Vascular Endothelial Growth Factor as a Determinant of Diabetic Nephropathy

  • Geoffrey Boner
  • Mark E. Cooper
Part of the Contemporary Diabetes book series (CDI)


Diabetic nephropathy is the major cause of end-stage renal disease in the United States and in many other countries (1, 2, 3). The development of diabetic nephropathy is thought to occur as a result of an interplay between hemodynamic and metabolic factors (4,5). The various metabolic factors, such as the renal accumulation of advanced glycation end (AGE) products and activation of the polyol pathway, as well as hemodynamic changes, including changes in vasoactive hormones such as the renin-angiotensin system (RAS), act through the stimulation of various intracellular second messengers, cytokines and growth factors to induce end-organ injury (5,6). Vascular endothelial growth factor (VEGF), originally known as vascular permeability factor because of its ability to stimulate vascular permeability, was later shown to have a mitogenic effect in endothelial cells (7,8). Indeed, VEGF was shown to stimulate angiogenesis (8) and has subsequently been postulated to play a role in the pathogenesis of various complications of diabetes (9). In this chapter, we will discuss the role of VEGF, as yet not fully delineated in the development of diabetic nephropathy.


Vascular Endothelial Growth Factor Diabetic Nephropathy Vascular Endothelial Growth Factor Expression Vascular Endothelial Growth Factor Level Vascular Endothelial Growth Factor mRNA 
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Copyright information

© Humana Press Inc., Totowa, NJ 2006

Authors and Affiliations

  • Geoffrey Boner
    • 1
    • 2
  • Mark E. Cooper
    • 2
  1. 1.Department of Internal MedicineSackler Faculty of Medicine, Tel Aviv UniversityTel AvivIsrael
  2. 2.Danielle Alberti Memorial Centre for Diabetes Complications, Vascular Division, Wynn DomainBaker Medical Research InstituteMelbourneAustralia

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