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Prostate Cancer pp 73–86Cite as

Cancer-Host Interactions

A Paradigm Shift Brings New Understanding and New Opportunities

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Part of the book series: Contemporary Cancer Research ((CCR))

Abstract

Cancer is not a single cell disease and its existence and behavior are constantly modulated by the host. Cancer gene expression and genetics are also highly dynamic and are regulated epigenetically by the host. In this chapter, we describe the molecular pathways leading to an unusual property of cancer cells: the ability to mimic the host microenvironment, and, in particular, the characteristics of osteomimicry and vasculogenic mimicry. We also discuss the importance of host inflammatory and stem cells, which contribute to the growth and survival of cancer cells. By understanding the salient features of cancer-host interaction, novel therapeutics may be developed to target both cancer and host in the treatment of lethal prostate cancer metastases.

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Authors and Affiliations

  1. Molecular Urology and Therapeutics Program, Department of Urology, and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA

    Leland W. K. Chung PhD

  2. Molecular Urology and Therapeutics Program, Department of Urology, Emory University School of Medicine, Atlanta, GA

    Wen-Chin Huang PhD, Shian-Ying Sung PhD, Daqing Wu PhD & Valerie Odero-Marah PhD

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  1. Leland W. K. Chung PhD
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  2. Wen-Chin Huang PhD
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  3. Shian-Ying Sung PhD
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  4. Daqing Wu PhD
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  5. Valerie Odero-Marah PhD
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  6. Haiyen E. Zhau
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Editors and Affiliations

  1. Emory University School of Medicine, Atlanta, GA

    Leland W. K. Chung PhD

  2. Johns Hopkins University School of Medicine, Baltimore, MD

    William B. Isaacs PhD

  3. Prostate Cancer Foundation, Santa Monica, CA

    Jonathan W. Simons MD

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© 2007 Humana Press Inc., Totowa, NJ

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Chung, L.W.K., Huang, WC., Sung, SY., Wu, D., Odero-Marah, V., Zhau, H.E. (2007). Cancer-Host Interactions. In: Chung, L.W.K., Isaacs, W.B., Simons, J.W. (eds) Prostate Cancer. Contemporary Cancer Research. Humana Press. https://doi.org/10.1007/978-1-59745-224-3_5

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  • DOI: https://doi.org/10.1007/978-1-59745-224-3_5

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