Abstract
Polyamines are essential polycations involved in a large variety of biological functions, including modulation of the nucleic acid conformation, RNA export and their degradation, protein synthesis, eIF-5A posttranslational modification, signal transduction, cell growth and differentiation, and tumor progression ( 1 –bi3. These various aspects in the biology of polyamines are addressed in other sections of this book.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Tabor, C.W. and Tabor, H. (1984) Polyamines. Annu. Rev. Biochem. 53, 749–790.
Pegg, A. E., Secrist, J.A., 3rd, and Madhubala, R. (1988) Properties of L1210 cells resistant to alpha-difluoromethylornithine. Cancer Res. 48, 2678–2682.
Fozard, J. R., Part, M. L., Prakash, N. J., et al. (1980) L-Ornithine decarboxylase: An essential role in early mammalian embryogenesis. Science 208, 505–508.
Bianchi, L., Roy, M. L., Taglialatela, M., Lundgren, D. W., Brown, A. M., and Ficker, E. (1996) Regulation by spermine of native inward rectifier Kgg channels in RBL-1 cells. J. Biol. Chem. 271, 6114–6121.
Johnson, T. D. (1996) Modulation of channel function by polyamines. Trends Pharmacol. Sci. 17, 22–27.
Williams, K. (1997) Interactions of polyamines with ion channels. B i o chem. J. 325, 289–297.
Kashiwagi, K., Pahk, A. J., Masuko, T., Igarashi, K., and Williams, K. (1997) Block and modulation of N-methyl-D-aspartate receptors by polyamines and protons: Role of amino acid residues in the transmembrane and pore-forming regions of NR1 and NR2 subunits. Mol. Pharmacol. 52, 701–713.
Williams, K. (1997) Interactions of polyamines with ion channels. B i o chem. J. 325, 289–297.
Williams, K. (1997) Modulation and block of ion channels: a new biology of polyamines. Cell Signal 9, 1–13.
Kamboj, S. K., Swanson, G. T., and Cull-Candy, S. G. (1995) Intracellular spermine confers rectification on rat calcium-permeable A M PA and kainate receptors. J. Physiol. 486, 297–303.
Fakler, B., Brandle, U., Bond, C., et al. (1994) A structural determinant of differential sensitivity of cloned inward rectifier K?? channels to intracellular spermine. FEBS Lett. 356, 199–203.
Ficker, E., Taglialatela, M., Wible, B. A., Henley, C. M., and Brown, A. M. (1994) Spermine and spermidine as gating molecules for inward rectifier K?? channels. Science 266, 1068–1072.
Lopatin, A. N., Makhina, E. N., and Nichols, C. G. (1994) Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification. Nature 372, 366–369.
Lu, Z. and Ding, L. (1999) Blockade of a retinal cGMP-gated channel by polyamines. J. Gen. Physiol. 113, 35–43.
Haghighi, A. P. and Cooper, E. (1998) Neuronal nicotinic acetylcholine receptors are blocked by intracellular spermine in a voltage-dependent manner. J. Neurosci. 18, 4050–4062.
Haghighi, A. P. and Cooper, E. (2000) A molecular link between inward rectification and calcium permeability of neuronal nicotinic acetylcholine alpha3beta4 and alpha4beta2 receptors. J. Neurosci. 20, 529–541.
Huang, C. J. and Moczydlowski, E. (2001) Cytoplasmic polyamines as permeant blockers and modulators of the voltage-gated sodium channel. Biophys. J. 80, 1262–1279.
Scott, R. H., Sutton, K. G., and Dolphin, A. C. (1993) Interactions of polyamines with neuronal ion channels. Trends Neurosci. 16, 153–160.
Choi, D. W. (1988) Glutamate neurotoxicity and diseases of the nervous system. Neuron 1, 623–634.
Lipton, S. A. and Rosenberg, P. A. (1994) Excitatory amino acids as a final common pathway for neurologic disorders. N. Engl. J. Med. 330, 613–622.
