Physiol 49(3):511–515
Vogiatzis I, Georgiadou O, Golemati S et al (2005) Patterns of dynamic hyperinflation during exercise and recovery in patients with severe chronic obstructive pulmonary disease. Thorax 60(9):723–729
Yan S, Kaminski D, Sliwinski P (1997) Reliability of inspiratory capacity for estimating end-expiratory lung volume changes during exercise in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 156(1):55–59
Aliverti A, Stevenson N, Dellaca RL et al (2004 March 1) Regional chest wall volumes during exercise in chronic obstructive pulmonary disease. Thorax 59(3):210–216
O’Donnell DE, D’Arsigny C, Fitzpatrick M, Webb KA (2002 ) Exercise hypercapnia in advanced chronic obstructive pulmonary disease: the role of lung hyperinflation. Am J Respir Crit Care Med 166(5):663–668
Ofir D, Laveneziana P, Webb KA, Lam Y-M, O’Donnell DE (2008) Mechanisms of dyspnea during cycle exercise in symptomatic patients with GOLD stage I chronic obstructive pulmonary disease. Am J Respir Crit Care Med 177(6):622–629
He Z, Lam M, Webb K, O’Donnell DE (2005) Ventilatory constraints during exercise in patients with mild COPD (abstract). Am J Respir Crit Care Med 171:A304
Celli BR, Cote CG, Marin JM et al (2004 March 4) The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. N Engl J Med 350(10):1005–1012
Landbo C, Prescott E, Lange P, Vestbo J, Almdal TP (1999 December 1) Prognostic value of nutritional status in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 160(6):1856–1861
Mostert R, Goris A, Weling-Scheepers C, Wouters EF, Schols AM (2000 September) Tissue depletion and health related quality of life in patients with chronic obstructive pulmonary disease. Respir Med 94(9):859–867
Marquis K, Debigare R, Lacasse Y et al (2002 5) Midthigh muscle cross-sectional area is a better predictor of mortality than body mass index in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 166(6):809–813
Swallow EB, Reyes D, Hopkinson NS et al (2007 February 1) Quadriceps strength predicts mortality in patients with moderate to severe chronic obstructive pulmonary disease. Thorax 62(2):115–120
Weitzenblum E, Hirth C, Ducolone A et al (1981 October 1) Prognostic value of pulmonary artery pressure in chronic obstructive pulmonary disease. Thorax 36(10):752–758
Kessler R, Faller M, Fourgaut G, Mennecier B, Weitzenblum E (1999 January 1) Predictive factors of hospitalization for acute exacerbation in a series of 64 patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 159(1):158–164
Biernacki W, Flenley DC, Muir AL, Macnee W (1988 December 1) Pulmonary hypertension and right ventricular function in patients with COPD. Chest 94(6):1169–1175
Roberts CM, Bugler JR, Melchor R, Hetzel MR, Spiro SG (1993 April) Value of pulse oximetry in screening for long-term oxygen therapy requirement. Eur Respir J 6(4):559–562
Spence DP, Hay JG, Carter J, Pearson MG, Calverley PM (1993 November 1) Oxygen desaturation and breathlessness during corridor walking in chronic obstructive pulmonary disease: effect of oxitropium bromide. Thorax 48(11):1145–1150
Martinez FJ, Foster G, Curtis JL et al (2006 June 15) Predictors of mortality in patients with emphysema and severe airflow obstruction. Am J Respir Crit Care Med 173(12):1326–1334
Ware JH, Dockery DW, Louis TA et al (1990) Longitudinal and cross-sectional estimates of pulmonary function decline in never-smoking adults. Am J Epidemiol 132(4):685–700
van Pelt W, Borsboom GJ, Rijcken B et al (1994 May) Discrepancies between longitudinal and cross-sectional change in ventilatory function in 12 years of follow-up. Am J Respir Crit Care Med 149(5):1218–1226
Mannino DM, Davis KJ (2006 June 1) Lung function decline and outcomes in an elderly population. Thorax 61(6):472–477
Anthonisen NR, Connett JE, Kiley JP et al (1994 November 16) Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1. The Lung Health Study. JAMA 272(19):1497–1505
Donaldson GC, Seemungal TAR, Bhowmik A, Wedzicha JA (2002) Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease. Thorax 57(10):847–852
Kerstjens HA, Rijcken B, Schouten JP, Postma DS (1997 September) Decline of FEV1 by age and smoking status: facts, figures, and fallacies. Thorax 52(9):820–827
Oga T, Nishimura K, Tsukino M et al (2007 January) Longitudinal deteriorations in patient reported outcomes in patients with COPD. Respir Med 101(1):146–153
Rabe KF, Bateman ED, O’Donnell D et al (2005 August 13) Roflumilast–an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trial. Lancet 366(9485):563–571
