Electrophysiology of Polyneuropathy

  • Annabel K. Wang
  • Seward B. Rutkove


As a class, polyneuropathies are some of the most commonly presented disorders to a neuromuscular clinician. Polyneuropathies generally are of one of two forms, axonal or demyelinating. This classification is often helpful in identification of potential causes. Axonal polyneuropathies are most commonly associated with diabetes, alcohol, or toxins, including side effects of medication. Demyelinating polyneuropathies, as a whole, are much less common and can be acute or chronic, and idiopafhic or associated with a monoclonal gammopathy. Finally, hereditary neuropathies, including the various forms of Charcot-Marie-Tooth disease, have similar but somewhat distinct characteristics compared with acquired forms of polyneuropathy. Nerve conduction studies, and, to some extent, needle eletromyography (EMG), can assist with the evaluation of polyneuropathies, and can help to shorten the differential diagnosis regarding potential causes.

Key Words

Axonal polyneuropathy Charcot-Marie-Tooth demyelinating polyneuropathy diabetic polyneuropathy Guillain-Barré Syndrome polyneuropathy 


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Suggested Reading

  1. Ad Hoc Subcommittee of the American Academy of Neurology AIDS Task Force. Research criteria for diagnosis of chronic inflammatory demyelinating polyneuropathy (CIDP). Neurology 1991;41: 617–618.Google Scholar
  2. Albers JW, Kelly JJ, Jr. Acquired inflammatory demyelinating polyneuropathies: clinical and electrodiagnostic features. Muscle Nerve 1989; 12: 435–451.PubMedCrossRefGoogle Scholar
  3. Auger RG, Windebank AJ, Lucchinetti CF, Chalk CH. Role of the blink reflex in the evaluation of sensory neuronopathy. Neurology 1999;53: 407–408.PubMedGoogle Scholar
  4. Chalk CH. Acquired peripheral neuropathy. In: Acquired Neuromuscular Diseases, Vol. 15 (Pourmand R, ed.). WB Saunders, Philadelphia, PA, 1997, pp. 501–528.Google Scholar
  5. Donofrio PD, Albers JW. AAEM minimonograph #34: polyneuropathies: classification by nerve conduction studies and electromyography. Muscle Nerve 1990;13: 889–903.PubMedCrossRefGoogle Scholar
  6. England JD, Gronseth GS, Franklin G, et al. Distal symmetric polyneuropathy:a definition for clinical research. Neurology 2005;64(2): 199–207.PubMedGoogle Scholar
  7. Kimura J. Electrodiagnosis in Diseases of Nerve and Muscle: Principles and Practice, Oxford University Press, Oxford, 2001.Google Scholar
  8. Lewis RA, Sumner AJ, Shy ME. Electrophysiological features of inherited demyelinating neuropathies: a reappraisal in the era of molecular diagnosis. Muscle Nerve 2000;23: 1472–1487.PubMedCrossRefGoogle Scholar
  9. Mendell JR, Kissel JT, Cornblath JR. Diagnosis and Management of Peripheral Nerve Disorders. University Press, Oxford, England, 2001.Google Scholar
  10. Stewart JD, Low PA, Fealey RD. Distal small fiber neuropathy: results of tests of sweating and autonomic cardiovascular reflexes. Muscle Nerve 1992;15(6): 661–665.PubMedCrossRefGoogle Scholar

Copyright information

© Humana Press Inc. 2007

Authors and Affiliations

  • Annabel K. Wang
    • 1
  • Seward B. Rutkove
    • 2
  1. 1.Department of NeurologyMount Sinai School of MedicineNew York
  2. 2.Department of Neurology, Beth Israel Deaconess Medical CenterHarvard Medical SchoolBoston

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