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Ultrasound-Guided Therapy

  • Chapter
Regional Cancer Therapy

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

Utilizing-high frequency sound waves to define internal structures, ultrasound (US) provides an opportunity not only to diagnose disease but also to target treatment to malignant tumors. US has several advantages over other radiology-assisted techniques that highlight its important role as a component of anticancer therapy. US provides an opportunity to administer therapy with real-time guidance. In other words, the physician can deliver treatment while synchronously visualizing the US images to ensure proper targeting.

By placing US transducers within gastrointestinal (GI) lumens, periluminal structures can be readily visualized with US. The concept has led to the development of rigid US probes that can provide high-quality images of perirectal organs, such as the prostate, and, in recent years, endoscopic ultrasound (EUS). The creation of these US-endoscopy hybrids permits placement of high-frequency US probes in close proximity to structures that can be difficult to image with percutaneous US. EUS is not only limited to abdominal viscera, but can also image thoracic organs as well and therefore provides the endoscopist with minimally invasive access to evaluate and potentially treat abdominal and thoracic malignancies. This chapter will discuss US-based delivery of regional cancer therapy, introducing the reader to the methods and requirements for successful treatment. Examples of therapy will be provided; however, an in-depth discussion of indications and results for specific cancers will be reserved for chapters focusing on specific regional therapies.

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References

  1. Sandhu I, Bhutani MS. Gastrointestinal endoscopic ultrasonography. Med Clin N Am 2002:86: 1289–1317.

    Article  PubMed  Google Scholar 

  2. Ohnishi K, Ohyama N, Ito S, Fujiwara K. Small hepatocellular carcinoma: treatment with US-guided intratumoral injection of acetic acid. Radiology 1994;193:747–752.

    PubMed  CAS  Google Scholar 

  3. Shiina S, Tagawa K, Unuma T, et al. Percutaneous ethanol injection therapy for hepatocellular carcinoma: a histopathologic study. Cancer 1991;68:1524–1530.

    Article  PubMed  CAS  Google Scholar 

  4. Livraghi T. Percutaneous ethanol injection of hepatocellular carcinoma: survival after 3 years in 70 patients. Ital J Gastroenterol 1992;24:72–74.

    PubMed  CAS  Google Scholar 

  5. Livraghi T, Bolondi L, Buscarini L, et al. No treatment, resection and ethanol injection in hepatocellular carcinoma: a retrospective analysis of survival in 391 patients with cirrhosis. Italian Cooperative HCC Study Group. J Hepatol 1995;22:522–526.

    Article  PubMed  CAS  Google Scholar 

  6. Amin Z, Bown SG, Lees WR. Local treatment of colorectal liver metastases: a comparison of interstitial laser photocoagulation (ILP) and percutaneous alcohol injection (PAI). Clin Radiol 1993;48:166–171.

    Article  PubMed  CAS  Google Scholar 

  7. Livraghi T, Giorgio A, Marin G, Set al. Hepatocellular carcinoma and cirrhosis in 746 patients: long-term results of percutaneous ethanol injection. Radiology 1995;197:101–108.

    PubMed  CAS  Google Scholar 

  8. Ebara M, Ohto M, Sugiura N, et al. Percutaneous ethanol injection for the treatment of small hepatocellular carcinoma. Study of 95 patients. J Gastroenterol Hepatol 1990;5:616–626.

    PubMed  CAS  Google Scholar 

  9. Di Stasi M, Buscarini L, Livraghi T, et al. Percutaneous ethanol injection in the treatment of hepatocellular carcinoma. A multicenter survey of evaluation practices and complication rates. Scand J Gastroenterol 1997;32:1168–1173.

    PubMed  Google Scholar 

  10. Koda M, Tanaka H, Murawaki Y, et al. Liver perforation: a serious complication of percutaneous acetic acid injection for hepatocellular carcinoma. Hepatogastroenterology 2000;47:1110–1112.

    PubMed  CAS  Google Scholar 

  11. Van Hoof M, Joris JP, Horsmans Y, Geubel A. Acute renal failure requiring hemodialysis after high doses percutaneous acetic acid injection for hepatocellular carcinoma. Acta Gastroenterol Belg 1999;62:49–51.

    PubMed  Google Scholar 

  12. Livraghi T, Goldberg SN, Lazzaroni S, et al. Small hepatocellular carcinoma: treatment with radio-frequency ablation versus ethanol injection. Radiology 1999;210:655–661.

