Abstract
The complete nucleotide sequences of three and, in the not too distant future, six strains from the genus Leptospira will be available. Managing and maintaining these data will be a perpetual problem unless a system is devised to address this issue. We propose a central role for the International Union of Microbiological Societies Subcommittee on the Taxonomy of Leptospira in maintaining and updating the annotated leptospiral genome sequences. The first step in this process is provided as part of this publication, namely a revision of the annotation of the three published genomes, and an internet location for the current versions of these genomes.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Chappel, R. J., Goris, M., Palmer, M. F., and Hartskeerl, R. A. (2004) Impact of proficiency testing on results of the microscopic agglutination test for diagnosis of leptospirosis. J. Clin. Microbiol. 42, 5484–5488.
Perolat, P., Chappel, R. J., Adler, B., et al. (1998) Leptospira fainei sp. nov., isolated from pigs in Australia. Int. J. Syst. Bacteriol. 48, 851–858.
Faine, S., Adler, B., Bolin, C., and Perolat, P. (1999) tLeptospira and Leptospirosis. 2nd ed. MediSci, Melbourne, Australia.
Ren, S. X., Fu, G., Jiang, X. G., et al. (2003) Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing. Nature 422, 888–893.
Nascimento, A. L., Ko, A. I., Martins, E. A., et al. (2004) Comparative genomics of two Leptospira interrogans serovars reveals novel insights into physiology and pathogenesis. J. Bacteriol. 186, 2164–2172.
Fraser, C. M., Norris, S. J., Weinstock, G. M., et al. (1998) Complete genome sequence of Treponema pallidum, the syphilis spirochete. Science 281, 375–388.
Seshadri, R., Myers, G. S., Tettelin, H., et al. (2004) Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes. Proc. Natl. Acad. Sci. USA 101, 5646–5651.
Fraser, C. M., Casjens, S., Huang, W. M., et al. (1997) Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi. Nature 390, 580–586.
Ussery, D. W. and Hallin, P. F. (2004) Genome update: annotation quality in sequenced microbial genomes. Microbiology 150, 2015–2017.
Glockner, G., Lehmann, R., Romualdi, A., et al. (2004) Comparative analysis of the Borrelia garinii genome. Nucleic Acids Res. 32, 6038–6046.
Ralph, D. and McClelland, M. (1993) Intervening sequence with conserved open reading frame in eubacterial 23S rRNA genes. Proc. Natl. Acad. Sci. USA 90, 6864–6868.
Que-Gewirth, N. L., Ribeiro, A. A., Kalb, S. R., et al. (2004) A methylated phosphate group and four amide-linked acyl chains in Leptospira interrogans Lipid A. The membrane anchor of an unusual lipopolysaccharide that activates TLR2. J. Biol. Chem. 279, 25,420–25,429.
Besemer, J., Lomsadze, A., and Borodovsky, M. (2001) GeneMarkS: a self-training method for prediction of gene starts in microbial genomes. Implications for finding sequence motifs in regulatory regions. Nucleic Acids Res. 29, 2607–2618.
Tatusov, R. L., Fedorova, N. D., Jackson, J. D., et al. (2003) The COG database: an updated version includes eukaryotes. BMC Bioinformatics 4, 41.
Paget, M. S. and Helmann, J. D. (2003) The sigma-70 family of sigma factors. Genome Biol. 4, 203.
Helmann, J. D. (2002) The extracytoplasmic function (ECF) sigma factors. Adv. Microb. Physiol. 46, 47–110.
Galperin, M. Y., Nikolskaya, A. N., and Koonin, E. V. (2001) Novel domains of the prokaryotic two-component signal transduction systems. FEMS Microbiol. Lett. 203, 11–21.
Ballard, S. A., Go, M., Segers, R. P., and Adler, B. (1998) Molecular analysis of the dnaK locus of Leptospira interrogans serovar Copenhageni. Gene 216, 21–29.
Nakatogawa, H., Murakami, A., and Ito, K. (2004) Control of SecA and SecM translation by protein secretion. Curr. Opinion. Microbiol. 7, 145–150.
Haake, D. A. (2000) Spirochaetal lipoproteins and pathogenesis. Microbiology 146, 14911504.
Mangels, D., Mathers, J., Bolhuis, A., and Robinson, C. (2005) The core TatABC complex of the twin-arginine translocase in Escherichia coli: TatC drives assembly whereas TatA is essential for stability. J. Mol. Biol. 345, 415–423.
Matsunaga, J., Barocchi, M. A., Croda, J., et al. (2003) Pathogenic Leptospira species express surface-exposed proteins belonging to the bacterial immunoglobulin superfamily. Mol. Microbiol. 49, 929–945.
Juncker, A. S., Willenbrock, H., Von Heijne, G., Brunak, S., Nielsen, H., and Krogh, A. (2003) Prediction of lipoprotein signal peptides in Gram-negative bacteria. Prot. Sci. 12, 1652–1662.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 Humana Press Inc., Totowa, NJ
About this chapter
Cite this chapter
Bulach, D.M., Seemann, T., Zuerner, R.L., Adler, B. (2006). The Organization of Leptospira at a Genomic Level. In: Chan, V.L., Sherman, P.M., Bourke, B. (eds) Bacterial Genomes and Infectious Diseases. Humana Press. https://doi.org/10.1007/978-1-59745-152-9_7
Download citation
DOI: https://doi.org/10.1007/978-1-59745-152-9_7
Publisher Name: Humana Press
Print ISBN: 978-1-58829-496-8
Online ISBN: 978-1-59745-152-9
eBook Packages: MedicineMedicine (R0)