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Zygomycosis (Mucormycosis)

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Book cover Diagnosis and Treatment of Human Mycoses

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References

  1. Roden MM, Zaoutis TE, Buchanan WL, et al. Epidemiology and outcome of zygomycosis: a review of 929 reported cases. Clin Infect Dis 2005;41:634–653.

    Article  PubMed  Google Scholar 

  2. Kauffman CA. Zygomycosis: reemergence of an old pathogen. Clin Infect Dis 2004;39:588–590.

    Article  PubMed  Google Scholar 

  3. Ribes JA, Vanover-Sams CL, Baker DJ. Zygomycetes in human disease. Clin Microbiol Rev 2000;13:236–301.

    Article  PubMed  CAS  Google Scholar 

  4. Spellberg B, Edwards J, Jr., Ibrahim A. Novel perspectives on mucormycosis: pathophysiology, presentation, and management. Clin Microbiol Rev 2005;18:556–569.

    Article  PubMed  CAS  Google Scholar 

  5. Jensen AB, Dromph KM. The causal agents of “entomophthoramycosis” belong to two different orders: a suggestion for modification of the clinical nomenclature. Clin Microbiol Infect 2005;11:249–250.

    Article  PubMed  CAS  Google Scholar 

  6. Gonzalez CE, Rinaldi MG, Sugar AM. Zygomycosis. Infect Dis Clin North Am 2002;16:895–914.

    Article  PubMed  Google Scholar 

  7. Prabhu RM, Patel R. Mucormycosis and entomophthoramycosis: a review of the clinical manifestations, diagnosis and treatment. Clin Microbiol Infect 2004;10(Suppl 1):31–47.

    Article  PubMed  Google Scholar 

  8. Jensen AB, Gargas A, Eilenberg J, Rosendahl S. Relationships of the insect-pathogenic order Entomophthorales (Zygomycota, Fungi) based on phylogenetic analyses of nuclear small subunit ribosomal DNA sequences (SSU rDNA). Fungal Genet Biol 1998;24: 325–334.

    Article  PubMed  CAS  Google Scholar 

  9. Rees JR, Pinner RW, Hajjeh RA, Brandt ME, Reingold AL. The epidemiological features of invasive mycotic infections in the San Francisco Bay area, 1992–1993: results of population-based laboratory active surveillance. Clin Infect Dis 1998;27:1138–1147.

    Article  PubMed  CAS  Google Scholar 

  10. Walsh TJ, Renshaw G, Andrews J, et al. Invasive zygomycosis due to Conidiobolus incongruus. Clin Infect Dis 1994;19:423–430.

    PubMed  CAS  Google Scholar 

  11. Kontoyiannis DP, Wessel VC, Bodey GP, Rolston KV. Zygomycosis in the 1990s in a tertiary-care cancer center. Clin Infect Dis 2000;30:851–856.

    Article  PubMed  CAS  Google Scholar 

  12. Marr KA, Carter RA, Crippa F, Wald A, Corey L. Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients. Clin Infect Dis 2002;34:909–917.

    Article  PubMed  Google Scholar 

  13. Shoham S, Levitz SM. The immune response to fungal infections. Br J Haematol 2005;129:569–582.

    Article  PubMed  Google Scholar 

  14. Ibrahim AS, Spellberg B, Avanessian V, Fu Y, Edwards Jr JE. Rhizopus oryzae adheres to, is phagocytosed by, and damages endothelial cells in vitro. Infect Immun 2005;73:778–783.

    Article  PubMed  CAS  Google Scholar 

  15. Dhiwakar M, Thakar A, Bahadur S. Improving outcomes in rhinocerebral mucormycosis—early diagnostic pointers and prognostic factors. J Laryngol Otol 2003;117:861–865.

    PubMed  CAS  Google Scholar 

  16. Talmi YP, Goldschmied-Reouven A, Bakon M, et al. Rhino-orbital and rhino-orbito-cerebral mucormycosis. Otolaryngol Head Neck Surg 2002;127:22–31.