    PubMed  CAS  Google Scholar 

  13. Livraghi T, Goldberg SN, Lazzaroni S, et al. Hepatocellular carcinoma: radio-frequency ablation of medium and large lesions. Radiology 2000;214:761–768.

    PubMed  CAS  Google Scholar 

  14. Rhim H, Dodd GD III. Radiofrequency thermal ablation of liver tumors. J Clin Ultrasound 1999;27:221–229.

    Article  PubMed  CAS  Google Scholar 

  15. Solbiati L, Ierace T, Goldberg SN, et al. Percutaneous US-guided radio-frequency tissue ablation of liver metastases: treatment and follow-up in 16 patients. Radiology 1997;202:195–203.

    PubMed  CAS  Google Scholar 

  16. Lees WR, Gillams AR, Schumillian C, Branda H. Hypotensive anaesthesia improved the effectiveness of radiofrequency ablation in the liver (abstr). Radiology 2000;217:228.

    Google Scholar 

  17. de Baere T, Bessoud B, Dromain C, et al. Percutaneous radiofrequency ablation of hepatic tumors during temporary venous occlusion. AJR Am J Roentgenol 2002;178:53–59.

    PubMed  Google Scholar 

  18. Rossi S, Garbagnati F, Lencioni R, et al. Percutaneous radio-frequency thermal ablation of nonresectable hepatocellular carcinoma after occlusion of tumor blood supply. Radiology 2000;217:119–126.

    PubMed  CAS  Google Scholar 

  19. Lencioni R, Cioni D, Donati F, Bartolozzi C. Combination of interventional therapies in hepatocellular carcinoma. Hepatogastroenterology 2001;48:8–14.

    PubMed  CAS  Google Scholar 

  20. Seki T, Tamai T, Nakagawa T, et al. Combination therapy with transcatheter arterial chemoembolization and percutaneous microwave coagulation therapy for hepatocellular carcinoma. Cancer 2000;89:1245–1251.

    Article  PubMed  CAS  Google Scholar 

  21. Curley SA, Izzo F, Ellis LM, Nicolas Vauthey J, Vallone P. Radiofrequency ablation of hepatocellular cancer in 110 patients with cirrhosis. Ann Surg 2000;232:381–391.

    Article  PubMed  CAS  Google Scholar 

  22. Patterson EJ, Scudamore CH, Owen DA, et al. Radiofrequency ablation of porcine liver in vivo: effects of blood flow and treatment time on lesion size. Ann Surg 1998;227:559–565.

    Article  PubMed  CAS  Google Scholar 

  23. Livraghi T, Solbiati L, Meloni MF, et al. Treatment of focal liver tumors with percutaneous radiofrequency ablation: complications encountered in a multicenter study. Radiology 2003;226: 441–451.

    Article  PubMed  Google Scholar 

  24. Goldberg SN, Gazelle GS, Compton CC, et al. Treatment of intrahepatic malignancy with radiofrequency ablation: radiologic-pathologic correlation. Cancer 2000;88:2452–2463.

    Article  PubMed  CAS  Google Scholar 

  25. Goldberg SN, Gazelle GS, Dawson SL, et al. Tissue ablation with radiofrequency: effectof probe size, gauge, duration, and temperature on lesion volume. Acad Radiol 1995;2:399–404.

    Article  PubMed  CAS  Google Scholar 

  26. Solbiati L, Goldberg SN, Ierace T, et al. Radio-frequency ablation of hepatic metastases: postprocedural assessment with a US microbubble contrast agent—early experience. Radiology 1999;211:643–649.

    PubMed  CAS  Google Scholar 

  27. Francica G, Marone G. Ultrasound-guided percutaneous treatment of hepatocellular carcinoma by radiofrequency hyperthermia with a “cooled-tip electrode.” A preliminary clinical experience. Eur J Ultrasound 1999;9:145–153.

    Article  PubMed  CAS  Google Scholar 

  28. Kainuma O, Asano T, Aoyama H, et al. Combined therapy with radiofrequency thermal ablation and intra-arterial infusion chemotherapy for hepatic metastases from colorectal cancer. Hepatogastroenterology 1999;46:1071–1077.