Schinder, A. F., Olson, E. C., Spitzer, N. C., and Montal, M. (1996) Mitochondrial dysfunction is a primary event in glutamate neurotoxicity. J. Neurosci. 16, 6125–6133.
White, R. J. and Reynolds, I. J. (1996) Mitochondrial depolarization in glutamate-stimulated neurons: an early signal specific to excitotoxin exposure. J. Neurosci. 16, 5688–5697.
Beatrice, M. C., Palmer, J. W., and Pfeiffer, D. R. (1980) The relationship between mitochondrial membrane permeability, membrane potential, and the retention of Ca2?? by mitochondria. J. Biol. Chem. 255, 8663–8671.
Gunter, T. E. and Pfeiffer, D. R. (1990) Mechanisms by which mitochondria transport calcium. Am. J. Physiol. 258, C755–C786.
Coyle, J. T. and Puttfarcken, P. (1993) Oxidative stress, glutamate, and neurodegenerative disorders. Science 262, 689–695.
Kirby, B. P. and Shaw, G. G. (2004) The neuroprotective effects of N1-dansyl-spermine in the gerbil model of cerebral ischaemia. Brain Res. 1011, 74–83.
Morrison, L. D., Cao, X. C., and Kish, S. J. (1998) Ornithine decarboxylase in human brain: Influence of aging, regional distribution, and Alzheimer’s disease. J. Neurochem. 71, 288–294.
Gilad, G. M. and Gilad, V. H. (1983) Polyamine biosynthesis is required for survival of sympathetic neurons after axonal injury. Brain Res. 273, 191–194.
Porcella, A., Carter, C., Fage, D., et al. (1991) The effects of N-methyl-D-aspartate and kainate lesions of the rat striatum on striatal ornithine decarboxylase activity and polyamine levels. Brain Res. 549, 205–212.
Gilad, G. M. and Gilad, V. H. (1988) Early polyamine treatment enhances survival of sympathetic neurons after postnatal axonal injury or immunosympathectomy. B rain Res. 466, 175–181.
Ha, H. C., Sirisoma, N. S., Kuppusamy, P., Zweier, J. L., Woster, P. M., and Casero, R. A., Jr. (1998) The natural polyamine spermine functions directly as a free radical scavenger. Proc. Natl. Acad. Sci. USA 95, 11,140–11,145.
Shimizu, H., Kakimoto, Y., and Sano, I. (1965) Changes in concentration of polyamines in the developing mouse brain. Nature 207, 1196–1197.
Cai, D., Deng, K., Mellado, W., Lee, J., Ratan, R., and Filbin, M. (2002) A rginase I and polyamines act downstream from cyclic A M P in overcoming inhibition of axonal growth MAG and myelin in vitro. Neuron 35, 711.
Clarke, J. R. and Tyms, A. S. (1991) Polyamine biosynthesis in cells infected with different clinical isolates of human cytomegalovirus. J. Med. Virol. 34, 212–216.
Seiler, N. (2000) Oxidation of polyamines and brain injury. Neurochem. Res. 25, 471–490.
Lee, S. J. and Lee, S. (2002) Toll-like receptors and inflammation in the CNS. Curr. Drug Targets Inflamm. Allergy 1, 181–191.
Wright, S. D. (1999) Toll, a new piece in the puzzle of innate immunity. J. Exp. Med. 189, 605–609.
Taveira da Silva, A. M., Kaulbach, H. C., Chuidian, F. S., Lambert, D. R., Suffredini, A. F., and Danner, R. L. (1993) Brief report: shock and multiple-organ dysfunction after selfadministration of Salmonella endotoxin. N. Engl. J. Med. 328, 1457–1460.
Nguyen, M. D., Julien, J. P. and Rivest, S. (2002) Innate immunity: the missing link in neuroprotection and neurodegeneration? Nat. Rev. Neurosci. 3, 216–227.
Hasko, G., Kuhel, D. G., Marton, A., Nemeth, Z. H., Deitch, E. A., and Szabo, C. (2000) Spermine differentially regulates the production of interleukin-12 p40 and interleukin-10 and suppresses the release of the T helper 1 cytokine interferon-gamma. Shock 14, 144–149.
