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Role of Polyamines in the Control of the Immune Response in the Brain

  • Chapter
Polyamine Cell Signaling

Abstract

Polyamines are essential polycations involved in a large variety of biological functions, including modulation of the nucleic acid conformation, RNA export and their degradation, protein synthesis, eIF-5A posttranslational modification, signal transduction, cell growth and differentiation, and tumor progression ( 1bi3. These various aspects in the biology of polyamines are addressed in other sections of this book.

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References

  1. Tabor, C.W. and Tabor, H. (1984) Polyamines. Annu. Rev. Biochem. 53, 749–790.

    Article  PubMed  CAS  Google Scholar 

  2. Pegg, A. E., Secrist, J.A., 3rd, and Madhubala, R. (1988) Properties of L1210 cells resistant to alpha-difluoromethylornithine. Cancer Res. 48, 2678–2682.

    PubMed  CAS  Google Scholar 

  3. Fozard, J. R., Part, M. L., Prakash, N. J., et al. (1980) L-Ornithine decarboxylase: An essential role in early mammalian embryogenesis. Science 208, 505–508.

    Article  PubMed  CAS  Google Scholar 

  4. Bianchi, L., Roy, M. L., Taglialatela, M., Lundgren, D. W., Brown, A. M., and Ficker, E. (1996) Regulation by spermine of native inward rectifier Kgg channels in RBL-1 cells. J. Biol. Chem. 271, 6114–6121.

    Article  PubMed  CAS  Google Scholar 

  5. Johnson, T. D. (1996) Modulation of channel function by polyamines. Trends Pharmacol. Sci. 17, 22–27.

    Article  PubMed  CAS  Google Scholar 

  6. Williams, K. (1997) Interactions of polyamines with ion channels. B i o chem. J. 325, 289–297.

    CAS  Google Scholar 

  7. Kashiwagi, K., Pahk, A. J., Masuko, T., Igarashi, K., and Williams, K. (1997) Block and modulation of N-methyl-D-aspartate receptors by polyamines and protons: Role of amino acid residues in the transmembrane and pore-forming regions of NR1 and NR2 subunits. Mol. Pharmacol. 52, 701–713.

    PubMed  CAS  Google Scholar 

  8. Williams, K. (1997) Interactions of polyamines with ion channels. B i o chem. J. 325, 289–297.

    CAS  Google Scholar 

  9. Williams, K. (1997) Modulation and block of ion channels: a new biology of polyamines. Cell Signal 9, 1–13.

    Article  PubMed  CAS  Google Scholar 

  10. Kamboj, S. K., Swanson, G. T., and Cull-Candy, S. G. (1995) Intracellular spermine confers rectification on rat calcium-permeable A M PA and kainate receptors. J. Physiol. 486, 297–303.

    PubMed  CAS  Google Scholar 

  11. Fakler, B., Brandle, U., Bond, C., et al. (1994) A structural determinant of differential sensitivity of cloned inward rectifier K?? channels to intracellular spermine. FEBS Lett. 356, 199–203.

    Article  PubMed  CAS  Google Scholar 

  12. Ficker, E., Taglialatela, M., Wible, B. A., Henley, C. M., and Brown, A. M. (1994) Spermine and spermidine as gating molecules for inward rectifier K?? channels. Science 266, 1068–1072.

    Article  PubMed  CAS  Google Scholar 

  13. Lopatin, A. N., Makhina, E. N., and Nichols, C. G. (1994) Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification. Nature 372, 366–369.

    Article  PubMed  CAS  Google Scholar 

  14. Lu, Z. and Ding, L. (1999) Blockade of a retinal cGMP-gated channel by polyamines. J. Gen. Physiol. 113, 35–43.

    Article  PubMed  CAS  Google Scholar 

  15. Haghighi, A. P. and Cooper, E. (1998) Neuronal nicotinic acetylcholine receptors are blocked by intracellular spermine in a voltage-dependent manner. J. Neurosci. 18, 4050–4062.