    PubMed  CAS  Google Scholar 

  29. Goldberg SN, Gazelle GS, Mueller PR. Thermal ablation therapy for focal malignancy: a unified approach to underlying principles, techniques, and diagnostic imaging guidance. AJR Am J Roentgenol 2000;174:323–331.

    PubMed  CAS  Google Scholar 

  30. Dodd GD 3rd, Soulen MC, Kane RA, et al. Minimally invasive treatment of malignant hepatic tumors: at the threshold of a major breakthrough. Radiographics 2000;20:9–27.

    PubMed  Google Scholar 

  31. Gazelle GS, Goldberg SN, Solbiati L, Livraghi T. Tumor ablation with radiofrequency energy. Radiology 2000;217:633–646.

    PubMed  CAS  Google Scholar 

  32. Dupuy DE, Goldberg SN. Image-guided radiofrequency tumor ablation: challenges and opportunities—part IL J Vasc Interv Radiol 2001; 12:1135–1148.

    Article  PubMed  CAS  Google Scholar 

  33. Gillams AR. Thermal ablation of liver metastases. Abdom Imaging 2001;26:361–368.

    Article  PubMed  CAS  Google Scholar 

  34. Pavlovich CP, Walther MM, Choyke PL, et al. Percutaneous radio frequency ablation of small renal tumors: initial results. J Urol 2002;167:10–15.

    Article  PubMed  Google Scholar 

  35. Gervais DA, McGovern FJ, Wood BJ, Goldberg SN, McDougal WS, Mueller PR. Radio-frequency ablation of renal cell carcinoma: early clinical experience. Radiology 2000;217:665–672.

    PubMed  CAS  Google Scholar 

  36. Dupuy DE, Zagoria RJ, Akerley W, Mayo-Smith WW, Kavanagh PV, Safran H. Percutaneous radiofrequency ablation of malignancies in the lung. AJR Am J Roentgenol 2000; 174:57–59.

    PubMed  CAS  Google Scholar 

  37. Merkle EM, Boll DT, Boaz T, et al. MRI-guided radiofrequency thermal ablation of implanted VX2 liver tumors in a rabbit model: demonstration of feasibility at 0.2 T. Magn Reson Med 1999;42: 141–149.

    Article  PubMed  CAS  Google Scholar 

  38. Boaz TL, Lewin JS, Chung YC, et al. MR monitoring of MR-guided radiofrequency thermal ablation of normal liver in an animal model. J Magn Reson Imaging 1998;8:64–69.

    Article  PubMed  CAS  Google Scholar 

  39. Friedman M, Mikityopsky I, Kan A, et al. Radiofrequency ablation of cancer. Cardiovasc Intervent Radiol 2004;27:427–434.

    Article  PubMed  Google Scholar 

  40. Decadt B, Siriwardena AK. Radiofrequency ablation of liver tumours: systematic review. Lancet Oncol 2004;5:550–560.

    Article  PubMed  Google Scholar 

  41. Takamura M, Murakami T, Shibata T, et al. Microwave coagulation therapy with interruption of hepatic blood in-or outflow: an experimental study. J Vasc Interv Radiol 2001;12:619–622.

    Article  PubMed  CAS  Google Scholar 

  42. Ishida T, Murakami T, Shibata T, et al. Percutaneous microwave tumor coagulation for hepatocellular carcinomas with interruption of segmental hepatic blood flow. AJR J Vasc Interv Radiol 2002;13: 185–191.

    Article  Google Scholar 

  43. Murakami R, Yoshimatsu S, Yamashita Y, Matsukawa T, Takahashi M, Sagara K. Treatment of hepatocellular carcinoma: value of percutaneous microwave coagulation. Am J Roentgenol 1995;164:1159–1164.

    CAS  Google Scholar 

  44. Shimada S, Hirota M, Beppu T, et al. Complications and management of microwave coagulation therapy for primary and metastatic liver tumors. Surg Today 1998;28:1130–1137.

    Article  PubMed  CAS  Google Scholar 

  45. Chen Y, Chen H, Wu M, et al. [Curative effect of percutaneous microwave coagulation therapy for hepatocellular carcinoma]. Zhonghua Zhong Liu Za Zhi 2002;24:65–67.

    PubMed  Google Scholar 

  46. Sato M, Watanabe Y, Ueda S, et al. Microwave coagulation therapy for hepatocellular carcinoma. Gastroenterology 1996;110:1507–1514.

