Abstract
Magnetic resonance (MR) is clearly the accepted imaging standard for the preliminary evaluation, peri-operative management, and routine longitudinal follow-up of patients with high-grade gliomas (HGG). The purpose of this chapter is to review the imaging characteristics of HGG using conventional MR imaging techniques. Whereas the newer techniques of MR diffusion, perfusion, diffusion tensor imaging, and MR spectroscopy will be included as part of this discussion of the high grade neoplasms, the detailed concepts of such studies will be discussed elsewhere in this text.
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References
Ricci PE. Imaging of adult brain tumors. Neuroimaging Clin No Am 1999;9:651–669.
Moller-Hartmann W, Herminghaus S, Krings T, et al. Clinical application of proton magnetic resonance spectroscopy in the diagnosis of intracranial mass lesions. Neuroradiology 2003;44:371–381.
Dean BL, Drayer BP, Bird CR. Gliomas: classification with MR imaging. Radiology 1990;174:411–415.
Watanabe M, Tanaka R, Takeda N. Magnetic resonance imaging and histopathology of cerebral gliomas. Neuroradiology 1992;34:463–469.
Kondziolka D, Lunsford LD, Martinez AJ. Unreliability of contemporary neurodiagnostic imaging in evaluating suspected adult supratentorial (low grade) astrocytoma. J Neurosurg 1993;79:533–536.
Knopp EA, Cha S, Johnson G, et al. Glial neoplasms: dynamic contrast-enhanced T2*-weighted MR imaging. Radiology 1999;211:791–798.
Law M, Yang S, Wang H, et al. Glioma grading: sensitivity, specificity and predictive values of perfusion MR imaging and proton MR spectroscopic imaging compared with conventional MR imaging. AJNR Am J Neuroradiol 2003;24:1989–1998.
Ginsberg LE, Fuller GN, Hashmi M, et al. The significance of lack of MR contrast enhancement of supratentorial brain tumors in adults: histopathological evaluation of a series. Surg Neurol 1998;49:436–440.
Smirniotopoulos JG. The new WHO classification of brain tumors. Neuroimaging Clin No Am 1999;9:595–613.
McKeran RO, Thomas DGT. The clinical study of gliomas. In:Thomas DG, Graham DI, eds. Brain tumors: Scientific Basis, Clinical Investigation, and Current Therapy. London: Butterworth, 1980:194–230.
Russel D, Rubinstein L. Tumors of central nervous system origin. In: Rubinstein LJ, ed. Pathology of Tumors of the Nervous System. Baltimore, MD: Williams and Wilkins, 1989
Paulus W, Pfeifer J. Intratumoral histologic heterogeneity of gliomas. Cancer 1989;64:442–447.
Vandenberg ST. Current concepts of astrocytic tumors. J Neuropathol Exp Neurol 1992;51:644–657.
Kondziolka D, Bernstein M, Resch., et al. Significance of hemorrhage into brain tumors: clinicopathological study. J Neurosurg 1987;67:852–857.
Burger PC, Heinz ER, Shibata T, et al. Topographic anatomy and CT correlations in the untreated glioblastomas multiforme. J Neurosurg 1988;68:698–704.
Lilja A, Bertstrom K, Spannare B, et al. Reliability of CT in assessing histopathological features of malignant supratentorial gliomas. J Comput Assist Tomogr 1981;5:625.
Earnest FIV, Kelly PJ, Scheithauer BW, et al. Cerebral astrocytomas: histopathologic correlation of MR and CT contrast enhancement with stereotactic biopsy. Radiology 1988;166:823–827.
Atlas SW. Adult supratentorial tumors. Seminars in Roentgenol 1990;25:130–154.
Tovi M, Lolj a A, Erickson A. MR imaging in cerebral gliomas: tissue component analysis in correlation with histopathology of whole-brain specimens. ActaRadiol 1994;35:495–505.
Drevelegas A, Karkavelas G. High grade gliomas. In: Drevelegas A., ed. Imaging of Brain Tumors with Histological Correlations. Berlin: Springer-Verlag, 2002:109–136.
Hartmann M, Jansen O, Heiland S, et al. Restricted diffusion within ring ehnancement is not pathognomonic for brain abscess. AJNR Am J Neuroradiol 2001;22:1738–1742.
Desprechins B, Stannik T, Koerts G, et al. Use of diffusion-weighted MR imaging in the differential diagnosis between intracerebral necrotic tumors and cerebral abscesses. AJNR Am J Neuroradiol 1999;20:1252–1257.
