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Role of Betaig-h3 Gene in Carcinogenesis

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Book cover Transforming Growth Factor-β in Cancer Therapy, Volume I

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

Betaig-h3, as a secreted protein induced by transforming growth factor-β (TGF-β), has been shown to modulate cell adhesion, wound healing, apoptosis and tumorigenicity. Mutations of this gene result in single amino-acid changes in the Betaig-h3 protein and are related to the development of human corneal dystrophies. In addition, Betaig-h3 promoter is frequently silenced because of promoter methylation in human cancer cells. The data suggest that Betaig-h3 gene might play an important role in mediating the pivotal cellular functions of TGF-β signalings such as proliferation, apoptosis and anti-tumor activities.

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Authors and Affiliations

  1. Center for Radiological Research, Columbia University, New York, NY, USA

    Yongliang Zhao PhD & Tom K. Hei PhD

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  1. Yongliang Zhao PhD
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  2. Tom K. Hei PhD
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© 2008 Humana Press

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Zhao, Y., Hei, T.K. (2008). Role of Betaig-h3 Gene in Carcinogenesis. In: Transforming Growth Factor-β in Cancer Therapy, Volume I. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-59745-292-2_30

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  • DOI: https://doi.org/10.1007/978-1-59745-292-2_30

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-714-3

  • Online ISBN: 978-1-59745-292-2

  • eBook Packages: MedicineMedicine (R0)

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