β-Lactams are considered to be among the safest, most efficacious, and most widely prescribed antibiotics for the treatment of bacterial infections. Their therapeutic use began with the introduction of benzylpenicillin (penicillin G) during World War II (1, 2), and continues with the development of newer cephalosporins and carbapenems for antibioticresistant infections. These agents act by inhibiting bacterial cell wall synthesis, as a result of their strong covalent binding to essential penicillin binding proteins (PBPs) that catalyze the last steps of cell wall formation in both Gram-positive and Gram-negative bacteria (3, 4). However, resistance to these agents has been a major concern to all who use, or have used, βlactams therapeutically.
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Bush, K. (2009). The Importance of β-Lactamases to the Development of New β-Lactams. In: Mayers, D.L. (eds) Antimicrobial Drug Resistance. Infectious Disease. Humana Press. https://doi.org/10.1007/978-1-59745-180-2_12
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