Feigin IM, Gross SW. Sarcoma arising in glioblastoma of the brain. Am J Pathol 1955;31:633–665.
Morantz RA, Feigin I, Ransohoff J. Clinical and pathological study of 24 cases of gliosarcoma. J Neurosurg 1976;45:398–408.
Lee YY, Castillo M, Nauert C, Moser RP. Computed tomography of gliosarcoma. AJNR Am J Neuroradiol 1985;6:527–531.
Meis JM, Martz KL, Nelson JS. Mixed glioblastoma multiforme and sarcoma. A clinicopathologic study of 26 radiation therapy oncology group cases. Cancer 1991;67:2342–2349.
Beute BJ, Fobben GS, Hubschman O, et al. Cerebellar gliosarcoma: report of a probable radiation-ionduced neoplasm. AJNR Am J Neuroradiol 1991;12:554–556.
Averback P. Mixed intracranial sarcomas: rare forms and a new association with previous radiation therapy. Ann Neurol 1998;4:229–233.
Kaschten B, Flandroy P, Reznil M, et al. Radiation induced gliosarcoma. J Neurosurg 1995;83:154–162.
Marcus G, Levin DF, Rutherford GS. Malignant gliomaa following radiation therapy for unrelated primary tumor. Cancer 1986;58:886–894.
Cerame MA, Buthikonda M, Kohli CN. Extraneural metastases in gliosarcoma. A case report and review of the literature. Neurosurgery 1985;17:413–418.
Maiuri F, Stella I, Benvenuti D, et al. Cerebral gliosarcomas: correlation of computed tomographic findings, surgical aspect, pathological features and prognosis. Neurosurgery 1990;26:261–267.
Lieberman KA, Fuller CE, Caruso RD. Postradiation gliosarcoma with osteosarcomatous components. Neuroradiology 2001;43:555–558.
Ross IB, Robitaille Y, Villemure JG, Tampieri D. Diagnosis and management of gliomatosis cerebri: recent trends. Surg Neurol 1991;36:431–440.
Artigas J, Cervis-Navaro J, Iglesias JR, et al. Gliomatosis cerebri: clinical and gistological findings. Clin Neuropathol 1985;4:135–148.
Couch JR, Weiss SA. Gliomatosis cerebri: report of four cases and review of the literature. Neurology 1976;24:504–511.
Dickson DW, Horoupian DS, Thal LJ, et al. Gliomatosis cerebri presenting with hydrocephalus and dementia. AJNR Am J Neuroradiol 1988;9:200–202.
Rippe DJ, Boyko OB Fuller GN, et al. Gadopentetate-dimeglumine-enhanced MR imaging of gliomatosis cerebral: appearance mimicking leptomeningeal tumor dissemination. AJNR Am J Neuroradiol 1990;11:800–801.
Leproux F, Melanson D, Mercier C, et al. Leptomeningeal gliomatosis: MR findings. J Comput Assist Tomogr 1993;17:317–320.
Shin YM, Chang KH, Han MH, et al. Gliomatosis cerebri: comparison of MR and CT features. AJR Am J Roentgenol 1993;161:859–862.
Wilkinson IMS, Anderson JF, Holmes AE. Oligodendroglioma: an analysis of 42 cases. J Neurol Neurosurg Psychiatry 1987;50:304–312.
Chin HW, Hazel JJ, Kim TH, et al. Oligodendrogliomas I A clinical study of cerebral oligodendrogliomas. Cancer 1980;45:1458–1466.
Packer RJ, Sutton LN, Rorke LB, et al. Oligodendroglioma of the posterior fossa in childhood. Cancer 1985;56:195–199.
Pagni CA, Canavero S, Gaidolfi E. Intramedullary “eholocord”e oligodendroglioma: case report. ActaNeurochir 1991;113:96–99.
Ringertz N. Grading of gliomas. APMIS 1950;27:51–64.
Smith MT, Ludwig CL, Godfrey AD, et al. Grading of oligodendrogliomas. Cancer 1983;52:2107–2114.
Shaw EG, Scheithauer B W, O-Fallon JR, et al. Oligodendrogliomas: the Many Clinic experience. J Neurosurg 1992;76:428–434.
Burger PC, Scheithauer BW. Central nervous system. Atlas of tumor pathology. Washington, DC: Armed Forces Institute of Pathology, 1994:107–120.
