Summary
Transsphenoidal surgery, the optimal treatment for Cushing’s disease, achieves remission in 70–90% of patients. Subsequent treatment of patients who remain hypercortisolemic includes radiation therapy or adrenalectomy. However, there is a role for shortterm primary medical therapy and for adjunctive treatment while awaiting the effects of radiotherapy. The well-studied available agents inhibit cortisol production by the adrenal gland. It would be ideal to inhibit ACTH production or secretion from the tumor; however, such neuromodulatory agents are either ineffective or have not been studied extensively. This chapter will review existing agents, their mechanism of action, efficacy, and clinical application.
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Lindsay, J.R., Nieman, L.K. (2008). Cushing’s Disease: Medical Management . In: Swearingen, B., Biller, B.M. (eds) Diagnosis and Management of Pituitary Disorders. Contemporary Endocrinology. Humana Press. https://doi.org/10.1007/978-1-59745-264-9_12
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