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Gene Therapy for Cancer pp 223–241Cite as

Cytokine Gene Therapy for Genitourinary Cancer

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Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

This chapter will discuss the potential for delivery of cytokine molecules using neo-adjuvant/adjuvant gene therapy strategies to achieve antitumor efficacy. It focuses on two approaches for delivery of cytokine genes to achieve effective therapy; in situ delivery using adenoviral vectors also termed “active vaccination,” and cell based approaches using specific immune cells modified with cytokine genes. These approaches have potential advantages for prostate cancer therapy and possibly other genitourinary malignancies.

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Authors and Affiliations

  1. Scott Department of Urology, Baylor College of Medicine, Houston, TX

    Terry L. Timme PhD, Tetsuo Fujita MD, Hongyu Wang MD, PhD, Koji Naruishi DDS, Dov Kadmon MD, Robert J. Amato DO, Brian J. Miles MD & Timothy C. Thompson PhD

  2. Department of Pathology, Baylor College of Medicine, Houston, TX

    Gustavo Ayala MD & Thomas M. Wheeler MD

  3. Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX

    Bin S. Teh MD

  4. Department of Radiology, Baylor College of Medicine, Houston, TX

    E. Brian Butler MD

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  1. Terry L. Timme PhD
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  2. Tetsuo Fujita MD
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  3. Hongyu Wang MD, PhD
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  4. Koji Naruishi DDS
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  5. Dov Kadmon MD
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  7. Brian J. Miles MD
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  9. Thomas M. Wheeler MD
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  12. Timothy C. Thompson PhD
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Editors and Affiliations

  1. The University of Texas M. D. Anderson Cancer Center, Houston, TX

    Kelly K. Hunt MD  & Stephen G. Swisher MD  & 

  2. Inselspital Bern, University of Bern, Bern, Switzerland

    Stephan A. Vorburger MD, MCR

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© 2007 Humana Press Inc., Totowa, NJ

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Timme, T.L. et al. (2007). Cytokine Gene Therapy for Genitourinary Cancer. In: Hunt, K.K., Vorburger, S.A., Swisher, S.G. (eds) Gene Therapy for Cancer. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-59745-222-9_14

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  • DOI: https://doi.org/10.1007/978-1-59745-222-9_14

  • Publisher Name: Humana Press

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