    Article  PubMed  CAS  Google Scholar 

  47. Seki T, Wakabayashi M, Nakagawa T, et al. Percutaneous microwave coagulation therapy for solitary metastatic liver tumors from colorectal cancer: a pilot clinical study. Am J Gastroenterol 1999;94: 322–327.

    Article  PubMed  CAS  Google Scholar 

  48. Gage AA. History of cryoablation. Semin Surg Oncol 1998; 14:99–109.

    Article  PubMed  CAS  Google Scholar 

  49. Lee FT Jr, Mahvi DM, Chosy SG, et al. Hepatic cryoablation with intraoperative US guidance. Radiology 1997;202:624–632.

    PubMed  Google Scholar 

  50. Onik G, Rubinsky B, Zemel R, et al. Ultrasound-guided hepatic cryoablation in the treatment of metastatic colon carcinoma. Preliminary results. Cancer 1991;67:901–907.

    Article  PubMed  CAS  Google Scholar 

  51. Silverman SG, Tuncali K, Adams DF, et al. MR imaging-guided percutaneous cryotherapy of liver tumours: initial experience. Radiology 2000;217:657–664.

    PubMed  CAS  Google Scholar 

  52. Brewer WH, Austin RS, Capps GW, et al. Intraoperative monitoring and postoperative imaging of hepatic cryoablation. Semin Surg Oncol 1998;14:129–155.

    Article  PubMed  CAS  Google Scholar 

  53. Kuszyk BS, Choti MA, Urban B A, et al. Hepatic tumors treated by cryoablation: normal CT appearance. AJR Am J Roentgenol 1996; 166:363–368.

    PubMed  CAS  Google Scholar 

  54. Bilchik AJ, Wood TF, Allegra D, et al. Cryosurgical ablation and radiofrequency ablation for unresectable hepatic malignant neoplasms: a proposed algorithm. Arch Surg 2000;135:657–662; discussion 662-664.

    Article  PubMed  CAS  Google Scholar 

  55. Grasso A, Watkinson AF, Tibballs JM, et al. Radiofrequency ablation in the treatment of hepatocellular carcinoma—a clinical viewpoint. J Hepatol 2000;33:667–672.

    Article  PubMed  CAS  Google Scholar 

  56. Fong Y, Sun RL, Jarnagin W, Blumgart LH. An analysis of 412 cases of hepatocellular carcinoma at a Western center. Ann Surg 1999;229:790–800.

    Article  PubMed  CAS  Google Scholar 

  57. Bismuth H, Chiche L, Adam R, Castaing D, Diamond T, Dennison A. Liver resection versus transplantation for hepatocellular carcinoma in cirrhotic patients. Ann Surg 1993;218:145–151.

    Article  PubMed  CAS  Google Scholar 

  58. Ringe B, Pichlmayr R, Wittekind C, Tusch G. Surgical treatment of hepatocellular carcinoma: experience with liver resection and transplantation in 198 patients. World J Surg 1991;15:270–285.

    Article  PubMed  CAS  Google Scholar 

  59. Iwatsuki S, Starzl TE, Sheahan DG, et al. Hepatic resection versus transplantation for hepatocellular carcinoma. Ann Surg 1991;214:221–229.

    Article  PubMed  CAS  Google Scholar 

  60. Otto G, Heuschen U, Hofmann WJ, Krumm G, Hinz U, Herfarth C. Survival and recurrence after liver transplantation versus liver resection for hepatocellular carcinoma: a retrospective analysis. Ann Surg 1998;227:424–432.

    Article  PubMed  CAS  Google Scholar 

  61. Mazzaferro V, Regalia E, Doci R, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med 1996;334:693–699.

    Article  PubMed  CAS  Google Scholar 

  62. Greenway B. Hepatic metastases from colorectal cancer: resection or not. Br J Surg 1988;75:513–519.

    Article  PubMed  CAS  Google Scholar 

  63. Scheele J, Altendorf-Hofmann A, Stangle R, et al. Surgical resection of colorectal liver metastases: gold standard for solitary and radically resectable lesions [in German]. Swiss Surg 1996;Suppl 4:4–17.

    Google Scholar 

  64. Scheele J, Stangl R, Altendorf-Hofmann A, et al. Indicators of prognosis after hepatic resection for colorectal secondaries. Surgery 1991;110:13–29.

