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Drug Resistance and Emerging Targets in the Opportunistic Pathogens Toxoplasma gondii and Cryptosporidium parvum

  • Chapter
Antimicrobial Drug Resistance

Part of the book series: Infectious Disease ((ID))

T. gondii was initially described as a tropical parasite of wild rodents at the North African dependence of the Institute Pasteur in Tunis (4). Ironically, Paris, the home of Institute Pasteur, has now (and most likely had back then) one of the highest prevalences of T. gondii in humans in the world. Whereas the sexual development of the parasite is limited to cats, a large variety of birds and mammals can serve as intermediate hosts. Both oocysts shed by cats with the feces as well as tissue cysts developing in the muscle and brain of the intermediate host are infective to humans (5). Recent studies point to the overall importance of foodborne tissue cysts as a predominant source of infection; however, epidemic outbreaks of toxoplasmosis have been associated with oocyst contamination of soil or drinking water (6, 7).

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Authors and Affiliations

  1. University of Georgia Paul Coverdell Center, Athens, GA, USA

    Boris Striepen

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  1. Boris Striepen
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  1. Executive Vice President & Chief Medical Offi cer, Idenix Pharmaceuticals, Cambridge, MA, USA

    Douglas L. Mayers MD

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© 2009 Humana Press, a part of Springer Science+Business Media, LLC

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Striepen, B. (2009). Drug Resistance and Emerging Targets in the Opportunistic Pathogens Toxoplasma gondii and Cryptosporidium parvum . In: Mayers, D.L. (eds) Antimicrobial Drug Resistance. Infectious Disease. Humana Press. https://doi.org/10.1007/978-1-59745-180-2_43

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  • DOI: https://doi.org/10.1007/978-1-59745-180-2_43

  • Publisher Name: Humana Press

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