    Article  PubMed  Google Scholar 

  17. Thajeb P, Thajeb T, Dai D. Fatal strokes in patients with rhino-orbito-cerebral mucormycosis and associated vasculopathy. Scand J Infect Dis 2004;36:643–648.

    Article  PubMed  Google Scholar 

  18. Kontoyiannis DP, Lionakis MS, Lewis RE, et al. Zygomycosis in a tertiary-care cancer center in the era of Aspergillus-active antifungal therapy: a case-control observational study of 27 recent cases. J Infect Dis 2005;191:1350–1360.

    Article  PubMed  Google Scholar 

  19. Lee FY, Mossad SB, Adal KA. Pulmonary mucormycosis: the last 30 years. Arch Intern Med 1999;159:1301–1309.

    Article  PubMed  CAS  Google Scholar 

  20. McAdams HP, Rosado de Christenson M, Strollo DC, Patz EF, Jr. Pulmonary mucormycosis: radiologic findings in 32 cases. AJR Am J Roentgenol 1997;168:1541–1548.

    PubMed  CAS  Google Scholar 

  21. Hay RJ. Mucormycosis: an infectious complication of traumatic injury. Lancet 2005;365:830–831.

    Article  PubMed  CAS  Google Scholar 

  22. Losee JE, Selber J, Vega S, Hall C, Scott G, Serletti JM. Primary cutaneous mucormycosis: guide to surgical management. Ann Plast Surg 2002;49:385–390.

    Article  PubMed  Google Scholar 

  23. Lyon GM, Smilack JD, Komatsu KK, et al. Gastrointestinal basidiobolomycosis in Arizona: clinical and epidemiological characteristics and review of the literature. Clin Infect Dis 2001;32:1448–1455.

    Article  PubMed  CAS  Google Scholar 

  24. Woodward A, McTigue C, Hogg G, Watkins A, Tan H. Mucormycosis of the neonatal gut: a “new” disease or a variant of necrotizing enterocolitis? J Pediatr Surg 1992;27:737–740.

    Article  PubMed  CAS  Google Scholar 

  25. Cuvelier I, Vogelaers D, Peleman R, et al. Two cases of disseminated mucormycosis in patients with hematological malignancies and literature review. Eur J Clin Microbiol Infect Dis 1998;17:859–863.

    Article  PubMed  CAS  Google Scholar 

  26. Maschmeyer G. Pneumonia in febrile neutropenic patients: radiologic diagnosis. Curr Opin Oncol 2001;13:229–235.

    Article  PubMed  CAS  Google Scholar 

  27. Fatterpekar G, Mukherji S, Arbealez A, Maheshwari S, Castillo M. Fungal diseases of the paranasal sinuses. Semin Ultrasound CT MR 1999;20:391–401.

    Article  PubMed  CAS  Google Scholar 

  28. Jamadar DA, Kazerooni EA, Daly BD, White CS, Gross BH. Pulmonary zygomycosis: CT appearance. J Comput Assist Tomogr 1995;19:733–738.

    Article  PubMed  CAS  Google Scholar 

  29. Reid VJ, Solnik DL, Daskalakis T, Sheka KP. Management of bronchovascular mucormycosis in a diabetic: a surgical success. Ann Thorac Surg 2004;78:1449–1451.

    Article  PubMed  Google Scholar 

  30. Hofman V, Castillo L, Betis F, Guevara N, Gari-Toussaint M, Hofman P. Usefulness of frozen section in rhinocerebral mucormycosis diagnosis and management. Pathology 2003;35:212–216.

