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Biological Approaches to Spinal Fusion

  • Chapter
Musculoskeletal Tissue Regeneration

Part of the book series: Orthopedic Biology and Medicine ((OBM))

Abstract

Bone grafting procedures are frequently performed for spinal applications in an attempt to promote successful arthrodesis. Autograft remains the gold standard grafting material. However, due to relatively limited supply and the morbidity associated with procurement of autograft, there has been a great deal of interest in developing alternative bone graft materials. Allograft and ceramic preparations are osteoconductive matrices that support bone formation, but these materials exhibit minimal osteoinductive potential. Recent research efforts have focused specifi cally on osteoinductive substances such as demineralized bone matrices, recombinant human bone morphogenetic proteins and autologous bone marrow aspirates. Since none of these materials deliver all of the elements required for bone formation when implanted alone, composite grafts, consisting of osteoinductive factors combined with an osteoconductive carrier, may prove to be more effective in stimulating spinal fusion than any single graft substitute.

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Author information

Authors and Affiliations

  1. Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT

    Andrew K. Simpson, Peter G. Whang & Jonathan N. Grauer

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  1. Andrew K. Simpson
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  2. Peter G. Whang
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  3. Jonathan N. Grauer
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Editors and Affiliations

  1. Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, USA

    William S. Pietrzak Ph.D.

  2. Biomet, Inc., Warsaw, IN, USA

    William S. Pietrzak Ph.D.

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© 2008 Humana Press, a part of Springer Science+Business Media, LLC

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Simpson, A.K., Whang, P.G., Grauer, J.N. (2008). Biological Approaches to Spinal Fusion. In: Pietrzak, W.S. (eds) Musculoskeletal Tissue Regeneration. Orthopedic Biology and Medicine. Humana Press. https://doi.org/10.1007/978-1-59745-239-7_12

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  • DOI: https://doi.org/10.1007/978-1-59745-239-7_12

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-909-3

  • Online ISBN: 978-1-59745-239-7

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