Hepatocyte Growth Factor

Physiological and Therapeutic Ligand to Attenuate Diabetic Nephropathy
  • Shinya Mizuno
  • Toshikazu Nakamura
Part of the Contemporary Diabetes book series (CDI)


Chronic renal disease (CRD) has been considered to be irreversible (1). Renal fibrosis, a histological diagnosis of end-stage CRD, is characterized by a loss of renal parenchymal cells that are replaced by extracellular matrix (ECM) proteins, a common final pathway leading to renal dysfunction (1,2). The number of patients affected with CRD is on the increase, and dialysis market estimates indicate that more than 1 million patients worldwide have undergone maintenance dialysis. Thus, many nations are burdened with social and financial problems associated with funding health services for the dialysis of CRD patients (3). Diabetes is now the leading cause of end-stage renal disease (ESRD) in many developed countries, and diabetic nephropathy (DN) has emerged as a silent epidemic worldwide (2,3). This is certainly the case in Japan, in which diabetic kidney disease accounted for 35% of all new patients undergoing dialysis in 2003. To maintain replacement therapy, it now costs nearly $10 million per year in Japan for public financial support. Likewise, in the United States, DN accounted for 35% of all new cases of ESRD in 1997. The physical and monetary costs of diabetic kidney disease to both the patient and society are now enormous.


Diabetic Nephropathy Hepatocyte Growth Factor Connective Tissue Growth Factor Renal Fibrosis Diabetic Kidney Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Humana Press Inc., Totowa, NJ 2006

Authors and Affiliations

  • Shinya Mizuno
    • 1
  • Toshikazu Nakamura
    • 1
  1. 1.Division of Molecular Regenerative Medicine, Department of Molecular Regenerative MedicineOsaka University Graduate School of MedicineSuita OsakaJapan

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