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Antiangiogenic Agents in Cancer Therapy pp 371–384Cite as

Antiangiogenesis Agents in Colorectal Cancer

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Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Summary

Advanced colorectal cancer was the first human malignancy in which inhibition of angiogenesis by targeting vascular endothelial growth factor (VEGF) led to a significant survival benefit in a randomized phase III trial. Since then, bevacizumab, a monoclonal antibody against VEGF, has become a standard component of palliative medical therapy in this disease. Various other angiogenesis inhibitors, in particular, inhibitors of VEGF-receptor kinases are currently undergoing testing in clinical trials, either as single agents or in combination with chemotherapy or other targeted agents. In addition, clinical research is currently focusing on the use of anti-VEGF-therapy in the adjuvant and neoadjuvant setting, as well as its usefulness as maintenance therapy to stabilize responses achieved with conventional cytotoxic chemotherapy.

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Authors
  1. Axel Grothey MD
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Editor information

Editors and Affiliations

  1. Genzyme Corporation, Framingham, MA

    Beverly A. Teicher PhD

  2. M. D. Anderson Cancer Center, The University of Texas, Houston, TX

    Lee M. Ellis MD

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© 2008 Humana Press

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Grothey, A. (2008). Antiangiogenesis Agents in Colorectal Cancer. In: Teicher, B.A., Ellis, L.M. (eds) Antiangiogenic Agents in Cancer Therapy. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-59745-184-0_22

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  • DOI: https://doi.org/10.1007/978-1-59745-184-0_22

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-870-6

  • Online ISBN: 978-1-59745-184-0

  • eBook Packages: MedicineMedicine (R0)

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