    PubMed  CAS  Google Scholar 

  65. Herrera LJ, Fernando HC, Perry Y. Radiofrequency ablation of pulmonary malignant tumors in nonsurgical candidates. J Thorac Cardiovasc Surg 2003;125:929–937.

    Article  PubMed  Google Scholar 

  66. Lee JM, Jin GY, Goldberg SN, et al., Percutaneous radiofrequency ablation for inoperable non-small cell lung cancer and metastases preliminary report. Radiology 2004;230:125–134.

    Article  PubMed  Google Scholar 

  67. Kotaro Y, Susumu K, Yoshifumi S, et al., Thoracic tumors treated with CT-guided radiofrequency ablation initial experience. Radiology 2004;231:850–857.

    Article  Google Scholar 

  68. Cosmo G, Vittorio M, Giuseppe C, et al., Radiofrequency ablation of 40 lung neoplasms preliminary results. AJR Am J Roentgenol 2004;183:361–368.

    Google Scholar 

  69. Wood B J, Abraham J, Hvizda JL, Alexander HR, Fojo T. Radiofrequency ablation of adrenal tumors and adrenocortical carcinoma metastases. Cancer 2003;97:554–560.

    Article  PubMed  Google Scholar 

  70. Oto A, Bhutani M. Introduction to diagnostic ultrasonography and endosonography, in Digital Human Anatomy and Endoscopic Ultrasonography (Bhutani M, Deutsch J, eds.), London: BC Decker, 2005:13–25.

    Google Scholar 

  71. Eisen GM, Chutkan R, Goldstein JL, et al. Role of endoscopic ultrasonography. Gastrointest Endosc 2000;52:852–889.

    PubMed  Google Scholar 

  72. Catalano MF, Van Dam J, Sivak MV, Jr. Malignant esophageal strictures: staging accuracy of endoscopic ultrasonography. Gastrointest Endosc 1995;41:535–539.

    Article  PubMed  CAS  Google Scholar 

  73. Van Dam J, Rice TW, Catalano MF, Kirby T, Sivak MV Jr. High-grade malignant stricture is predictive of esophageal tumor stage. Risks of endosonographic evaluation. Cancer 1993;71:2910–2917.

    Article  PubMed  Google Scholar 

  74. Wallace MB, Hawes RH, Sahai AV, Van Velse A, Hoffman BJ. Dilation of malignant esophageal stenosis to allow EUS guided fine-needle aspiration: safety and effect on patient management. Gastrointest Endosc 2000;51:309–313.

    Article  PubMed  CAS  Google Scholar 

  75. Eisen GM, Baron TH, Dominitz JA, et al. Guideline on the management of anticoagulation and antiplatelet therapy for endoscopic procedures. Gastrointest Endosc 2002;55:775–779.

    Article  PubMed  Google Scholar 

  76. Zuckerman MJ, Hirota WK, Adler DG, et al. ASGE guideline: the management of low-molecular-weight heparin and nonaspirin antiplatelet agents for endoscopic procedures. Gastrointest Endosc 2005;61:189–194.

    Article  PubMed  Google Scholar 

  77. Hirota WK, Petersen K, Baron TH, et al. Guidelines for antibiotic prophylaxis for GI endoscopy. Gastrointest Endosc 2003;58:475–482.

    Article  PubMed  Google Scholar 

  78. Erickson RA. EUS-guided FNA. Gastrointest Endosc 2004;60(2):267–729.

    Article  PubMed  Google Scholar 

  79. Klapman JB, Logrono R, Dye CE, Waxman I. Clinical impact of on-site cytopathology interpretation on endoscopic ultrasound-guided fine needle aspiration. Am J Gastroenterol 2003;98:1289–1294.

    Article  PubMed  Google Scholar 

  80. Wiersema MJ, Vilmann P, Giovannini M, Chang KJ, Wiersema LM. Endosonography-guided fine-needle aspiration biopsy: diagnostic accuracy and complication assessment. Gastroenterology 1997;112:1087–1095.

    Article  PubMed  CAS  Google Scholar 

  81. Chang KJ, Nguyen P, Erickson RA, Durbin TE, Katz KD. The clinical utility of endoscopic ultra-sound-guided fine-needle aspiration in the diagnosis and staging of pancreatic carcinoma. Gastrointest Endosc 1997;45:387–393.

