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Micro- and Macrovascular Disease in Diabetic Neuropathy

  • Chapter
Diabetic Neuropathy

Part of the book series: Clinical Diabetes ((CLD))

Abstract

Diabetes is often defined a “vascular disease” because of the early and extensive involvement of the vascular-tree observed in patients with diabetes and even in those at risk of developing diabetes. Both the micro- and macrocirculation are affected. Changes in the micro- and macrocirculation, both anatomical and functional, contribute to the development of diabetic neuropathy. On the other hand, the development of diabetic neuropathy also affects the vasodilatory capacity of the microcirculation. Thus, the interaction between changes in the vasculature and peripheral nerves is bidirectional and results in changes in both blood flow and neuronal function. The possible links between diabetic micro- and macrovascular alterations and nerve damage will be the focus of this chapter.

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Author information

Authors and Affiliations

  1. Microcirculation Lab, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

    Aristidis Veves MD & Antonella Caselli MD, PhD

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  1. Aristidis Veves MD
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  2. Antonella Caselli MD, PhD
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Editors and Affiliations

  1. Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

    Aristidis Veves MD, DSc

  2. Manchester Royal Infirmary and University of Manchester, Manchester, UK

    Rayaz A. Malik MBChB, PhD

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© 2007 Humana Press Inc., Totowa, NJ

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Veves, A., Caselli, A. (2007). Micro- and Macrovascular Disease in Diabetic Neuropathy. In: Veves, A., Malik, R.A. (eds) Diabetic Neuropathy. Clinical Diabetes. Humana Press. https://doi.org/10.1007/978-1-59745-311-0_15

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  • DOI: https://doi.org/10.1007/978-1-59745-311-0_15

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-626-9

  • Online ISBN: 978-1-59745-311-0

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