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Tumor Blood Vessels

Structure, Function and Classification

  • Chapter
Antiangiogenic Agents in Cancer Therapy

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Summary

The tumor vasculature is largely induced by secreted VEGF-A and consists of a heterogeneous mixture of highly abnormal blood vessels. Recently, it has been possible to replicate many of these vessel types by introducing an adenovirus expressing VEGF-A164 (Ad-VEGF-A164) into mouse tissues. At least five different microvessels form in sequence from preexisting venules, each with distinctly different structural and functional properties. Mother vessels (MV) from first and evolve into several types of daugther vessels: bridged MV, capillaries, glomeruloid microvascular proliferations (GMP), and vascular malformations (VM). In addition to this angiogenic response, feeder arteries (FA) and draining veins (DV) develop from preexisting arteries and veins, respectively, to supply and drain the tumor microvasculature. This classification has helped to elucidate the steps and mechanisms by which tumors induce new blood vessels and hopefully will lead to the identification of new therapeutic targets that can improve anti-angiogenic tumor therapy.

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Authors
  1. Yineng Fu MD
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  2. Janice A. Nagy PhD
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  3. Ann M. Dvorak MD
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  4. Harold F. Dvorak MD
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Editor information

Editors and Affiliations

  1. Genzyme Corporation, Framingham, MA

    Beverly A. Teicher PhD

  2. M. D. Anderson Cancer Center, The University of Texas, Houston, TX

    Lee M. Ellis MD

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Fu, Y., Nagy, J.A., Dvorak, A.M., Dvorak, H.F. (2008). Tumor Blood Vessels. In: Teicher, B.A., Ellis, L.M. (eds) Antiangiogenic Agents in Cancer Therapy. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-59745-184-0_12

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  • DOI: https://doi.org/10.1007/978-1-59745-184-0_12

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-870-6

  • Online ISBN: 978-1-59745-184-0

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