Abstract
Clinical neurophysiological studies are based on the recording of both spontaneous electrical activity, as with the EEG, or with stimulated responses, such as evoked potentials. The electrical signaling within these neuronal circuits is responsible for both the spontaneous and evoked electrical activity that is routinely measured in the clinical neurophysiology laboratory. This chapter will review some of the basic concepts of neuronal signaling that are important to the understanding of clinical neurophysiology.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Suggested Reading
Armstrong CM, Bezanilla F. Inactivation of the sodium channel II. Gating current experiments. J Gen Physiol 1977;70: 567–590.
Catterall WA. Structure and function of voltage-sensitive ion channels. Science 1988;242: 50–61.
Friedman LK, Sperber EF, Moshe SL, Bennett MV, Zukin RS. Developmental regulation of glutamate and GABAA receptor gene expression in rat hippocampus following kainite-induced status epilepticus. Dev Neurosci 1997;19: 529–542.
Furshpan EJ, Potter DD. Transmission at the giant motor synapses of the crayfish. J Physiol 1959;145: 289–325.
Goldman DE. Potential, impedance, and rectification in membranes. J Gen Physiol 1943;27: 37–60.
Hodgkin AL, Huxley AF. A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol 1952;117: 500–544.
Hodgkin AL, Katz B. The effect of sodium ions on the electrical activity of the giant axon of the squid. J Physiol 1949;108: 37–77.
Jessell TM, Kandel ER. Synaptic transmission: a bi-directional and a self-modifiable form of cell-cell communication. Cell 1993;72(Suppl): 1–30.
Kandel ER, Schwartz JH, Jessell TM. Principles of Neural Science. 4th ed. McGraw-Hill, New York, NY, 2000.
Unwin N. Neurotransmitter action: opening of ligand-gated ion channels. Cell 1993;72(Suppl): 31–41.
Woodhull AM. Ionic blockage of sodium channels in nerve. J Gen Physiol 1973;61: 687–708.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2007 Humana Press Inc.
About this chapter
Cite this chapter
Holmes, G.L., Khazipov, R. (2007). Basic Neurophysiology and the Cortical Basis of EEG. In: Blum, A.S., Rutkove, S.B. (eds) The Clinical Neurophysiology Primer. Humana Press. https://doi.org/10.1007/978-1-59745-271-7_2
Download citation
DOI: https://doi.org/10.1007/978-1-59745-271-7_2
Publisher Name: Humana Press
Print ISBN: 978-0-89603-996-4
Online ISBN: 978-1-59745-271-7
eBook Packages: MedicineMedicine (R0)