Messina, L., Arcidiacono, A., Spampinato, G., et al. (1990) Accumulation of ornithine decarboxylase mRNA accompanies activation of human and mouse monocytes/ macrophages. FEBS Lett. 268, 32–34.
Byrd, W. J., Jacobs, D. M., and Amoss, M. S. (1977) Synthetic polyamines added to cultures containing bovine sera reversibly inhibit in vitro parameters of immunity. Nature 267, 621–623.
Ferrante, A., Maxwell, G. M., Rencis, V. O., Allison, A. C., and Morgan, D. M. (1986) Inhibition of the respiratory burst of human neutrophils by the polyamine oxidasepolyamine system. Int. J. Immunopharmacol. 8, 411–417.
Quemener, V., Blanchard, Y., Chamaillard, L., Havouis, R., Cipolla, B., and Moulinoux, J. P. (1994) Polyamine deprivation: A new tool in cancer treatment. Anticancer Res. 14, 443–448.
Zheng, S. A., McElwain, C. M., and Taffet, S. M. (1991) Regulation of mouse ornithine decarboxylase gene expression in a macrophage-like cell line: synergistic induction by bacterial lipopolysaccharide and cAMP. Biochem. Biophys. Res. Commun. 175, 48–54.
Szabo, C., Southan, G. J., Wood, E., Thiemermann, C., and Vane, J. R. (1994) Inhibition by spermine of the induction of nitric oxide synthase in J774.2 macrophages: Requirement of a serum factor. Br. J. Pharmacol. 112, 355–356.
Molitor, J., Pace, W., Stunz, L., Vigna, J., Louie, S., and Ashman, R. (1994) Induction of ornithine decarboxylase activity in mouse B lymphocytes. Int. Immunol. 6, 1777–1784.
Tjandrawinata, R. R., Hawel, 3rd, L., and Byus, C. V. (1994) Regulation of putrescine export in lipopolysaccharide or IFN-gamma-activated murine monocytic-leukemic RAW 264 cells. J. Immunol. 152, 3039–3052.
Zhang, M., Borovikova, L. V., Wang, H., Metz, C., and Tracey, K. J. (1999) Spermine inhibition of monocyte activation and inflammation. Mol. Med. 5, 595–605.
Sugimoto, H., Matsuzaki, Y., Yuasa, K., et al. (1992) Estradiol-17 beta modifies the induction of spermidine/spermine N1-acetyltransferase activity in the liver of lipopolysaccharide-treated mice. Liver 12, 147–151.
Zhang, M., Wang, H., and Tracey, K. J. (2000) Regulation of macrophage activation and inflammation by spermine: A new chapter in an old story. Crit. Care Med. 28, N60–N66.
Southan, G. J., Szabo, C., and Thiemermann, C. (1994) Inhibition of the induction of nitric oxide synthase by spermine is modulated by aldehyde dehydrogenase. B i o chem. Biophys. Res. Commun. 203, 1638–1644.
Szabo, C., Southan, G. J., Thiemermann, C., and Vane, J. R. (1994) The mechanism of the inhibitory effect of polyamines on the induction of nitric oxide synthase: role of aldehyde metabolites. Br. J. Pharmacol. 113, 757–766.
Bauer, P. M., Buga, G. M., Fukuto, J. M., Pegg, A. E., and Ignarro, L. J. (2001) Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme. J. Biol. Chem. 276, 34,458–34,464.
Ignarro, L.J., Buga, G. M., Wei, L. H., Bauer, P. M., Wu, G., and del Soldato, P. (2001) Role of the arginine-nitric oxide pathway in the regulation of vascular smooth muscle cell proliferation. Proc. Natl. Acad. Sci. USA 98, 4202–4208.
Nadeau, S. and Rivest, S. (2000) Role of microglial-derived tumor necrosis factor in mediating CD14 transcription and nuclear factor kappa B activity in the brain during endotoxemia. J. Neurosci. 20, 3456–3468.