    Article  PubMed  Google Scholar 

  31. Antachopoulos C, Roilides E. Cytokines and fungal infections. Br J Haematol 2005;129:583–596.

    Article  PubMed  CAS  Google Scholar 

  32. Pappas PG. Immunotherapy for invasive fungal infections: from bench to bedside. Drug Resist Updat 2004;7:3–10.

    Article  PubMed  CAS  Google Scholar 

  33. Gil-Lamaignere C, Simitsopoulou M, Roilides E, Maloukou A, Winn RM, Walsh TJ. Interferon-gamma and granulocyte-macrophage colony-stimulating factor augment the activity of polymorphonuclear leukocytes against medically important zygomycetes. J Infect Dis 2005;191:1180–1187.

    Article  PubMed  CAS  Google Scholar 

  34. Dannaoui E, Meletiadis J, Mouton JW, Meis JF, Verweij PE. In vitro susceptibilities of zygomycetes to conventional and new antifungals. J Antimicrob Chemother 2003;51:45–52.

    Article  PubMed  CAS  Google Scholar 

  35. Sun QN, Fothergill AW, McCarthy DI, Rinaldi MG, Graybill JR. In vitro activities of posaconazole, itraconazole, voriconazole, amphotericin B, and fluconazole against 37 clinical isolates of zygomycetes. Antimicrob Agents Chemother 2002;46:1581–1582.

    Article  PubMed  CAS  Google Scholar 

  36. Singh J, Rimek D, Kappe R. In vitro susceptibility of 15 strains of zygomycetes to nine antifungal agents as determined by the NCCLS M38-A microdilution method. Mycoses 2005;48:246–250.

    Article  PubMed  CAS  Google Scholar 

  37. Gleissner B, Schilling A, Anagnostopolous I, Siehl I, Thiel E. Improved outcome of zygomycosis in patients with hematological diseases? Leuk Lymphoma 2004;45: 1351–1360.

    Article  PubMed  CAS  Google Scholar 

  38. Walsh TJ, Hiemenz JW, Seibel NL, et al. Amphotericin B lipid complex for invasive fungal infections: analysis of safety and efficacy in 556 cases. Clin Infect Dis 1998;26:1383–1396.

    Article  PubMed  CAS  Google Scholar 

  39. Walsh TJ, Goodman JL, Pappas P, et al. Safety, tolerance, and pharmacokinetics of high-dose liposomal amphotericin B (AmBisome) in patients infected with Aspergillus species and other filamentous fungi: maximum tolerated dose study. Antimicrob Agents Chemother 2001;45:3487–3496.

    Article  PubMed  CAS  Google Scholar 

  40. Boucher HW, Groll AH, Chiou CC, Walsh TJ. Newer systemic antifungal agents: pharmacokinetics, safety and efficacy. Drugs 2004;64:1997–2020.

    Article  PubMed  CAS  Google Scholar 

  41. Dannaoui E, Meis JF, Loebenberg D, Verweij PE. Activity of posaconazole in treatment of experimental disseminated zygomycosis. Antimicrob Agents Chemother 2003;47: 3647–3650.

    Article  PubMed  CAS  Google Scholar 

  42. Sun QN, Najvar LK, Bocanegra R, Loebenberg D, Graybill JR. In vivo activity of posaconazole against Mucor spp. in an immunosuppressed-mouse model. Antimicrob Agents Chemother 2002;46:2310–2312.

    Article  PubMed  CAS  Google Scholar 

  43. Greenberg RN, Scott LJ, Vaughn HH, Ribes JA. Zygomycosis (mucormycosis): emerging clinical importance and new treatments. Curr Opin Infect Dis 2004;17:517–525.

    Article  PubMed  CAS  Google Scholar 

  44. Greenberg RN, Mullane K, van Burik JA, et al. Posaconazole as salvage therapy for zygomycosis. Antimicrob Agents Chemother 2006;50:126–133.

    Article  PubMed  CAS  Google Scholar 

  45. van Burik JA, Hare RS, Solomon HF, Corrado ML, Kontoyiannis DP. Posaconazole is effective as salvage therapy in zygomycosis: a retrospective summary of 91 cases. Clin Infect Dis 2006;42:e61–65.

