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Hepatocyte Growth Factor

Physiological and Therapeutic Ligand to Attenuate Diabetic Nephropathy

  • Chapter
The Diabetic Kidney

Part of the book series: Contemporary Diabetes ((CDI))

Abstract

Chronic renal disease (CRD) has been considered to be irreversible (1). Renal fibrosis, a histological diagnosis of end-stage CRD, is characterized by a loss of renal parenchymal cells that are replaced by extracellular matrix (ECM) proteins, a common final pathway leading to renal dysfunction (1,2). The number of patients affected with CRD is on the increase, and dialysis market estimates indicate that more than 1 million patients worldwide have undergone maintenance dialysis. Thus, many nations are burdened with social and financial problems associated with funding health services for the dialysis of CRD patients (3). Diabetes is now the leading cause of end-stage renal disease (ESRD) in many developed countries, and diabetic nephropathy (DN) has emerged as a silent epidemic worldwide (2,3). This is certainly the case in Japan, in which diabetic kidney disease accounted for 35% of all new patients undergoing dialysis in 2003. To maintain replacement therapy, it now costs nearly $10 million per year in Japan for public financial support. Likewise, in the United States, DN accounted for 35% of all new cases of ESRD in 1997. The physical and monetary costs of diabetic kidney disease to both the patient and society are now enormous.

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Authors and Affiliations

  1. Division of Molecular Regenerative Medicine, Department of Molecular Regenerative Medicine, Osaka University Graduate School of Medicine, Suita Osaka, Japan

    Shinya Mizuno PhD & Toshikazu Nakamura PhD

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  1. Shinya Mizuno PhD
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  2. Toshikazu Nakamura PhD
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Editors and Affiliations

  1. Division of Nephrology and Hypertension, Department of Medicine, Henry Ford Hospital, Detroit, MI

    Pedro Cortes MD

  2. Department of Internal Medicine M (Diabetes and Endocrinology), Aarhus University Hospital, Aarhus, Denmark

    Carl Erik Mogensen MD

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© 2006 Humana Press Inc., Totowa, NJ

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Mizuno, S., Nakamura, T. (2006). Hepatocyte Growth Factor. In: Cortes, P., Mogensen, C.E. (eds) The Diabetic Kidney. Contemporary Diabetes. Humana Press. https://doi.org/10.1007/978-1-59745-153-6_13

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  • DOI: https://doi.org/10.1007/978-1-59745-153-6_13

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-624-5

  • Online ISBN: 978-1-59745-153-6

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