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Diabetic Neuropathy pp 153–164Cite as

Experimental Diabetic Autonomic Neuropathy

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Part of the book series: Clinical Diabetes ((CLD))

Abstract

Experimental diabetic autonomic neuropathy (DAN) recapitulates the pattern of physiological and pathological changes seen in human DAN albeit in milder form. Impaired vasoregulation occurs early. Cardiovagal function is impaired in both spontaneous and induced DAN in rodents. Baroreflex gain is modestly impaired in the rabbit. Cardiac noradrenergic innervation is reduced in DAN. Splanchnic-mesenteric vasoregulation is reduced, ascribed to prejunctional impairment of neurotransmission and impaired endothelial function. Excessive venous pooling is associated with reduced density of 5-hydroxytrytamine and tyrosine hydroxylase labeling of splanchnic veins. Arterial norepinephrine is reduced in DAN. Structural changes affecting sympathetic neurons are well-established in rodent DAN of 1 year duration. Sudomotor denervation is present in diabetic mouse and rat. Erectile dysfunction regularly occurs, related to impaired nitric oxide synthase activity.

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Author information

Authors and Affiliations

  1. Department of Neurology, Mayo Clinic, Rochester, MN

    Phillip A. Low MD

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  1. Phillip A. Low MD
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Editors and Affiliations

  1. Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

    Aristidis Veves MD, DSc

  2. Manchester Royal Infirmary and University of Manchester, Manchester, UK

    Rayaz A. Malik MBChB, PhD

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© 2007 Humana Press Inc., Totowa, NJ

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Low, P.A. (2007). Experimental Diabetic Autonomic Neuropathy. In: Veves, A., Malik, R.A. (eds) Diabetic Neuropathy. Clinical Diabetes. Humana Press. https://doi.org/10.1007/978-1-59745-311-0_9

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  • DOI: https://doi.org/10.1007/978-1-59745-311-0_9

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-626-9

  • Online ISBN: 978-1-59745-311-0

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