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Genetic Determinants of Diabetic Nephropathy in Type 2 Diabetes

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The Diabetic Kidney

Part of the book series: Contemporary Diabetes ((CDI))

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Abstract

Diabetic nephropathy (DN) contributes significantly to morbidity and premature mortality in diabetes mellitus (1,2). Whereas the identification of specific environmental factors involved in the development of proteinuria and progressively declining kidney function have led to clinical measures that modify the natural history of the disease (3,4), available interventions (primarily blood glucose control and treatment with renoprotective and antihypertensive drugs) fall short of the ultimate goal of eradicating this complication. The severity of this deficiency is highlighted best by the fact that an epidemic of end-stage renal disease (ESRD) has developed over the past 20 yr, particularly in patients with type 2 diabetes mellitus (T2DM) in the United States, without any signs of leveling off (5). With T2DM becoming more common among young adults and in pediatric populations (6), one may infer that the burden of ESRD in the US population will increase even further unless more effective clinical measures are found.

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Authors and Affiliations

  1. Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA

    Grzegorz Placha MD, PhD

  2. Department of Internal Medicine and Hypertension, The Medical University of Warsaw, Warsaw, Poland

    Grzegorz Placha MD, PhD

  3. Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA

    Andrzej S. Krolewski MD, PhD

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  1. Grzegorz Placha MD, PhD
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Editors and Affiliations

  1. Division of Nephrology and Hypertension, Department of Medicine, Henry Ford Hospital, Detroit, MI

    Pedro Cortes MD

  2. Department of Internal Medicine M (Diabetes and Endocrinology), Aarhus University Hospital, Aarhus, Denmark

    Carl Erik Mogensen MD

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© 2006 Humana Press Inc., Totowa, NJ

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Placha, G., Krolewski, A.S. (2006). Genetic Determinants of Diabetic Nephropathy in Type 2 Diabetes. In: Cortes, P., Mogensen, C.E. (eds) The Diabetic Kidney. Contemporary Diabetes. Humana Press. https://doi.org/10.1007/978-1-59745-153-6_19

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  • DOI: https://doi.org/10.1007/978-1-59745-153-6_19

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-624-5

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