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Troxacitabine (Troxatyl ™)

A Deoxycytidine Nucleoside Analog With Potent Antitumor Activity

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Deoxynucleoside Analogs In Cancer Therapy

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

Nucleoside analogs are commonly used in the treatment of hematological malignancies and solid tumors. As antimetabolites, these drugs act by disrupting DNA synthesis and inducing apoptosis following their incorporation into DNA. Troxacitabine (Troxatyl™ Shire Biochem, Inc., exclusively licensed to SGX Pharmaceuticals, Inc.) is the first nucleoside analog with anticancer activity that has an unnatural stereochemical configuration. Its broad preclinical antineoplastic spectrum led to its clinical development. Summaries of the preclinical data and of the initial phase I and II clinical trials are presented.

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Author information

Authors and Affiliations

  1. Pharmacology/Toxicology, Ecopia BioSciences Inc., Ville Saint-Laurent, Québec, Canada

    Henriette Gourdeau PhD (Associate Director)

  2. Aegera Therapeutics Inc., Montreal, Québec, Canada

    Jacques Jolivet MD (Vice-President of Clinical Development)

Authors
  1. Henriette Gourdeau PhD
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  2. Jacques Jolivet MD
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Editors and Affiliations

  1. VU University Medical Center Amsterdam, The Netherlands

    Godefridus J. Peters PhD (Professor of Medical Oncology) (Professor of Medical Oncology)

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© 2006 Humana Press Inc., Totowa, NJ

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Gourdeau, H., Jolivet, J. (2006). Troxacitabine (Troxatyl ™). In: Peters, G.J. (eds) Deoxynucleoside Analogs In Cancer Therapy. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-59745-148-2_9

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