    Article  PubMed  CAS  Google Scholar 

  82. Erickson RA, Sayage-Rabie L, Beissner RS. Factors predicting the number of EUS-guided fine-needle passes for diagnosis of pancreatic malignancies. Gastrointest Endosc 2000;51:184–190.

    Article  PubMed  CAS  Google Scholar 

  83. Layfield LJ, Bentz JS, Gopez EV. Immediate on-site interpretation of fine-needle aspiration smears: a cost and compensation analysis. Cancer 2001;93:319–322.

    Article  PubMed  CAS  Google Scholar 

  84. Mercadante S. Celiac plexus block versus analgesics in pancreatic cancer pain. Pain 1993;52: 187–192.

    Article  PubMed  CAS  Google Scholar 

  85. Kawamata M, Ishitani K, Ishikawa K, et al. Comparison between celiac plexus block and morphine treatment on quality of life in patients with pancreatic cancer pain. Pain 1996;64:597–602.

    Article  PubMed  CAS  Google Scholar 

  86. Polati E, Finco G, Gottin L, Bassi C, Pederzoli P, Ischia S. Prospective randomized double-blind trial of neurolytic coeliac plexus block in patients with pancreatic cancer. Br J Surg 1998;85:199–201.

    Article  PubMed  CAS  Google Scholar 

  87. Wiersema MJ, Wiersema LM. Endosonography-guided celiac plexus neurolysis. Gastrointest Endosc 1996;44:656–662.

    Article  PubMed  CAS  Google Scholar 

  88. Kaiser MH, Barkin J, MacIntyre JM. Pancreatic cancer. Assessment of prognosis by clinical presentation. Cancer 1985;56:397–402.

    Article  Google Scholar 

  89. Gress F, Schmitt C, Sherman S, Ikenberry S, Lehman G. A prospective randomized comparison of endoscopic ultrasound-and computed tomography-guided celiac plexus block for managing chronic pancreatitis pain. Am J Gastroenterol 1999;94:900–905.

    Article  PubMed  CAS  Google Scholar 

  90. Hoffman BJ. EUS-guided celiac plexus block/neurolysis. Gastrointest Endosc 2002;56(4 Suppl): S26–S28.

    Article  PubMed  Google Scholar 

  91. Levy MJ, Wiersema MJ. EUS-guided celiac plexus neurolysis and celiac plexus block. Gastrointest Endosc 2003;57:923–930.

    Article  PubMed  Google Scholar 

  92. Gunaratnam NT, Sarma AV, Norton ID, Wiersema MJ. A prospective study of EUS-guided celiac plexus neurolysis for pancreatic cancer pain. Gastrointest Endosc 2001;54:316–324.

    Article  PubMed  CAS  Google Scholar 

  93. Gress F, Schmitt C, Sherman S, Ciaccia D, Ikenberry S, Lehman G. Endoscopic ultrasound-guided celiac plexus block for managing abdominal pain associated with chronic pancreatitis: a prospective single center experience. Am J Gastroenterol 2001;96:409–416.

    Article  PubMed  CAS  Google Scholar 

  94. Davies DD. Incidence of major complications of neurolytic coeliac plexus block. J R Soc Med 1993;86:264–266.

    PubMed  CAS  Google Scholar 

  95. Wong GY, Brown DL. Transient paraplegia following alcohol celiac plexus block. Reg Anesth 1995;20:352–355.

    PubMed  CAS  Google Scholar 

  96. van Dongen RT, Crul BJ. Paraplegia following coeliac plexus block. Anaesthesia 1991;46:862–863.

    Article  PubMed  Google Scholar 

  97. De Conno F, Caraceni A, Aldrighetti L, et al. Paraplegia following coeliac plexus block. Pain 1993;55:383–385.

    Article  PubMed  Google Scholar 

  98. Eisenberg E, Carr DB, Chalmers TC. Neurolytic celiac plexus block for treatment of cancer pain: a meta-analysis. Anesth Analg 1995;80:290–295.

    Article  PubMed  CAS  Google Scholar 

  99. Iftikhar S, Loftus EV Jr. Gastroparesis after celiac plexus block. Am J Gastroenterol 1998;93: 2223–2225.

    Article  PubMed  CAS  Google Scholar 

  100. Chang KJ, Nguyen PT, Thompson JA, et al. Phase I clinical trial of allogeneic mixed lymphocyte culture (cytoimplant) delivered by endoscopic ultrasound-guided fine-needle injection in patients with advanced pancreatic carcinoma. Cancer 2000;88:1325–1335.

