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Radiation Therapy for Sarcomas

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Bone Pathology
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Abstract

The use of radiation therapy for the management of sarcomas is time honored; however, newer advances in the field and understanding of its limitations and problems have changed the application considerably. This chapter discusses some of these changes and then addresses certain specific bone and soft tissue tumors.

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References

  1. Hall E. Radiobiology for the Radiologist. Philadelphia: Lippincott, Williams and Wilkins; 2000.

    Google Scholar 

  2. Arai Y, Kun LE, Brooks MT, et al. Ewing’s sarcoma: local tumor control and patterns of failure following limited-volume radiation therapy. Int J Radiat Oncol Biol Phys 1991;21(6):1501–8.

    Article  PubMed  CAS  Google Scholar 

  3. Donaldson SS, Torrey M, Link MP, et al. A multidisciplinary study investigating radiotherapy in Ewing’s sarcoma: end results of POG #8346. Pediatric Oncology Group. Int J Radiat Oncol Biol Phys 1998;42(1):125–35.

    PubMed  CAS  Google Scholar 

  4. Tucker MA, D’Angio GJ, Boice JD, Jr., et al. Bone sarcomas linked to radiotherapy and chemotherapy in children. N Engl J Med 1987;317(10):588–93.

    Article  PubMed  CAS  Google Scholar 

  5. Kuttesch JF, Jr., Wexler LH, Marcus RB, et al. Second malignancies after Ewing’s sarcoma: radiation dose-dependency of secondary sarcomas. J Clin Oncol 1996;14(10):2818–25.

    PubMed  Google Scholar 

  6. Dunst J, Ahrens S, Paulussen M, et al. Second malignancies after treatment for Ewing’s sarcoma: a report of the CESS-studies. Int J Radiat Oncol Biol Phys 1998;42(2):379–84.

    Article  PubMed  CAS  Google Scholar 

  7. Donaldson SS. Ewing sarcoma: radiation dose and target volume. Pediatr Blood Cancer 2004;42(5):471–6.

    Article  PubMed  Google Scholar 

  8. Dunst J, Schuck A. Role of radiotherapy in Ewing tumors. Pediatr Blood Cancer 2004;42(5):465–70.

    Article  PubMed  Google Scholar 

  9. Donaldson SS, Meza J, Breneman JC, et al. Results from the IRS-IV randomized trial of hyperfractionated radiotherapy in children with rhabdomyosarcoma—a report from the IRSG. Int J Radiat Oncol Biol Phys 2001;51(3):718–28.

    Article  PubMed  CAS  Google Scholar 

  10. Wolden SL, Anderson JR, Crist WM, et al. Indications for radiotherapy and chemotherapy after complete resection in rhabdomyosarcoma: a report from the Intergroup Rhabdomyosarcoma Studies I to III. J Clin Oncol 1999;17(11):3468–75.

    PubMed  CAS  Google Scholar 

  11. Schuck A, Mattke AC, Schmidt B, et al. Group II rhabdomyosarcoma and rhabdomyosarcomalike tumors: is radiotherapy necessary? J Clin Oncol 2004;22(1):143–9.

    Article  PubMed  Google Scholar 

  12. Oberlin O, Rey A, Anderson J, et al. Treatment of orbital rhabdomyosarcoma: survival and late effects of treatment—results of an international workshop. J Clin Oncol 2001;19(1):197–204.

    PubMed  CAS  Google Scholar 

  13. Heyn R, Haeberlen V, Newton WA, et al. Second malignant neoplasms in children treated for rhabdomyosarcoma. Intergroup Rhabdomyosarcoma Study Committee. J Clin Oncol 1993;11(2):262–70.

    PubMed  CAS  Google Scholar 

  14. Rosenberg SA, Tepper J, Glatstein E, et al. The treatment of soft-tissue sarcomas of the extremities: prospective randomized evaluations of (1) limb-sparing surgery plus radiation therapy compared with amputation and (2) the role of adjuvant chemotherapy. Ann Surg 1982;196(3):305–15.

    Article  PubMed  CAS  Google Scholar 

  15. Yang JC, Chang AE, Baker AR, et al. Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity. J Clin Oncol 1998;16(1):197–203.

    PubMed  CAS  Google Scholar 

  16. Spiro IJ, Rosenberg AE, Springfield D, Suit H. Combined surgery and radiation therapy for limb preservation in soft tissue sarcoma of the extremity: the Massachusetts General Hospital experience. Cancer Invest 1995;13(1):86–95.

    Article  PubMed  CAS  Google Scholar 

  17. Alektiar KM, Leung D, Zelefsky MJ, Healey JH, Brennan MF. Adjuvant brachytherapy for primary high-grade soft tissue sarcoma of the extremity. Ann Surg Oncol 2002;9(1):48–56.

    Article  PubMed  Google Scholar 

  18. Zagars GK, Ballo MT, Pisters PW, et al. Prognostic factors for patients with localized soft-tissue sarcoma treated with conservation surgery and radiation therapy: an analysis of 225 patients. Cancer 2003;97(10):2530–43.

    Article  PubMed  Google Scholar 

  19. Gieschen HL, Spiro IJ, Suit HD, et al. Long-term results of intraoperative electron beam radiotherapy for primary and recurrent retroperitoneal soft tissue sarcoma. Int J Radiat Oncol Biol Phys 2001;50(1):127–31.

    Article  PubMed  CAS  Google Scholar 

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© 2009 Humana Press, a part of Springer Science+Business Media, LLC

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Maity, A. (2009). Radiation Therapy for Sarcomas. In: Khurana, J. (eds) Bone Pathology. Humana Press. https://doi.org/10.1007/978-1-59745-347-9_18

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  • DOI: https://doi.org/10.1007/978-1-59745-347-9_18

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-766-2

  • Online ISBN: 978-1-59745-347-9

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