Abstract
Eukaryotic organisms depend on the cell cycle for their survival though a cyclical biochemical process consisting of tightly controlled, enzymatically driven reactions that result in cell division and the generation of new cells. The cell cycle is regulated by kinases such as cyclin-dependent kinases (CDKs), and non-CDKs, which include the Aurora and Polo-like kinases, as well as checkpoint proteins and mitotic kinesins. The CDK family of serine-theronine kinases is a common target for genetic or epigenetic events, resulting in the amplification or overexpression of these kinases in a myriad of tumor types. Such findings make CDKs rational and attractive targets for cancer therapeutics as their inhibition could potentially result in preferential targeting of malignant cells. However, several cyclin-CDK complexes have been found to be dispensable for cell proliferation owing to functional redundancy, promiscuity, and compensatory mechanisms. Although these issues have hampered their progress into the clinic, several novel compounds are currently in various phases of clinical trial development. This chapter will introduce the role of CDKs in facilitating the cell cycle, their aberrations in malignant progression and pharmacological strategies targeting them.
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Yap, T.A., Molife, L.R., Bono, J.S.d. (2008). CDK Inhibitors as Anticancer Agents. In: Dai, W. (eds) Checkpoint Responses in Cancer Therapy. Cancer Drug Discovery and Developmentā¢. Humana Press. https://doi.org/10.1007/978-1-59745-274-8_6
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