Abstract
Laboratory animals play a crucial role in research discovery and technological advances, and they will continue to take part in improving the lives of people and other animals. It is incumbent upon the researcher to know his subject well in order to provide relevant information to the scientific world. In an effort to assist the biomedical researcher in gaining this knowledge, this chapter provides the following key elements: definition of types of animal models, legislative and legal requirements, criteria for choosing a model, extrapolation validity recommendations, and descriptive features for publication.
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References
Americans for Medical Progress. Everyday wonders. (Accessed August 16, 2006, at http://www.amprogress.org.)
Bernard C. Introduction to the Study of Experimental Medicine. Mineola, NY: Dover Publications, 1957.
Foundation for Biomedical Research. Nobel prizes: The payoff from animal research. (Accessed on August 30, 2006, at http://www.fbresearch.org/education/nobels.htm.)
Hau J. Animal models. In: Hau J, Van Hoosier GL, Eds. Handbook of Laboratory Animal Science, 2nd ed., Vol. II. Boca Raton, FL: CRC Press, 2003:1–9.
Connan F, Campbell IC, Katzman M, Lightman SL, Treasure J. A neurodevelopmental model for anorexia nervosa. Physiol Behav 2003;79:13–24.
Immunodeficient rodents opening new doors for investigators. Res Anim Rev 1996;1(2):1–8.
Pinkert CA. The history and theory of transgenic animals. Lab Anim 1997;26:29–34.
Yan Y, Panos JC, McCormick DJ, et al. Characterization of a novel H2A(-)E+ transgenic model susceptible to heterologous but not self thyroglobulin in autoimmune thyroiditis: Thyroiditis transfer with Vbeta8+ T cells. Cell Immunol 2001;212(1):63–70.
Meng X J. Discoveries of Animal Strains of Hepatitis E Virus: Implications for Animal Models and Zoonosis. Ithaca, NY: American College of Veterinary Pathologists and American Society for Veterinary Clinical Pathology, 2004. (Accessed at http://www.ivis.org.)
St. George-Hyslop PH, Westaway DA. Antibody clears senile plaque. Nature 1999;400:116–117.
Willner P. The validity of animal models of depression. Psychopharmacology 1984;83:1–16.
Sagvolden T, Russel VA, Aase H, Johansen EB, Farshbaf M. Rodent models of attention-deficit/hyperactivity disorder. Biol Psychiatry 2005;57:1239–1247.
Bayne K, deGreeve P. An overview of global legislation, regulation, and policies on the use of animals for scientific research, testing, or education. In: Hau J, Van Hoosier GL, Eds. Handbook of Laboratory Animal Science, 2nd ed., Vol. I. Boca Raton, FL: CRC Press, 2003:31–50.
Fleischauer AT, Ellis B, Ostorff S, Hemphill MS. The select agents and toxins interim final regulations: Applications to the small animal facility. Contemp Top Lab Anim Sci 2003;42(4):126–140.
Animal models and strains search engine. Washington, DC: Institute for Laboratory Animal Research. (Accessed August 16, 2006, at http://dels.nas.edu/ilar_n/ilarhome/search_amsst_shtml.)
Davidson MK, Lindsey JR, Davis JK. Requirements and selection of an animal model. Isr J Med Sci 1987;23:551–555.
Russell WMS, Burch RL. The Principles of Humane Experimental Technique. London: Methuen, 1959.
Environmental control for animals and plants. In: ASHRAE Handbook. Atlanta, GA: American Society of Heating, Refrigerating & Air Conditioning Engineers, Inc., 2005:Chapter 10.
Rose, MA. Environmental factors likely to impact on an animal’s well-being-an overview. In: Baker RA, Jenkin G, Mellor DJ, Eds. Improving the Well Being of Animals in the Research Environment. Adelaide, Australia: ANZCCART, 1994:284–301.
Inan SY, Aksu F. Amnesic effects of relative humidity and temperature in mice. Lab Animal 2002;31(2):40–48.
Bailey DW. Genetic drift: The problem and its possible solution by frozen-embryo storage. Ciba Found Symp 1977;291–303.
NIH guidelines for research involving recombinant DNA molecules. Bethesda, MD: National Institutes of Health, 2002.
Morton DB, Abbot D, Barclay R. Removal of blood from laboratory mammals and birds. Lab Anim 1993;27:1–22.
Weisbroth SH. Post-indigenous disease: Changing concepts of disease in laboratory rodents. Lab Anim 1996;25:25–33.
Baker DG. Natural pathogens of laboratory mice, rats, and rabbits and their effects on research. Clin Microbiol Rev 1998;11(2): 231–266.
Mouse Genome Informatics. Rules for nomenclature of mouse and rat strains, 2005. (Accessed August 30, 2006, at http://www.informatics.jax.org/mgihome/nomen/strains.shtml.)
Mouse Genome Informatics. Rules for nomenclature of genes, genetic markers, alleles, and mutations in mouse and rat, 2005. (Accessed August 30, 2006, at http://www.informatics.jax.org/ mgihome/nomen/gene.shtml.)
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© 2008 Humana Press Inc., Totowa, NJ
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Rand, M.S. (2008). Selection of Biomedical Animal Models. In: Conn, P.M. (eds) Sourcebook of Models for Biomedical Research. Humana Press. https://doi.org/10.1007/978-1-59745-285-4_2
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DOI: https://doi.org/10.1007/978-1-59745-285-4_2
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