    Article  PubMed  CAS  Google Scholar 

  101. Hecht JR, Bedford R, Abbruzzese JL, et al. A phase I/II trial of intratumoral endoscopic ultrasound injection of ONYX-015 with intravenous gemcitabine in unresectable pancreatic carcinoma. Clin Cancer Res 2003;9:555–561.

    PubMed  CAS  Google Scholar 

  102. Chang K, Senzer N, Chung T, et al. A novel gene transfer therapy againstpancreatic cancer (TNFerade) delivered by endoscopic ultrasound (EUS) and percutaneous guided fine needle injection (FNI). Gastrointest Endosc 2004;59: AB92.

    Google Scholar 

  103. Gunter E, Lingenfelser T, Eitelbach F, Muller H, Ell C. EUS-guided ethanol injection for treatment of a GI stromal tumor. Gastrointest Endosc 2003;57:113–115.

    Article  PubMed  Google Scholar 

  104. Barclay RL, Perez-Miranda M, Giovannini M. EUS-guided treatment of a solid hepatic metastasis. Gastrointest Endosc 2002;55:266–270.

    Article  PubMed  Google Scholar 

  105. Gan I, Bounds B, Brugge W. EUS-guided ethanol lavage of the pancreas is feasible and safe. Gastrointest Endosc 2004;59: AB94.

    Google Scholar 

  106. Lohnert M, Doniec JM, Kovacs G, Schroder J, Dohrmann P. New method of radiotherapy for anal cancer with three-dimensional tumor reconstruction based on endoanal ultrasound and ultrasoundguided afterloading therapy. Dis Colon Rectum 1998;41:169–176.

    Article  PubMed  CAS  Google Scholar 

  107. Doniec MJ, Loehnert MS, Kovacs G, Kremer B, Grimm HA. Rectal EUS guided HDR-brachytherapy in patients with anal and perianal malignancies. Gastrointest Endosc 2000;51:AB106.

    Google Scholar 

  108. Chan HH, Nishioka NS, Mino M, et al. EUS-guided photodynamic therapy of the pancreas: a pilot study. Gastrointest Endosc 2004;59:95–99.

    Article  PubMed  Google Scholar 

  109. Goldberg SN, Mallery S, Gazelle GS, Brugge WR. EUS-guided radiofrequency ablation in the pancreas: results in a porcine model. Gastrointest Endosc 1999;50:392–401.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Internal Medicine, Division of Gastroenterology, University of Utah School of Medicine, Salt Lake City, UT

    Robert F. Wong MD

  2. Department of Radiology, University of Texas Medical Branch, Galveston, TX

    Amanjit S. Gill MD

  3. Department of Internal Medicine, Division of Gastroenterology, University of Texas Medical Branch, Galveston, TX

    Manoop S. Bhutani MD

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  1. Robert F. Wong MD
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  2. Amanjit S. Gill MD
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  3. Manoop S. Bhutani MD
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Editor information

Editors and Affiliations

  1. Robert-Rössle-Hospital and Tumor Institute, Charité University of Medicine, Berlin

    Peter M. Schlag MD (Professor and Head of Surgical Oncology) (Professor and Head of Surgical Oncology)

  2. Max-Delbrück-Center for Molecular Medicine, Berlin, Germany

    Peter M. Schlag MD (Professor and Head of Surgical Oncology) & Ulrike Stein PhD (Assistant Professor) (Professor and Head of Surgical Oncology) &  (Assistant Professor)

  3. Tumor Metastasis and Therapy Response Program, Robert-Rössle-Hospital and Tumor Institute, Charité University of Medicine, Berlin

    Ulrike Stein PhD (Assistant Professor) (Assistant Professor)

  4. Erasmus University MC—Daniel den Hoed Cancer Center, Rotterdam, The Netherlands

    Alexander M. M. Eggermont MD, PhD (Professor and Head of Surgical Oncology) (Professor and Head of Surgical Oncology)

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© 2007 Humana Press Inc., Totowa, NJ

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Wong, R.F., Gill, A.S., Bhutani, M.S. (2007). Ultrasound-Guided Therapy. In: Schlag, P.M., Stein, U., Eggermont, A.M.M. (eds) Regional Cancer Therapy. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-59745-225-0_10

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  • DOI: https://doi.org/10.1007/978-1-59745-225-0_10

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