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Gene Silencing Therapy Against Cancer

  • Chapter
Book cover Gene Therapy for Cancer

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

Over the past 25 yr, gene silencing therapy derived from nucleic acid-based molecules has evolved from bench research to clinical therapy. The recent discovery of RNA interference (RNAi), a mechanism by which double stranded RNAs mediate sequence-specific gene silencing, provided a new tool in the fight against cancer. The application of RNAi technology in basic cancer research will facilitate the identification and validation of potential therapeutic targets for cancer, and the elucidation of the molecular pathways governing cancer growth and development. RNAi technology could be further developed into therapeutics for cancer by selectively silencing aberrantly activated oncogenes. However, major challenges of delivery, specificity and efficacy need to be overcome before siRNAs can be used as therapeutic agents.

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Authors and Affiliations

  1. Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA

    Chao-Zhong Song MD, phD

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  1. Chao-Zhong Song MD, phD
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Editors and Affiliations

  1. The University of Texas M. D. Anderson Cancer Center, Houston, TX

    Kelly K. Hunt MD  & Stephen G. Swisher MD  & 

  2. Inselspital Bern, University of Bern, Bern, Switzerland

    Stephan A. Vorburger MD, MCR

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© 2007 Humana Press Inc., Totowa, NJ

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Song, CZ. (2007). Gene Silencing Therapy Against Cancer. In: Hunt, K.K., Vorburger, S.A., Swisher, S.G. (eds) Gene Therapy for Cancer. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-59745-222-9_11

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  • DOI: https://doi.org/10.1007/978-1-59745-222-9_11

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