Nadeau, S. and Rivest, S. (2001) The complement system is an integrated part of the natural innate immune response in the brain. FASEB J. 15, 1410–1412.
Laflamme, N., Soucy, G., and Rivest, S. (2001) Circulating cell wall components derived from gram-negative, not gram-positive, bacteria cause a profound induction of the geneencoding Toll-like receptor 2 in the CNS. J. Neurochem. 79, 648–657.
Laflamme, N. and Rivest, S. (2001) Toll-like receptor 4: the missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components. FASEB J. 15, 155–163.
Kilpelainen, P., Rybnikova, E., Hietala, O., and Pelto-Huikko, M. (2000) Expression of ODC and its regulatory protein antizyme in the adult rat brain. J. Neurosci. Res. 62, 675–685.
Soulet, D. and Rivest, S. (2003) Polyamines play a critical role in the control of the innate immune response in the mouse central nervous system. J. Cell. Biol. 162, 257–268.
Gottlieb, M. and Matute, C. (1997) Expression of ionotropic glutamate receptor subunits in glial cells of the hippocampal CA1 area following transient forebrain ischemia. J. Cereb. Blood Flow Metab. 17, 290–300.
Kingham, P. J., Cuzner, M. L., and Pocock, J. M. (1999) Apoptotic pathways mobilized in microglia and neurones as a consequence of chromogranin A-induced microglial activation. J. Neurochem. 73, 538–547.
Oka, A., Belliveau, M. J., Rosenberg, P. A., and Volpe, J. J. (1993) Vulnerability of oligodendroglia to glutamate: pharmacology, mechanisms, and prevention. J. Neurosci. 13, 1441–1453.
Sanchez-Gomez, M. V. and Matute, C. (1999) AMPA and kainate receptors each mediate excitotoxicity in oligodendroglial cultures. Neurobiol. Dis. 6, 475–485.
Baimbridge, K. G., Celio, M. R., and Rogers, J. H. (1992) Calcium-binding proteins in the nervous system. Trends Neurosci. 15, 303–308.
Nguyen, M. D., Julien, J. P. and Rivest. S. (2002) Innate immunity: the missing link in neuroprotection and neurodegeneration? Nat. Rev. Neurosci. 3, 216–227.
McKay, L. I. and Cidlowski, J. A. (1999) Molecular control of immune/inflammatory responses: Interactions between nuclear factor-kappa B and steroid receptor-signaling pathways. Endocr. Rev. 20, 435–459.
Nadeau, S. and Rivest, S. (2002) Endotoxemia prevents the cerebral inflammatory wave induced by intraparenchymal lipopolysaccharide injection: Role of glucocorticoids and CD14. J. Immunol. 169, 3370–3381.
Nadeau, S. and Rivest, S. (2003) Glucocorticoids play a fundamental role in potecting the brain during innate immune response. J. Neurosci. 23, 5536–5544.
Zhang, M., Caragine, T., Wang, H., et al. (1997) Spermine inhibits proinflammatory cytokine synthesis in human mononuclear cells: A counterregulatory mechanism that restrains the immune response. J. Exp. Med. 185, 1759–1768.
Nomura, F., Akashi, S., Sakao, Y., et al. (2000) Cutting edge: Endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression. J. Immunol. 164, 3476–3479.
Gomes-Trolin, C., Nygren, I., Aquilonius, S. M., and Askmark, H. (2002) Increased red blood cell polyamines in ALS and Parkinson’s disease. Exp. Neurol. 177, 515–520.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 Humana Press Inc., Totowa, NJ
About this chapter
Cite this chapter
Soulet, D., Rivest, S. (2006). Role of Polyamines in the Control of the Immune Response in the Brain. In: Wang, JY., Casero, R.A. (eds) Polyamine Cell Signaling. Humana Press. https://doi.org/10.1007/978-1-59745-145-1_16
Download citation
DOI: https://doi.org/10.1007/978-1-59745-145-1_16
Publisher Name: Humana Press
Print ISBN: 978-1-58829-625-2
Online ISBN: 978-1-59745-145-1
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)