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Pathogenesis and Management of Venous Thromboembolism in Cancer Patients

  • Michael B. StreiffEmail author
Chapter
Part of the Cancer Drug Discovery and Development book series (CDD&D)

Abstract

One hundred and forty one years have passed since Armand Trousseau’s initial observation that venous thromboembolism (VTE) is a common manifestation of an underlying malignancy (1). Despite widespread recognition of this association and the availability of a multiple options for prevention and treatment of venous thrombosis, VTE remains a common cause of morbidity and mortality in cancer patients. The purpose of this chapter will be to review: (1) The epidemiology of VTE in cancer patients, (2) The pathogenesis of cancer-related thrombosis, (3) The prevention and treatment of VTE in the cancer patient, and (4) Special topics in VTE management including management of recurrent VTE and heparin-induced thrombocytopenia.

Keywords

Venous thromboembolism Deep venous thrombosis Pulmonary embolism Prophylaxis Treatment 

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Copyright information

© Humana Press, a part of Springer Science + Business Media, LLC 2009

Authors and Affiliations

  1. 1.Division of Hematology, Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins Medical InstitutionsBaltimoreUSA

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