Daumas-Duport C, Tucker ML, Kolles H. Oligodendrogliomas. Part II: A new grading system based on morpholoical and imaging criteria. J Neurooncol 1997;34:61–78.
Shibata T, Burger PC, Kleihaus P. Ki-67 immunoperoxidase stain as a marker for the histologic grading of nervous system tumors. Acta Neurochir Suppl 1988;43:103–106.
Chan ASY, Leung SY, Wong MP, et al. Expression of vascular endothelial growh factor and its receptors in the anaplastic progression of astrocytoma, oligodendroglioma, and ependymoma. Am J Surg Pathol 1998;22:816–826.
Cairncross JG, Ueki K, Zlatescu MC, et al. Specific genetic predictors of chemotherapeutic response and survival in patients anaplastic oligodendrogliomas. J Natl Cancer Inst 1998;90:1473–1479.
Paleologos NA, Carincross J. Treatment of oligodendroglioma: an update. Neurooncology 1999;1:61–68.
Lee YY, Van Tassel P. Intracranial oligodendrogliomas: imaging findings in 35 untreated cases. AJR Am J Roentgenol 1989;152:361–369.
Segall HD, Destian S, Nelson MD, et al. CT and MR imaging in malignant gliomas. In:Apuzzo M.I.J., ed. Malignant cerebral glioma. Park Ridge, IL: AANS Publications Committee, 1990:63–77.
Couldwell WT, DeMattia JA, Hinton DR. Oligodendroglioma. In:Kaye A.H., Law E.R., eds. Brain Tumors: an encyclopedic approach. London: Churchill Livingstone, 2001:525–540.
Burger PC. Classification, grading and patterns of spread of malignant gliomas. In: Apuzzo MLJ, ed. Malignant Cerebral Glioma. Park Ridge, IL: AANS Publications Committee, 1990:3–17.
Hajnal JV, Doran M, Hall AS, et al. MR imaging of anisotropically restricted diffusion of water in the nervous system: technical, anatomic and pathologic considerations. J Comput Assist Tomogr 1991;15:1–18.
Le Bihan D, Breton E, Lallemand D, et al. MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. Radiology 1986;161:401–408.
Chien D, Kwong KK, Gress DR, et al. MR diffusion imaging of cerebral infarction in humans. AJNR Am J Neuroradiol 1992;13:1097–1102.
Warach S, Chien D, Li W, et al. Fast magnetic resonance diffusion-wieghted imaging of acute human stroke. Neurology 1992;42:1717–1723.
Brunberg JA, Chenevert TL, McKeever PE, et al. In vivo MR determination of water diffusion coefficients and diffusion anisotropy: correlation with stgructural alteration in gliomas of the cerebral hemispheres. AJNR Am J Neuroradiol 1995;16:361–371.
Sugahara T, Korogi Y, Kochi M, et al. Usefulness of diffusion-weighted MRI with echo-planar technique in the evaluation of cellularity in gliomas. Magn Reson Med 1999;9:53–60.
Stadnik TW, Chaskis C, Michotte A, et al. Diffusion-weighted MR imaging of intracerebral masses: comparison with conventional MR imaging and histologic findings. AJNR Am J Neuroradiol 2001;22:969–976.
Castillo M, Smith JK, Kwock L, et al. Apparent diffusion coefficients in the evaluation of high-grade cerebral gliomas. AJNR Am J Neuroradiol 2001;22:60–64.
Kono K, Inoue Y, Nakayama K, et al. The role of diffusion-weighted imaging in patients with brain tumors. AJNR Am J Neuroradiol 2001;22:1081–1088.
Tsui EY, Chan JH, Ramsey RG, et al. Late temporal lobe necrosis in patients with nasopharyngeal carcinoma: evaluation with combined multi-section diffusion weighted and perfusion weighted MR imaging. Eur J Radiol 2001;39:138.
Hein PA, Eskey CJ, Dunn JF, et al. Diffusion-weighted imaging in the follow-up of treated high-grade gliomas: tumor recurrence versus radiation injury. AJNR Am J Neuroradiol 2004;25:201–209.
Guo AC, Cummings TJ, Dash RC, et al. Lymphomas and high-grade astrocytomas: comparison of water diffusibility and histologic characteristics. Radiology 2002;224:177–183.
