Abstract
At The University of Texas M.D. Anderson Cancer Center, we have been investigating use of the adenovirus type 5 ElA gene as a cancer therapy for breast or ovarian cancer since 1995. ElA gene therapy is a nonimmunologic approach involving ectopic expression of a potentially therapeutic gene in cancer cells. During the late 1980s, E1A was shown to downregulate the overexpression of HER-2/neu, thus reversing the tumorigenic and metastatic phenotype of HER-2/neu-overexpressing breast and ovarian cancer cells. Since that time, E1A has also been shown to function as a tumor suppressor gene in several other types of tumor cells by inducing apoptosis and differentiation and by inhibiting metastasis regardless of HER2 expression level. This chapter highlights some of the issues and difficulties we encountered in designing clinical trials of E1A gene therapy for breast or ovarian cancer.
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© 2007 Humana Press Inc., Totowa, NJ
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Ueno, N.T., Wolf, J.K., Gershenson, D.M., Hortobagyi, G.N., Hung, MC. (2007). Trials and Tribulations in Developing Clinical Trials of Gene Therapy. In: Hunt, K.K., Vorburger, S.A., Swisher, S.G. (eds) Gene Therapy for Cancer. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-59745-222-9_21
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DOI: https://doi.org/10.1007/978-1-59745-222-9_21
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