    PubMed  CAS  Google Scholar 

  16. Haghighi, A. P. and Cooper, E. (2000) A molecular link between inward rectification and calcium permeability of neuronal nicotinic acetylcholine alpha3beta4 and alpha4beta2 receptors. J. Neurosci. 20, 529–541.

    PubMed  CAS  Google Scholar 

  17. Huang, C. J. and Moczydlowski, E. (2001) Cytoplasmic polyamines as permeant blockers and modulators of the voltage-gated sodium channel. Biophys. J. 80, 1262–1279.

    PubMed  CAS  Google Scholar 

  18. Scott, R. H., Sutton, K. G., and Dolphin, A. C. (1993) Interactions of polyamines with neuronal ion channels. Trends Neurosci. 16, 153–160.

    Article  PubMed  CAS  Google Scholar 

  19. Choi, D. W. (1988) Glutamate neurotoxicity and diseases of the nervous system. Neuron 1, 623–634.

    Article  PubMed  CAS  Google Scholar 

  20. Lipton, S. A. and Rosenberg, P. A. (1994) Excitatory amino acids as a final common pathway for neurologic disorders. N. Engl. J. Med. 330, 613–622.

    Article  PubMed  CAS  Google Scholar 

  21. Schinder, A. F., Olson, E. C., Spitzer, N. C., and Montal, M. (1996) Mitochondrial dysfunction is a primary event in glutamate neurotoxicity. J. Neurosci. 16, 6125–6133.

    PubMed  CAS  Google Scholar 

  22. White, R. J. and Reynolds, I. J. (1996) Mitochondrial depolarization in glutamate-stimulated neurons: an early signal specific to excitotoxin exposure. J. Neurosci. 16, 5688–5697.

    PubMed  CAS  Google Scholar 

  23. Beatrice, M. C., Palmer, J. W., and Pfeiffer, D. R. (1980) The relationship between mitochondrial membrane permeability, membrane potential, and the retention of Ca2?? by mitochondria. J. Biol. Chem. 255, 8663–8671.

    PubMed  CAS  Google Scholar 

  24. Gunter, T. E. and Pfeiffer, D. R. (1990) Mechanisms by which mitochondria transport calcium. Am. J. Physiol. 258, C755–C786.

    PubMed  CAS  Google Scholar 

  25. Coyle, J. T. and Puttfarcken, P. (1993) Oxidative stress, glutamate, and neurodegenerative disorders. Science 262, 689–695.

    Article  PubMed  CAS  Google Scholar 

  26. Kirby, B. P. and Shaw, G. G. (2004) The neuroprotective effects of N1-dansyl-spermine in the gerbil model of cerebral ischaemia. Brain Res. 1011, 74–83.

    Article  PubMed  CAS  Google Scholar 

  27. Morrison, L. D., Cao, X. C., and Kish, S. J. (1998) Ornithine decarboxylase in human brain: Influence of aging, regional distribution, and Alzheimer’s disease. J. Neurochem. 71, 288–294.

    Article  PubMed  CAS  Google Scholar 

  28. Gilad, G. M. and Gilad, V. H. (1983) Polyamine biosynthesis is required for survival of sympathetic neurons after axonal injury. Brain Res. 273, 191–194.

    Article  PubMed  CAS  Google Scholar 

  29. Porcella, A., Carter, C., Fage, D., et al. (1991) The effects of N-methyl-D-aspartate and kainate lesions of the rat striatum on striatal ornithine decarboxylase activity and polyamine levels. Brain Res. 549, 205–212.

    Article  PubMed  CAS  Google Scholar 

  30. Gilad, G. M. and Gilad, V. H. (1988) Early polyamine treatment enhances survival of sympathetic neurons after postnatal axonal injury or immunosympathectomy. B rain Res. 466, 175–181.

    CAS  Google Scholar 

  31. Ha, H. C., Sirisoma, N. S., Kuppusamy, P., Zweier, J. L., Woster, P. M., and Casero, R. A., Jr. (1998) The natural polyamine spermine functions directly as a free radical scavenger. Proc. Natl. Acad. Sci. USA 95, 11,140–11,145.