Wakana S, Jiang H, Nagae-Poetscher LM, et al. Fiber tract-based atlas of human white matter anatomy. Radiology 2003;230:77–87.
Jellison BJ, Field AS, Medow J, et al. Diffusion tensor imaging of cerebral white matter: a pictorial review of physics, fiber tract anatomy, and tumor imaging patterns. AJNR Am J Neuroradiol 2004;25:356–369.
Moseley ME, Cohen Y, Kucharczyk J, et al. Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system. Radiology 1990;176:439–446.
Basser PJ, Matiello J, Le Bihan D. MR diffusion tensor spectroscopy and imaging. Biophys J 1994;66:259–267.
Jones DK, Simmons A, Williams SC, et al. Non-invasive assessment of axonal fiber connectivity in the human brain via diffusion tensor MRI. Magn Reson Med 1999;42:37–41.
Contouro TE, Lori NF, Cull TS, et al. Tracking neuronal fiber pathways in the living human brain. Proc Natl Acad Sci U S A 1999;96:10422–10427.
Mori S, Crain B J, Chacko BP, et al. Three dimensional tracking of axonal projections in the brain by magnetic resonance imaging. Ann Neurol 1999;45:265–269.
Basser PJ, Pajevic S, Pierpaoli C, et al. In vitro fiber tractography using DT-MRI data. Magn Reson Med 2000;44:625–632.
Jones DK, Simmons A, Williams SC, et al. Non-invasive assessment of axonal fiber connectivity in the human brain via diffusion tensor MRI. Neuroimage 2000;12:184–195.
Sinha S, Bastin ME, Whittle IR, et al. Diffusion tensor MR imaging of high-grade cerebral gliomas. AJNR Am J Neuroradiol 2002;23:520–527.
Lu S, Ahn D, Johnson G, et al. Diffusion-tensor MR imaging of intracranial neoplasia and associated peritumoral edema: intrroduction of the tumor infiltration index. Radiology 2004;232:221–228.
Nimsky C. Ganslandt O, Hastreiter P, et al. Intraoperative diffusion-tensor MR imaging: shiftging of white matter tracts during neurosurgical procedures-initial experience. Radiology 2005;234:218–225.
Witwer BP, Moftakhar R, Hasan KM, et al. Diffusion-tensor imaging of white matter tracts in patients with cerebral neoplasm. J Neurosurg 2002;97:568–575.
Tropine A, Vucurevic G, Delani P, et al. Contribution of diffusion tensor imaging to delineation of gliomas and glioblastomas. J Magn Reson Imaging 2004;20:905–912.
Lammertsma A, Wise R, Jones T. In vivo measurements of regional cerebral blood flow and blood volume in patients with brain tumours using positron emission tomography. Acta Neurochir 1983;69:5–13.
Black K, Emerick T, Hoh C, et al. Thallium-201 SPECT and positron emission tomography equal predictors of glioma grade and recurrence. Neurol Res 1994;16:93–96.
Kaplan WD, Takvorian T, Morris JH, et al. Thallium-201 brain tumor imaging: a comparative study with pathologic correlation. J Nucl Med 1990;28:47–52.
Kim KT, Black KL, Marciano D, et al. Thallium-201 SPECT imaing of brain tumors: methods and results. J Nucl Med 1990;31:965–969.
Uematsu H, Maeda M, Sadato N, et al. Blood volume of gliomas determined by double-echo dynamic perfusion-weighted MR imaging: a preliminary study. AJNR Am J Neuroradiol 2001;22:1915–1919.
Lev M, Rosen B. Clinical applications of intracranial perfusion MR imaging. Neuroimaging Clin No Am 1999;9:309–331.
Le Bas J, Kremer S, Graand S, et al. NMR perfusion imaging: applications to the study of brain tumor angiogenesis. Bull Acad Nat Med 2000;184:557–567.
Ostergaard L, Johannsen P, Host-Poulson P, et al. Cerebral blood flow measurements by magnetic resonance imaging bolus tracking: comparison with [(15)O]H2O positron emission tomography in humans. J Cereb Blood Flow Metab 1998;18:935–940.
Roberts JC, Roberts TPL. Brasch RC, et al. Quantitative measurement of microvascular permeability in human brain tumors achieved using dynamic contrast-enhanced MR imaging: correlation with histologic grade. AJNR Am J Neuroradiol 2000;21:891–899.
