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Opiate Receptors and Antagonists pp 67–80Cite as

Opioid Receptor Antagonist-Mediated Signaling in the Immune System

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Part of the book series: Contemporary Neuroscience ((CNEURO))

Abstract

An increased susceptibility to infectious diseases in the setting of opiate use has long been noted. Studies on the specific roles of opiates in immune cells using opioid agonists and antagonists reveal a broad array of effects that include altered T and B cell proliferation, antibody production, natural killer cell activity, and cytokine production. The complexity of these effects in the setting of multiple opioid receptor subtypes has only recently been recognized. Novel, receptor-specific opioid antagonists permit more robust studies on the protean effects of these agents on immune cells. This chapter will emphasize what is known about the biologic and clinical effects of opioids on immune function with a focus on the role of opioid antagonists.

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Authors and Affiliations

  1. Department of Internal Medicine, James H. Quillen College of Medicine, East Tennessee State University, Box 70622, Johnson City, TN 36714

    Jonathan Moorman, Zhi Qiang Yao, Edward J. Bilsky & Deling Yin

  2. Department of Pharmacology, University of New England College of Osteopathic Medicine, Biddeford, ME 04005

    Edward J. Bilsky

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  1. Jonathan Moorman
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  2. Zhi Qiang Yao
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  3. Edward J. Bilsky
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  4. Deling Yin
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Correspondence to Jonathan Moorman .

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Editors and Affiliations

  1. Life Sciences/Toxicology, Alkermes, Inc., Cambridge, MA, 02139, USA

    Reginald L. Dean III

  2. Department of Pharmacology, College of Osteopathic Medicine, University of New England, Biddleford, ME, 04005, USA

    Edward J. Bilsky

  3. Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, 23298, USA

    S. Stevens Negus

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Moorman, J., Yao, Z.Q., Bilsky, E.J., Yin, D. (2009). Opioid Receptor Antagonist-Mediated Signaling in the Immune System. In: Dean, R.L., Bilsky, E.J., Negus, S.S. (eds) Opiate Receptors and Antagonists. Contemporary Neuroscience. Humana Press. https://doi.org/10.1007/978-1-59745-197-0_4

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