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Use of Skeletal Myoblasts for the Treatment of Chronic Heart Failure

  • Chapter
Stem Cells And Myocardial Regeneration

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

Recent investigation of cell transplantation has provided new hope for the treatment of heart failure, a historically incurable disease. Although multiple cell types and delivery techniques have been employed, no clear consensus has been reached as to the superiority of any single method. Skeletal myoblasts have several unique properties that make them an attractive cell type for use in the clinical arena. Most importantly they are autologous, readily available, and easily harvested and expanded ex vivo. Furthermore, they can be modified genetically to optimize engraftment. Their successful use in animal studies has justified several clinical trials in the United States and Europe. Autologous engraftment of skeletal myoblasts in patients has been associated with modest improvements in cardiac function. The mechanisms by which these cells might exert their positive effect remain in question, but a direct contribution to contractile function seems unlikely. Enthusiasm for these cells has further been tempered by an apparent arrhythmogenic risk. This chapter explores the use of skeletal myoblasts for the treatment of heart failure. The preclinical and clinical data published to date are reviewed. The ultimate role of these cells in the clinical armamentarium of heart failure treatments will depend on the results of ongoing studies. Regardless of their future, the use of skeletal myoblasts has provided important insights in the burgeoning field of cell therapy for heart failure.

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Authors and Affiliations

  1. Cardiovascular Research Center, Heart Center, Montefiore Medical Center, Albert Einstein College of Medicine, New York, NY

    Anthony W. Ashton MD

  2. Department of Cardiothoracic Surgery, Heart Center, Montefiore Medical Center, Albert Einstein College of Medicine, New York, NY

    David D’Alessandro MD & Robert E. Michler MD

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  1. Anthony W. Ashton MD
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  2. David D’Alessandro MD
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  3. Robert E. Michler MD
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Editors and Affiliations

  1. Bakken Heart Brain Institute and Coronary Intensive Care Unit, The Cleveland Clinic Foundation Cleveland, OH

    Marc S. Penn MD

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Ashton, A.W., D’Alessandro, D., Michler, R.E. (2007). Use of Skeletal Myoblasts for the Treatment of Chronic Heart Failure. In: Penn, M.S. (eds) Stem Cells And Myocardial Regeneration. Contemporary Cardiology. Humana Press. https://doi.org/10.1007/978-1-59745-272-4_18

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  • DOI: https://doi.org/10.1007/978-1-59745-272-4_18

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