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Gene Expression Profiling in the Investigation of Diabetic Nephropathy

  • Katalin Susztak
  • Erwin Bottinger
  • Kumar Sharma
Part of the Contemporary Diabetes book series (CDI)

Abstract

Diabetic nephropathy (DN) develops in about one-third of patients with diabetes, with genetic and environmental factors both contributing to the development of the disease. Clinical studies have established that hypertension, poor glycemic and lipid control, and smoking (1) increase the risk of the development of the disease. It is clear however, that environmental factors alone are not sufficient for the development of this complication (2). In contrast, the prevalence of diabetic retinopathy continues to rise with the duration of diabetes in most populations. Family studies among type 1 diabetics have shown that if one sibling develops nephropathy, the other sibling has a fourfold increased risk of developing it (3). These observations have clearly established the importance of genetic risk factors in the development of DN. It is likely that the genetic response to hyperglycemia varies among individuals and patients who develop a pattern of excessive regulation of nephropathy-related genes will be the ones at greatest risk of developing^DN.

Keywords

Gene Expression Profile Diabetic Nephropathy Bacterial Artificial Chromosome Diabetic Mouse Laser Capture Microdissection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Humana Press Inc., Totowa, NJ 2006

Authors and Affiliations

  • Katalin Susztak
    • 1
  • Erwin Bottinger
    • 2
  • Kumar Sharma
    • 3
  1. 1.Division of Nephrology, Department of Medicine, Mount Sinai School of MedicineDorrace Hamilton Research LaboratoriesNew York
  2. 2.Division of Nephrology, Department of MedicineAlbert Einstein College of MedicineBronx
  3. 3.Center for Diabetic Kidney Disease, Dorrance Hamilton Research Laboratories and Division of NephrologyDepartment of Medicine, Jefferson UniversityPhiladelphia

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