    Article  PubMed  CAS  Google Scholar 

  32. Shimizu, H., Kakimoto, Y., and Sano, I. (1965) Changes in concentration of polyamines in the developing mouse brain. Nature 207, 1196–1197.

    Article  PubMed  CAS  Google Scholar 

  33. Cai, D., Deng, K., Mellado, W., Lee, J., Ratan, R., and Filbin, M. (2002) A rginase I and polyamines act downstream from cyclic A M P in overcoming inhibition of axonal growth MAG and myelin in vitro. Neuron 35, 711.

    Article  PubMed  CAS  Google Scholar 

  34. Clarke, J. R. and Tyms, A. S. (1991) Polyamine biosynthesis in cells infected with different clinical isolates of human cytomegalovirus. J. Med. Virol. 34, 212–216.

    Article  PubMed  CAS  Google Scholar 

  35. Seiler, N. (2000) Oxidation of polyamines and brain injury. Neurochem. Res. 25, 471–490.

    Article  PubMed  CAS  Google Scholar 

  36. Lee, S. J. and Lee, S. (2002) Toll-like receptors and inflammation in the CNS. Curr. Drug Targets Inflamm. Allergy 1, 181–191.

    Article  PubMed  CAS  Google Scholar 

  37. Wright, S. D. (1999) Toll, a new piece in the puzzle of innate immunity. J. Exp. Med. 189, 605–609.

    Article  PubMed  CAS  Google Scholar 

  38. Taveira da Silva, A. M., Kaulbach, H. C., Chuidian, F. S., Lambert, D. R., Suffredini, A. F., and Danner, R. L. (1993) Brief report: shock and multiple-organ dysfunction after selfadministration of Salmonella endotoxin. N. Engl. J. Med. 328, 1457–1460.

    Article  Google Scholar 

  39. Nguyen, M. D., Julien, J. P. and Rivest, S. (2002) Innate immunity: the missing link in neuroprotection and neurodegeneration? Nat. Rev. Neurosci. 3, 216–227.

    Article  PubMed  CAS  Google Scholar 

  40. Hasko, G., Kuhel, D. G., Marton, A., Nemeth, Z. H., Deitch, E. A., and Szabo, C. (2000) Spermine differentially regulates the production of interleukin-12 p40 and interleukin-10 and suppresses the release of the T helper 1 cytokine interferon-gamma. Shock 14, 144–149.

    Article  PubMed  CAS  Google Scholar 

  41. Messina, L., Arcidiacono, A., Spampinato, G., et al. (1990) Accumulation of ornithine decarboxylase mRNA accompanies activation of human and mouse monocytes/ macrophages. FEBS Lett. 268, 32–34.

    Article  PubMed  CAS  Google Scholar 

  42. Byrd, W. J., Jacobs, D. M., and Amoss, M. S. (1977) Synthetic polyamines added to cultures containing bovine sera reversibly inhibit in vitro parameters of immunity. Nature 267, 621–623.

    Article  PubMed  CAS  Google Scholar 

  43. Ferrante, A., Maxwell, G. M., Rencis, V. O., Allison, A. C., and Morgan, D. M. (1986) Inhibition of the respiratory burst of human neutrophils by the polyamine oxidasepolyamine system. Int. J. Immunopharmacol. 8, 411–417.

    Article  PubMed  CAS  Google Scholar 

  44. Quemener, V., Blanchard, Y., Chamaillard, L., Havouis, R., Cipolla, B., and Moulinoux, J. P. (1994) Polyamine deprivation: A new tool in cancer treatment. Anticancer Res. 14, 443–448.

    PubMed  CAS  Google Scholar 

  45. Zheng, S. A., McElwain, C. M., and Taffet, S. M. (1991) Regulation of mouse ornithine decarboxylase gene expression in a macrophage-like cell line: synergistic induction by bacterial lipopolysaccharide and cAMP. Biochem. Biophys. Res. Commun. 175, 48–54.

