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Clofarabine

Mechanisms of Action, Pharmacology, and Clinical Investigations

  • Chapter
Deoxynucleoside Analogs In Cancer Therapy

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

Clofarabine is a new dAdo analog that shows effectiveness in both adult and pediatric ALL and AML. The pharmacokinetic and pharmacodynamic profile of the drug in acute leukemias is favorable relative to fludarabine or cladribine and may have prognostic value for its clinical activity. The toxicity profile of this agent is different from other nucleoside analogs in that it clearly has clinical activity when used as a single agent against adult acute leukemias at tolerable doses. Further, therapeutic strategies combining clofarabine with DNA-damaging agents are likely to allow mechanismbased rationales to be evaluated with minimal likelihood of untoward toxicity. Exploration of additional schedules and combinations along with availability of an oral formulation strongly indicate promising possibilities with this agent.

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Authors and Affiliations

  1. Department of Experimental Therapeutics, The University of Texas, M. D., Anderson Cancer Center, Houston, TX, USA

    Varsha Gandhi PhD & William Plunkett PhD

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  1. Varsha Gandhi PhD
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  2. William Plunkett PhD
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Editors and Affiliations

  1. VU University Medical Center Amsterdam, The Netherlands

    Godefridus J. Peters PhD (Professor of Medical Oncology) (Professor of Medical Oncology)

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© 2006 Humana Press Inc., Totowa, NJ

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Gandhi, V., Plunkett, W. (2006). Clofarabine. In: Peters, G.J. (eds) Deoxynucleoside Analogs In Cancer Therapy. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-59745-148-2_7

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