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Vascular Endothelial Growth Factor as a Determinant of Diabetic Nephropathy

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The Diabetic Kidney

Part of the book series: Contemporary Diabetes ((CDI))

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Abstract

Diabetic nephropathy is the major cause of end-stage renal disease in the United States and in many other countries (1–3). The development of diabetic nephropathy is thought to occur as a result of an interplay between hemodynamic and metabolic factors (4,5). The various metabolic factors, such as the renal accumulation of advanced glycation end (AGE) products and activation of the polyol pathway, as well as hemodynamic changes, including changes in vasoactive hormones such as the renin-angiotensin system (RAS), act through the stimulation of various intracellular second messengers, cytokines and growth factors to induce end-organ injury (5,6). Vascular endothelial growth factor (VEGF), originally known as vascular permeability factor because of its ability to stimulate vascular permeability, was later shown to have a mitogenic effect in endothelial cells (7,8). Indeed, VEGF was shown to stimulate angiogenesis (8) and has subsequently been postulated to play a role in the pathogenesis of various complications of diabetes (9). In this chapter, we will discuss the role of VEGF, as yet not fully delineated in the development of diabetic nephropathy.

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Authors and Affiliations

  1. Department of Internal Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Geoffrey Boner MBBCh

  2. Danielle Alberti Memorial Centre for Diabetes Complications, Vascular Division, Wynn Domain, Baker Medical Research Institute, Melbourne, Australia

    Geoffrey Boner MBBCh & Mark E. Cooper MD

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  1. Geoffrey Boner MBBCh
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  2. Mark E. Cooper MD
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Editors and Affiliations

  1. Division of Nephrology and Hypertension, Department of Medicine, Henry Ford Hospital, Detroit, MI

    Pedro Cortes MD

  2. Department of Internal Medicine M (Diabetes and Endocrinology), Aarhus University Hospital, Aarhus, Denmark

    Carl Erik Mogensen MD

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© 2006 Humana Press Inc., Totowa, NJ

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Boner, G., Cooper, M.E. (2006). Vascular Endothelial Growth Factor as a Determinant of Diabetic Nephropathy. In: Cortes, P., Mogensen, C.E. (eds) The Diabetic Kidney. Contemporary Diabetes. Humana Press. https://doi.org/10.1007/978-1-59745-153-6_11

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  • DOI: https://doi.org/10.1007/978-1-59745-153-6_11

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-624-5

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