    Article  PubMed  CAS  Google Scholar 

  46. Szabo, C., Southan, G. J., Wood, E., Thiemermann, C., and Vane, J. R. (1994) Inhibition by spermine of the induction of nitric oxide synthase in J774.2 macrophages: Requirement of a serum factor. Br. J. Pharmacol. 112, 355–356.

    PubMed  CAS  Google Scholar 

  47. Molitor, J., Pace, W., Stunz, L., Vigna, J., Louie, S., and Ashman, R. (1994) Induction of ornithine decarboxylase activity in mouse B lymphocytes. Int. Immunol. 6, 1777–1784.

    Article  PubMed  CAS  Google Scholar 

  48. Tjandrawinata, R. R., Hawel, 3rd, L., and Byus, C. V. (1994) Regulation of putrescine export in lipopolysaccharide or IFN-gamma-activated murine monocytic-leukemic RAW 264 cells. J. Immunol. 152, 3039–3052.

    PubMed  CAS  Google Scholar 

  49. Zhang, M., Borovikova, L. V., Wang, H., Metz, C., and Tracey, K. J. (1999) Spermine inhibition of monocyte activation and inflammation. Mol. Med. 5, 595–605.

    PubMed  CAS  Google Scholar 

  50. Sugimoto, H., Matsuzaki, Y., Yuasa, K., et al. (1992) Estradiol-17 beta modifies the induction of spermidine/spermine N1-acetyltransferase activity in the liver of lipopolysaccharide-treated mice. Liver 12, 147–151.

    PubMed  CAS  Google Scholar 

  51. Zhang, M., Wang, H., and Tracey, K. J. (2000) Regulation of macrophage activation and inflammation by spermine: A new chapter in an old story. Crit. Care Med. 28, N60–N66.

    Article  PubMed  CAS  Google Scholar 

  52. Southan, G. J., Szabo, C., and Thiemermann, C. (1994) Inhibition of the induction of nitric oxide synthase by spermine is modulated by aldehyde dehydrogenase. B i o chem. Biophys. Res. Commun. 203, 1638–1644.

    Article  CAS  Google Scholar 

  53. Szabo, C., Southan, G. J., Thiemermann, C., and Vane, J. R. (1994) The mechanism of the inhibitory effect of polyamines on the induction of nitric oxide synthase: role of aldehyde metabolites. Br. J. Pharmacol. 113, 757–766.

    PubMed  CAS  Google Scholar 

  54. Bauer, P. M., Buga, G. M., Fukuto, J. M., Pegg, A. E., and Ignarro, L. J. (2001) Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme. J. Biol. Chem. 276, 34,458–34,464.

    Article  PubMed  CAS  Google Scholar 

  55. Ignarro, L.J., Buga, G. M., Wei, L. H., Bauer, P. M., Wu, G., and del Soldato, P. (2001) Role of the arginine-nitric oxide pathway in the regulation of vascular smooth muscle cell proliferation. Proc. Natl. Acad. Sci. USA 98, 4202–4208.

    Article  PubMed  CAS  Google Scholar 

  56. Nadeau, S. and Rivest, S. (2000) Role of microglial-derived tumor necrosis factor in mediating CD14 transcription and nuclear factor kappa B activity in the brain during endotoxemia. J. Neurosci. 20, 3456–3468.

    PubMed  CAS  Google Scholar 

  57. Nadeau, S. and Rivest, S. (2001) The complement system is an integrated part of the natural innate immune response in the brain. FASEB J. 15, 1410–1412.

    PubMed  CAS  Google Scholar 

  58. Laflamme, N., Soucy, G., and Rivest, S. (2001) Circulating cell wall components derived from gram-negative, not gram-positive, bacteria cause a profound induction of the geneencoding Toll-like receptor 2 in the CNS. J. Neurochem. 79, 648–657.

    Article  PubMed  CAS  Google Scholar 

  59. Laflamme, N. and Rivest, S. (2001) Toll-like receptor 4: the missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components. FASEB J. 15, 155–163.