Roberts H, Roberts T, Bollen A, et al. Correlation of microvascular permeability derived from dynamic contrast-enhanced MR imaging with histologic grade and tumor labeling inde: xa study in human brain tumors. Acad Radiol 2001;8:384–391.
Aronen H, Gazit I, Louis D, et al. Cerebral blood volume maps of gliomas: comparison with tumor grade and histologic findings. Radiology 1994;191:41–51.
Silva A, Kim S, Garwood M. Imaging blood flow in brain tumors using arterial spin labeling. Magn Reson Med 2000;44:169–173.
Gaa J, Warach S, Wen P, et al. Noninvasive perfusion imaging of human brain tumors with EPISTAR. Eur Radiol 1996;6:518–522.
Warmuth C, Gunther M, Zimmer C. Quantification of blood flow in brain tumors: comparison of arterial spin labeling and dynamic susceptibility-weighted contrast-enhanced MR imaging. Radiology 2003;228:523–532.
Law M, Cha S, Knopp EA, et al. High-grade gliomas and solitary metastases: differentiation by using perfusion and proton spectroscopic MR imaging. Radiology 2002;222:715–721.
Roberts H, Roberts TPL, Brasch RC, et al. Quantitative measurement of microvascular permeability in human brain tumors achieved using dynamic contrast-enhanced MR imaging: correlation with histologic grade. AJNR Am J Neuroradiol 2000;21:891–899.
Wong ET, Jackson EF, Hess KR, et al. Correlation between dynamic MRI and outcome in patients with malignant gliomas. Neurology 1998;50:777–781.
Sugahara T, Korogi Y, Kochi M, et al. Correlation of MR imaging-determined cerebral blood volume maps with histologic and angiographic determination of vascularity of gliomas. AJR Am J Roentgenol 1998;171:1479–1486.
Wenz F, Rempp K, Hess T, et al. Effect of radiation on blood volume in low-grade astrocytomas and normal brain tissue: quantification with dynamic susceptibility contrast MR imaging. AJR Am J Roentgenol 1996;166:187–193.
Pardo FS, Aronen JJ, Kennedy D, et al. Functional cerebral imaging in the evaluation and radiotherapeutic treatment planning of patients with malignant glioma. Int J Radiat Oncol Biol Phys 1994;30:663–669.
Barker PB, Hearshen DO. Boska MD. Single-voxel proton MRS of the human brain at 1.5T and 3.0T. Magn Reson Med 2001;45:765–769.
Gonen O, Gruber S, Belinda S, et al. Multivixel 3D proton spectroscopy in the brain at 1.5 versus 3.0T: signalto-noise ratio and resolution comparison. AJNR Am J Neuroradiol 2001;22:1727–1731.
Birken DL, Oldendorf WH. N-acetyl-L-aspartic acid: a leterature reviw of a compound prominent in 1H spectroscopic studies of brain. Neurosci Biobehav Rev 1989;13:23–31.
Ross BD. Biochemical considerations in 1H spectroscopy. Glutamate and glutamine; myo-inositol and related metabolites. NMRBiomed 1991;4:59–53.
Howe FA, Maxwell RJ, Saunders DE, et al. Proton spectroscopy in vivo. Magn Reson Q 1993;9:31–59.
Vion-Dury J, Meyerhoff DJ, Cozzone PJ, et al. What might be the impact on neurology of the analysis of brain metabolism by in vivo magnetic resonance spectroscopy? J Neurol 1994;241:354–371.
Castillo M, Kwock L, Mukherji SK. Clinical applications in proton MR spectroscopy. AJNR Am J Neuroradiol 1996;17:1–15.
Pouwels PJW, Frahm J. Regional metabolite concentrations in human brain determined by quantitative localized proton MRS. Magn Reson Med 1998;39:53–60.
Urenjak J, Williams SR, Gadian DG, et al. Specific expression of N-acetylaspartate in neurons, oligodendrocyte-type-2 astrocyte progenitors, and immature oligodendrocytes in vitro. J Neurochem 1992;59:55–61.
Lowry OH, Berger SJ, Chi M-Y, et al. Diversity of metabolic patterns in human brain tumors-I. High energy phosphate compounds and basic composition. J Neurochem 1977;29:959–977.
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Ruggieri, P.M. (2007). Magnetic Resonance Imaging. In: Barnett, G.H. (eds) High-Grade Gliomas. Current Clinical Oncology. Humana Press. https://doi.org/10.1007/978-1-59745-185-7_6
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