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Interventional Radiotherapy

  • Chapter
Regional Cancer Therapy

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

Brachytherapy is an established technique inradiation oncology. The radiation source is placed into the tissue, next to or directly into the tumor. In contrast to percutaneous implantation of applicators into superficial tumors or insertion of applicators into body cavities, interventional minimally invasive application of brachytherapy addresses the internal organs, particularly the liver, which is a common site of metastatic and primary tumor manifestations. For interventional application of radiation treatment agents to hepatic malignomas, two methods are currently used: the percutaneous approach using cross-sectional imaging, usually computed tomography, for guidance of applicator positioning and radiation therapy planning purposes, and the transarterial approach, using angiographic as well as scintigraphy techniques for targeting and dosimetry. Percutaneous afterloading has been shown to be suitable for treatment of lung malignomas as well. This chapter reviews the indications, methodology, and clinical outcome of both interventional modalities, percutaneous interstitial brachytherapy and transarterial radioembolization, in hepatic malignomas.

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Author information

Authors and Affiliations

  1. Clinic for Radiation Oncology and Radiation Medicine, Charité University of Medicine, Berlin, Germany

    Enrique Lopez Hänninen MD & Timm Denecke MD

Authors
  1. Enrique Lopez Hänninen MD
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  2. Timm Denecke MD
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Editor information

Editors and Affiliations

  1. Robert-Rössle-Hospital and Tumor Institute, Charité University of Medicine, Berlin

    Peter M. Schlag MD (Professor and Head of Surgical Oncology) (Professor and Head of Surgical Oncology)

  2. Max-Delbrück-Center for Molecular Medicine, Berlin, Germany

    Peter M. Schlag MD (Professor and Head of Surgical Oncology) & Ulrike Stein PhD (Assistant Professor) (Professor and Head of Surgical Oncology) &  (Assistant Professor)

  3. Tumor Metastasis and Therapy Response Program, Robert-Rössle-Hospital and Tumor Institute, Charité University of Medicine, Berlin

    Ulrike Stein PhD (Assistant Professor) (Assistant Professor)

  4. Erasmus University MC—Daniel den Hoed Cancer Center, Rotterdam, The Netherlands

    Alexander M. M. Eggermont MD, PhD (Professor and Head of Surgical Oncology) (Professor and Head of Surgical Oncology)

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© 2007 Humana Press Inc., Totowa, NJ

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Hänninen, E.L., Denecke, T. (2007). Interventional Radiotherapy. In: Schlag, P.M., Stein, U., Eggermont, A.M.M. (eds) Regional Cancer Therapy. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-59745-225-0_4

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  • DOI: https://doi.org/10.1007/978-1-59745-225-0_4

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-672-6

  • Online ISBN: 978-1-59745-225-0

  • eBook Packages: MedicineMedicine (R0)

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