    Article  PubMed  CAS  Google Scholar 

  60. Kilpelainen, P., Rybnikova, E., Hietala, O., and Pelto-Huikko, M. (2000) Expression of ODC and its regulatory protein antizyme in the adult rat brain. J. Neurosci. Res. 62, 675–685.

    Article  PubMed  CAS  Google Scholar 

  61. Soulet, D. and Rivest, S. (2003) Polyamines play a critical role in the control of the innate immune response in the mouse central nervous system. J. Cell. Biol. 162, 257–268.

    Article  PubMed  CAS  Google Scholar 

  62. Gottlieb, M. and Matute, C. (1997) Expression of ionotropic glutamate receptor subunits in glial cells of the hippocampal CA1 area following transient forebrain ischemia. J. Cereb. Blood Flow Metab. 17, 290–300.

    Article  PubMed  CAS  Google Scholar 

  63. Kingham, P. J., Cuzner, M. L., and Pocock, J. M. (1999) Apoptotic pathways mobilized in microglia and neurones as a consequence of chromogranin A-induced microglial activation. J. Neurochem. 73, 538–547.

    Article  PubMed  CAS  Google Scholar 

  64. Oka, A., Belliveau, M. J., Rosenberg, P. A., and Volpe, J. J. (1993) Vulnerability of oligodendroglia to glutamate: pharmacology, mechanisms, and prevention. J. Neurosci. 13, 1441–1453.

    PubMed  CAS  Google Scholar 

  65. Sanchez-Gomez, M. V. and Matute, C. (1999) AMPA and kainate receptors each mediate excitotoxicity in oligodendroglial cultures. Neurobiol. Dis. 6, 475–485.

    Article  PubMed  CAS  Google Scholar 

  66. Baimbridge, K. G., Celio, M. R., and Rogers, J. H. (1992) Calcium-binding proteins in the nervous system. Trends Neurosci. 15, 303–308.

    Article  PubMed  CAS  Google Scholar 

  67. Nguyen, M. D., Julien, J. P. and Rivest. S. (2002) Innate immunity: the missing link in neuroprotection and neurodegeneration? Nat. Rev. Neurosci. 3, 216–227.

    Article  PubMed  CAS  Google Scholar 

  68. McKay, L. I. and Cidlowski, J. A. (1999) Molecular control of immune/inflammatory responses: Interactions between nuclear factor-kappa B and steroid receptor-signaling pathways. Endocr. Rev. 20, 435–459.

    Article  PubMed  CAS  Google Scholar 

  69. Nadeau, S. and Rivest, S. (2002) Endotoxemia prevents the cerebral inflammatory wave induced by intraparenchymal lipopolysaccharide injection: Role of glucocorticoids and CD14. J. Immunol. 169, 3370–3381.

    PubMed  CAS  Google Scholar 

  70. Nadeau, S. and Rivest, S. (2003) Glucocorticoids play a fundamental role in potecting the brain during innate immune response. J. Neurosci. 23, 5536–5544.

    PubMed  Google Scholar 

  71. Zhang, M., Caragine, T., Wang, H., et al. (1997) Spermine inhibits proinflammatory cytokine synthesis in human mononuclear cells: A counterregulatory mechanism that restrains the immune response. J. Exp. Med. 185, 1759–1768.

    Article  PubMed  CAS  Google Scholar 

  72. Nomura, F., Akashi, S., Sakao, Y., et al. (2000) Cutting edge: Endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression. J. Immunol. 164, 3476–3479.

    PubMed  CAS  Google Scholar 

  73. Gomes-Trolin, C., Nygren, I., Aquilonius, S. M., and Askmark, H. (2002) Increased red blood cell polyamines in ALS and Parkinson’s disease. Exp. Neurol. 177, 515–520.

    Article  PubMed  CAS  Google Scholar 

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Soulet, D., Rivest, S. (2006). Role of Polyamines in the Control of the Immune Response in the Brain. In: Wang, JY., Casero, R.A. (eds) Polyamine Cell Signaling. Humana Press. https://doi.org/10.1007/978-1-59745-145-1_16

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