    Article  PubMed  Google Scholar 

  46. Tobon AM, Arango M, Fernandez D, Restrepo A. Mucormycosis (zygomycosis) in a heart-kidney transplant recipient: recovery after posaconazole therapy. Clin Infect Dis 2003;36:1488–1491.

    Article  PubMed  Google Scholar 

  47. Garbino J, Uckay I, Amini K, Puppo M, Richter M, Lew D. Absidia posttraumatic infection: successful treatment with posaconazole. J Infect 2005;51:e135–e138.

    Article  PubMed  CAS  Google Scholar 

  48. Dupont B. Pulmonary mucormycosis (zygomycosis) in a lung transplant recipient: recovery after posaconazole therapy. Transplantation 2005;80:544–545.

    Article  PubMed  Google Scholar 

  49. John BV, Chamilos G, Kontoyiannis DP. Hyperbaric oxygen as an adjunctive treatment for zygomycosis. Clin Microbiol Infect 2005;11:515–517.

    Article  PubMed  CAS  Google Scholar 

  50. Gill AL, Bell CN. Hyperbaric oxygen: its uses, mechanisms of action and outcomes. QJM 2004;97:385–395.

    Article  PubMed  CAS  Google Scholar 

Suggested Readings

  • Gonzalez CE, Rinaldi MG, Sugar AM. Zygomycosis. Infect Dis Clin North Am 2002;16: 895–914.

    Article  PubMed  Google Scholar 

  • Greenberg RN, Scott LJ, Vaughn HH, Ribes JA. Zygomycosis (mucormycosis): emerging clinical importance and new treatments. Curr Opin Infect Dis 2004;17:517–525.

    Article  PubMed  CAS  Google Scholar 

  • Lee FY, Mossad SB, Adal KA. Pulmonary mucormycosis: the last 30 years. Arch Intern Med 1999;159:1301–1309.

    Article  PubMed  CAS  Google Scholar 

  • Prabhu RM, Patel R. Mucormycosis and entomophthoramycosis: a review of the clinical manifestations, diagnosis and treatment. Clin Microbiol Infect 2004;10 (Suppl 1):31–47.

    Article  PubMed  Google Scholar 

  • Ribes JA, Vanover-Sams CL, Baker DJ. Zygomycetes in human disease. Clin Microbiol Rev 2000;13:236–301.

    Article  PubMed  CAS  Google Scholar 

  • Roden MM, Zaoutis TE, Buchanan WL, et al. Epidemiology and outcome of zygomycosis: a review of 929 reported cases. Clin Infect Dis 2005;41:634–653.

    Article  PubMed  Google Scholar 

  • Spellberg B, Edwards Jr J, Ibrahim A. Novel perspectives on mucormycosis: pathophysiology, presentation, and management. Clin Microbiol Rev 2005;18:556–569.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Charalampos Antachopoulos MD
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  2. Juan C. Gea-Banacloche MD
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  3. Thomas J. Walsh MD
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Editor information

Editors and Affiliations

  1. Infectious Disease Service, Department of Medicine, Brooke Army Medical Center, Fort Sam Houston, TX; F. Edward Hébert School of Medicine, Uniformed Services University of Health Sciences, Bethesda, MD

    Duane R. Hospenthal MD,PhD

  2. Fungus Testing Laboratory, Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX

    Michael G. Rinaldi PhD

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© 2008 Humana Press Inc.

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Antachopoulos, C., Gea-Banacloche, J.C., Walsh, T.J. (2008). Zygomycosis (Mucormycosis). In: Hospenthal, D.R., Rinaldi, M.G. (eds) Diagnosis and Treatment of Human Mycoses. Infectious Disease. Humana Press. https://doi.org/10.1007/978-1-59745-325-7_12

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