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In Vivo Imaging of Cancer Therapy pp 85–102Cite as

Computed Tomography Measurements of Perfusion in Cancer Therapy

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Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

Computed tomography (CT) remains one of the mainstay techniques for anatomical evaluation of tumor growth and response to therapy, both in clinical practice and drug trials (see Chapter 3). Computed tomography measurements of perfusion can be added to a conventional CT examination to provide a functional response assessment within the same examination. This combined approach can overcome some of the limitations of a purely structural evaluation, such as slow response to therapy and residual nonmalignant masses, while avoiding the inconvenience to the patient and additional cost of further examinations using different imaging modalities. Furthermore, as positron emission tomography (PET) systems are now commonly integrated with CT, functional CT techniques can be combined with PET evaluations of tumor physiology using a single imaging device.

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Author information

Authors and Affiliations

  1. Brighton and Sussex Medical School, University of Sussex, Brighton, UK

    Ken Miles MD

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  1. Ken Miles MD
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Editors and Affiliations

  1. Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI

    Anthony F. Shields

  2. Manchester Molecular Imaging Center Christie Hospital NHS Trust Academic Department of Radiation Oncology, The University of Manchester Wolfson Molecular Imaging Centre, Manchester, UK

    Pat Price

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© 2007 Humana Press Inc., Totowa, NJ

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Miles, K. (2007). Computed Tomography Measurements of Perfusion in Cancer Therapy. In: Shields, A.F., Price, P. (eds) In Vivo Imaging of Cancer Therapy. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-59745-341-7_6

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  • DOI: https://doi.org/10.1007/978-1-59745-341-7_6

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-633-7

  • Online ISBN: 978-1-59745-341-7

  • eBook Packages: MedicineMedicine (R0)

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