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The Structure of the Y Chromosome and Its Role in Male Infertility

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The Genetics of Male Infertility

Abstract

Male infertility accounts for a significant proportion of reproductive failure. Although ejaculatory disorders and impotence can be successfully treated with medical therapy, disorders of genetic origin are more difficult to successfully overcome. Recent advances in our knowledge of Y chromosome structure and function have provided insight into many aspects of the genetic basis of spermatogenic failure and its possible inheritance when assisted reproductive technologies are used to produce offspring.

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References

  1. Speroff L, Glass R, Kase N. Female infertility. In: Clinical Gynecologic Endocriniology and Infertility, 6th ed. Lippincott Williams & Wilkins, Hagerstown, MD 1999;1020–1021.

    Google Scholar 

  2. Razvi K, Chew S, Yong EL, Kumar J, Ng SC. The clinical management of male infertility. Singapore Med J 1999;4:291–297.

    Google Scholar 

  3. Rehman K, Grunbam A, Carrier S. Evaluation and treatment of oligoathenospermia in the era of assisted reproductive techniques. J Sex Reprod Med 2002;2:1–5.

    Google Scholar 

  4. Templeton A. Infertility—epidemiology, aetiology and effective management. Health Bulletin (Edinb) 1995;53:294–298.

    CAS  Google Scholar 

  5. Reijo R, Alagappan RK, Patrizio P, Page DC. Severe oligozoospermia resulting from deletions of azoospermia factor gene on Y chromosome. Lancet 1996;347:1290–1293.

    Article  PubMed  CAS  Google Scholar 

  6. Girardi SK, Mielnik A, Schlegel PN. Submicroscopic deletions in the Y chromosome of infertile men. Hum Reprod 1997;8:1635–1641.

    Article  Google Scholar 

  7. Tiepolo L, Zuffardi O. Localization of factors controlling spermatogenesis in the nonfluorescent portion of the human chromosome long arm. Hum Genet 1976;34:119–124.

    Article  PubMed  CAS  Google Scholar 

  8. Vollrath D, Foote S, Hilton A, et al. The human Y chromosome: a 43-interval map based on naturally occurring deletions. Science 1992;258:52–59.

    Article  PubMed  CAS  Google Scholar 

  9. Santos FR, Pandya A, Kayser M, et al. A polymorphic L1 retroposon insertion in the centromere of the human Y chromosome. Human Mol Genet 2000;9:421–430.

    Article  CAS  Google Scholar 

  10. Mathias H, Bayes M, Tyler-Smith C. Highly informative compound haplotypes for the human Y chromosome. Human Mol Genet 1994;1:115–123.

    Article  Google Scholar 

  11. Ali S, Hasnain SE. Molecular dissection of the human Y-chromosome. Gene 2002;283:1–10.

    Article  PubMed  CAS  Google Scholar 

  12. Vogt PH, Edelmann A, Kirsch S, Hengariu O, Hirschmann P, Kiesewater F. Human Y chromosome azoospermia factors (AZF) mapped to different subregions in YQ11. Hum Mol Genet 1996;5:933–943.

    Article  PubMed  CAS  Google Scholar 

  13. Repping S, Skaletsky H, Lange J, et al. Recombination between palindromes P5 and P1 on the human Y chromosome causes massive deletions and spermatogenic failure. Am J Human Genet 2002;71:906–922.

    Article  Google Scholar 

  14. Briton-Jones C, Haines CJ. Microdeletions on the long arm of the Y chromosome and their association with male-factor infertility. Hong Kong Med J 2000;6:184–189.

    PubMed  CAS  Google Scholar 

  15. Kuroda-Kawaguchi T, Skaletsky H, Brown LG, et al. The AZFc region of the Y chromosome features massive palindromes and uniform recurrent deletions in infertile men. Nat Genet 2001;29:279–286.

    Article  PubMed  CAS  Google Scholar 

  16. Saxena R, de Vries JW, Repping S, et al. Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome. Genomics 2000;67:256–267.

    Article  PubMed  CAS  Google Scholar 

  17. Behlke MA, Bogan JS, Beer-Romero P, Page DC. Evidence that the SRY protein is encoded by a single exon on the human Y chromosome. Genomics 1993;17:736–739.

    Article  PubMed  CAS  Google Scholar 

  18. Sinclair AH, Berta P, Palmer MS, et al. A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif. Nature 1990;346:240–244.

    Article  PubMed  CAS  Google Scholar 

  19. Sutcliffe AG. Intracytoplasmic sperm injection and other aspects of new reproductive technologies. Arch Dis Child 2000;83:98–101.

    Article  PubMed  CAS  Google Scholar 

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© 2007 Humana Press Inc.

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Ayensu-Coker, L., Bishop, C., Rohozinski, J. (2007). The Structure of the Y Chromosome and Its Role in Male Infertility. In: Carrell, D.T. (eds) The Genetics of Male Infertility. Humana Press. https://doi.org/10.1007/978-1-59745-176-5_14

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