Swanney MP, Jensen RL, Crichton DA et al (2000 September) FEV(6) is an acceptable surrogate for FVC in the spirometric diagnosis of airway obstruction and restriction. Am J Respir Crit Care Med 162(3 Pt 1):917–919
Martinez FJ, de Oca MM, Whyte RI et al (1997 June) Lung-volume reduction improves dyspnea, dynamic hyperinflation, and respiratory muscle function. Am J Respir Crit Care Med 155(6):1984–1990
O’Donnell DE, McGuire M, Samis L, Webb KA (1995 December) The impact of exercise reconditioning on breathlessness in severe chronic airflow limitation. Am J Respir Crit Care Med 152(6 Pt 1):2005–2013
Leach RM, Davidson AC, Chinn S et al (1992 October) Portable liquid oxygen and exercise ability in severe respiratory disability. Thorax 47(10):781–789
Davidson AC, Leach R, George RJ, Geddes DM (1988 December) Supplemental oxygen and exercise ability in chronic obstructive airways disease. Thorax 43(12):965–971
Oga T, Nishimura K, Tsukino M et al (2000 June) The effects of oxitropium bromide on exercise performance in patients with stable chronic obstructive pulmonary disease. A comparison of three different exercise tests. Am J Respir Crit Care Med 161(6):1897–1901
Peters MM, Webb KA, O’Donnell DE (2006 July) Combined physiological effects of bronchodilators and hyperoxia on exertional dyspnoea in normoxic COPD. Thorax 61(7):559–567
Emtner M, Porszasz J, Burns M, Somfay A, Casaburi R (2003 November 1) Benefits of supplemental oxygen in exercise training in nonhypoxemic chronic obstructive pulmonary disease patients. Am J Respir Crit Care Med 168(9):1034–1042
Palange P, Valli G, Onorati P et al (2004 November) Effect of heliox on lung dynamic hyperinflation, dyspnea, and exercise endurance capacity in COPD patients. J Appl Physiol 97(5):1637–1642
Eves ND, Petersen SR, Haykowsky MJ, Wong EY, Jones RL (2006 October 1) Helium-hyperoxia, exercise, and respiratory mechanics in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 174(7):763–771
Laude EA, Duffy NC, Baveystock C et al (2006 April 15) The effect of helium and oxygen on exercise performance in chronic obstructive pulmonary disease: a randomized crossover trial. Am J Respir Crit Care Med 173(8):865–870
O’Donnell DE, Sanii R, Giesbrecht G, Younes M (1988 November) Effect of continuous positive airway pressure on respiratory sensation in patients with chronic obstructive pulmonary disease during submaximal exercise. Am Rev Respir Dis 138(5):1185–1191
O’Donnell DE, Webb KA, Bertley JC, Chau LK, Conlan AA (1996 July) Mechanisms of relief of exertional breathlessness following unilateral bullectomy and lung volume reduction surgery in emphysema. Chest 110(1):18–27
Porszasz J, Emtner M, Goto S et al (2005 October) Exercise training decreases ventilatory requirements and exercise-induced hyperinflation at submaximal intensities in patients with COPD. Chest 128(4):2025–2034
Casaburi R, Kukafka D, Cooper CB, Witek TJ Jr, Kesten S (2005 March) Improvement in exercise tolerance with the combination of tiotropium and pulmonary rehabilitation in patients with COPD. Chest 127(3):809–817
Cote CG, Celli BR (2005 October 1) Pulmonary rehabilitation and the BODE index in COPD. Eur Respir J 26(4):630–636
O’Donnell DE, Bain DJ, Webb KA (1997 February 1) Factors contributing to relief of exertional breathlessness during hyperoxia in chronic airflow limitation. Am J Respir Crit Care Med 155(2):530–535
O’Donnell DE, D’Arsigny C, Hollingworth EN, Webb KA (2000) Oxygen reduces dynamic hyperinflation and improves exercise performance in hypoxic patients with COPD. Am J Respir Crit Care Med 161:A753
Laveneziana P, O’Donnell DE (2007). The role of spirometry in evaluating therapeutic responses in advanced COPD. Dis Manage Health Outcomes 15(2): 91–100
O’Donnell DE, Ofir D, Laveneziana P (2007). Patterns of cardiopulmonary response to exercise in lung diseases. Eur Respir Mon 40:69–92
O’Donnell DE, Laveneziana P. The clinical importance of dynamic lung hyperinflation in COPD. COPD: J of COPD 3(4):219–232
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Travers, J., Laveneziana, P., O’Donnell, D.E. (2011). Physiologic Assessment of COPD. In: Hanania, N., Sharafkhaneh, A. (eds) COPD. Respiratory Medicine. Humana Press. https://doi.org/10.1007/978-1-59745-357-8_3
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Print ISBN: 978-1-58829-949-9
Online ISBN: 978-1-59745-357-8
eBook Packages: MedicineMedicine (R0)