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Transforming Growth Factor-β in Cancer Therapy, Volume I pp 23–35Cite as

TGF-β Signaling in Homeostasis and Cancer

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Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

TGF-β is a member of a large family of cytokines with a crucial role in embryonic development and tissue homeostasis. Disruption of the TGF-β signaling pathway has been implicated in many human diseases including cancer. In normal epithelial cells, TGF-β acts as a tumor suppressor by inhibiting cellular proliferation. During cancer progression, tumor cells escape from the TGF-β antiproliferative response either by acquiring mutations in components of the TGF-β pathway or by selectively inactivating the pathway that leads to cell cycle arrest. In the latter case, TGF-β becomes an oncogenic factor. Over the last years, some of the molecular mechanisms implicated in the TGF-β antiproliferative response have been elucidated and we are beginning to understand how TGF-β is transformed from an anti-tumorigenic factor into an oncogenic factor during cancer progression. This allows a better understanding of cancer biology and helps in the design of better therapeutic protocols against this deadly disease.

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Authors and Affiliations

  1. Medical Oncology Program, Vall d’Hebron University Hospital Research Institute, Barcelona, Spain

    Joan Seoane PhD

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  1. Joan Seoane PhD
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© 2008 Humana Press

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Seoane, J. (2008). TGF-β Signaling in Homeostasis and Cancer. In: Transforming Growth Factor-β in Cancer Therapy, Volume I. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-59745-292-2_2

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  • DOI: https://doi.org/10.1007/978-1-59745-292-2_2

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-714-3

  • Online ISBN: 978-1-59745-292-2

  • eBook Packages: MedicineMedicine (R0)

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