Abstract
The prevalence of heart failure (HF) rises from 2% to 3% at age 65 to more than 50% in persons older than age 80. Many of these patients have HFPEF. The condition is not uncommon in elderly women, most of whom have hypertension, diabetes mellitus, or both and often coronary heart disease (CHD). However, CHD more commonly causes systolic heart failure (SHF). Atrial fibrillation is common in the elderly, and ventricular rates even when not very rapid (120-140) may precipitate HF with a preserved ejection fraction (EF).
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References
Mauer MS, Spevack D, Burkhoff D, Kronzon I. Diastolic dysfunction: Can it be diagnosed by Doppler echocardiography? J Am Coll Cardiol 2004;44:1543–1549.
Oh, JK, Hatle L, Tajik AJ, et al. Diastolic heart failure can be diagnosed by comprehensive two-dimensional and Doppler echocardiography. J Am Coll Cardiol 2006;47:500–506.
ACC/AH A guidelines for the evaluation and management of chronic heart failure in the adult: Executive summary. J Am Coll Cardiol 2001;8:2101.
Vasan RS, Levy D. Defining diastolic heart failure. A call for standardized diagnostic criteria. Circulation 2000;101:2118.
Zile M, Brutsaert D. New concepts in diastolic dysfunction and diastolic heart failure: Part I. Diagnosis, prognosis, and measurements of diastolic function. Circulation 2002;105:1387–1393.
Hunt SA, Abraham WT, Chin MH, et al. ACC/AHA 2005guideline update for the diagnosis and management of chronic heart failure in the adult—summary article. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure). J Am Coll Cardiol 2005;46:1116–1143.
Little WC, Cheng CP. Diastolic dysfunction. Cardiol Rev 1998;6:231.
Meier-Ewert HK, Gaasch WH. What is diastolic heart failure and how do we treat it? ACC Curr J Rev Nov/Dec:52, 2001.
Topol EJ, Traill TA, Fortuin NJ. Hypertensive hypertrophic cardiomyopathy of the elderly. N Engl J Med 1985;312:277.
Khan M Gabriel. Cardiomyopathy. In: Heart Disease, Diagnosis and Therapy. Totowa, NJ, HumanaPress, 2005, pp. 443–470.
Ahmed A, Rich MW, Love TE, et al. Digoxin and reduction in mortality and hospitalization in heart failure: A comprehensive post hoc analysis of the DIG trial. Eur Heart J 2006;27:178–186.
Eichhorn EJ, Gheorghiade M. Digoxin—new perspective on an old drug. N Engl J Med 2002;47:1394.
Yusuf S, Pfeffer MA, Swedberg K, et al. Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: The CHARM-Preserved Trial. Lancet 2003;362:777–781.
Cohn JN, Tognoni G. A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure. N Engl J Med 2001;345:1667–1675.
McMurray JJV, Ostergren J, Swedberg K, Granger CB. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: The CHARM-Added trial. Lancet 2003;362:767–771.
Pitt B, Zannad F, Remme WJ, et al. for the Randomized Evaluation Study Investigators. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med 1999;341: 709.
Pitt B, Remme W, Zannad F, et al. for the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study Investigators. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 2003;348:1309–1321.
Taylor AL, Ziesche S, Yancy C, et al. Combination of isosorbide dinitrate and hydralazine in blacks with heart failure. N Engl J Med 2004;351:2049–2057.
Maisel AS, Krishnaswamy P, Nowak RM, et al. Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure. N Engl J Med 2002;347:161.
Jourdain P, Funck F, Gueffet P, et al. Benefits of BNP plasma levels for optimizing therapy: The Systolic Heart Failure Treatment supported by BNP multicenter randomised trial (STARS-BNP). (abstr) J Am Coll Cardiol 2005;45(Suppl A):3A.
Wright SP, Doughty RN, Pearl A, et al. Plasma amino-terminal pro-brain natriuretic peptide and accuracy of heart-failure diagnosis in primary care: A randomized, controlled trial. J Am Coll Cardiol 2003; 42:1793–1800.
Sackner-Bernstein JD, Skopicki HA, Aaronson KD. Risk of worsening renal function with nesiritide in patients with acutely decompensated heart failure Circulation 2005;111:1487–1491.
Sackner-Bernstein JD, Kowalski M, Fox M, Aaronson K. Short-term risk of death after treatment with nesiritide for decompensated heart failure: A pooled analysis of randomized controlled trials. JAMA 2005;293:1900–1905.
Scirica BM, Morrow DA, Cannon CP, et al, for the PROVE IT-TIMI 22 Investigators. Intensive statin therapy and the risk of hospitalization for heart failure after an acute coronary syndrome in the PROVE IT-TIMI 22 Study. J Am Coll Cardiol 2006;47:2326–2331.
Sola S, Mir MQS, Lerakis S, et al. Atorvastatin improves left ventricular systolic function and serum markers of inflammation in nonischemic heart failure. J Am Coll Cardiol 2006;47:332–337.
Ramasubbu K, Mann DL. The emerging role of statins in the treatment of heart failure. J Am Coll Cardiol 2006;47:342–344.
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Gheorghiade M, van Veldhuisen DJ, Colucci WS. Contemporary use of digoxin in the management of cardiovascular disorders. Circulation 2006;113:2556–2564.
Ramasubbu K, Mann DL. The emerging role of statins in the treatment of heart failure. J Am Coll Cardiol 2006;47:342–344.
Scirica BM, Morrow DA, Cannon CP, et al, for the PROVE IT-TIMI 22 Investigators. Intensive statin therapy and the risk of hospitalization for heart failure after an acute coronary syndrome in the PROVE IT-TIMI 22 Study. J Am Coll Cardiol 2006;47:2326–2331.
Stevens LA, Coresh J, Greene T. Assessing kidney function—measured and estimated glomerular filtration rate. N Engl J Med 2006;354:2473–2483.
Taylor AL, Ziesche S, Yancy C, et al. Combination of isosorbide dinitrate and hydralazine in blacks with heart failure. N Engl J Med 2004;351:2049–2057.
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(2007). Heart Failure Controversies. In: Cardiac Drug Therapy. Contemporary Cardiology. Humana Press. https://doi.org/10.1007/978-1-59745-238-0_13
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DOI: https://doi.org/10.1007/978-1-59745-238-0_13
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