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Smoking-Related Small Airways and Interstitial Lung Disease

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Book cover CT of the Airways

Part of the book series: Contemporary Medical Imaging ((CMI))

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Summary

The consequences of airways and interstitial inflammation caused by cigarette smoking are many and varied. In addition to well-recognized smoking-related disorders, including chronic bronchitis and emphysema, there is increasing appreciation of the complex relationship between small airways and interstitial damage, typified by respiratory bronchiolitis interstitial lung disease. Individual diseases ascribable to cigarette smoking and their relationship to each other are described.

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References

  1. Niewoehner DE, Kleinerman J, Rice DB. Pathologic changes in the peripheral airways of young cigarette smokers. N. Engl. J. Med. 1974;291:775–777.

    Article  Google Scholar 

  2. Myers JL, Veal CF, Shin MS, Katzenstein ALA. Respiratory bronchiolitis causing interstitial lung disease: a clinicopathologic study of six cases. Am. Rev. Respir. Dis. 1987;135:880–884.

    PubMed  CAS  Google Scholar 

  3. Guerry-Force ML, Müller NL, Wright JL, et al. A comparison of bronchiolitis obliterans with organizing pneumonia, usual interstitial pneumonia and small airways disease. Am. Rev. Respir. Dis. 1987;135:705–712.

    PubMed  CAS  Google Scholar 

  4. Yousem SA, Colby TV, Gaensler EA. Respiratory bronchiolitis-associated interstitial lung disease and its relationship to desquamative interstitial pneumonia. Mayo Clin. Proc. 1989;64:1373–1380.

    PubMed  CAS  Google Scholar 

  5. Fraig M, Shreesha U, Savici D, Katzenstein AL. Respiratory bronchiolitis: a clinicopathologic study in current smokers, ex-smokers, and never-smokers. Am J Surg.Pathol 2002;26:647–653.

    Article  PubMed  Google Scholar 

  6. Cottin V, Streichenberger N, Gamondes JP, et al. Respiratory bronchiolitis in smokers with spontaneous pneumothorax. Eur. Respir. J. 1998;12:702–704.

    Article  PubMed  CAS  Google Scholar 

  7. Remy-Jardin M, Remy J, Gosselin B, Becette V, Edme JL. Lung parenchymal changes secondary to cigarette smoking: pathologic-CT correlations. Radiology 1993;186:643–651.

    PubMed  CAS  Google Scholar 

  8. Agius RM, Rutman A, Knight RK, Cole PJ. Human pulmonary alveolar macrophages with smokers’ inclusions: their relation to the cessation of cigarette smoking. Br. J. Exp. Pathol. 1986;67:407–413.

    PubMed  CAS  Google Scholar 

  9. Moon J, Du Bois RM, Colby TV, Hansell DM, Nicholson AG. Clinical significance of respiratory bronchiolitis on open lung biopsy and its relationship to smoking related interstitial lung disease. Thorax 1999;54:1009–1014.

    PubMed  CAS  Google Scholar 

  10. Elkin SL, Nicholson AG, Du Bois RM. Desquamative interstitial pneumonia and respiratory bronchiolitis-associated interstitial lung disease. Semin. Respir. Crit Care Med. 2001;22:387–398.

    Article  PubMed  CAS  Google Scholar 

  11. King TE. Respiratory bronchiolitis-associated interstitial lung disease. Clin. Chest. Med. 1993;14:693–698.

    PubMed  Google Scholar 

  12. Heyneman LE, Ward S, Lynch DA, Remy-Jardin M, Johkoh T, Müller NL. Respiratory bronchiolitis, respiratory bronchiolitis-associated interstitial lung disease, and desquamative interstitial pneumonia: different entities or part of the spectrum of the same disease process? AJR 1999;173:1617–1622.

    PubMed  CAS  Google Scholar 

  13. Nicholson AG, Colby TV, Du Bois RM, Hansell DM, Wells AU. The prognostic significance of the histologic pattern of interstitial pneumonia in patients presenting with the clinical entity of cryptogenic fibrosing alveolitis. Am. J. Respir. Crit. Care Med. 2000;162:2213–2217.

    PubMed  CAS  Google Scholar 

  14. Veeraraghavan S, Latsi PI, Wells AU, et al. BAL findings in idiopathic nonspecific interstitial pneumonia and usual interstitial pneumonia. Eur. Respir. J. 2003;22:239–244.

    Article  PubMed  CAS  Google Scholar 

  15. Drent M, van Nierop MA, Gerritsen FA, Wouters EF, Mulder PG. A computer program using BALF-analysis results as a diagnostic tool in interstitial lung diseases. Am. J. Respir. Crit Care Med. 1996;153:736–741.

    PubMed  CAS  Google Scholar 

  16. Park JS, Brown KK, Tuder RM, Hale VA, King TE Jr, Lynch DA. Respiratory bronchiolitis-associated interstitial lung disease: radiologic features with clinical and pathologic correlation. J. Comput. Assist. Tomogr. 2002;26:13–20.

    Article  PubMed  Google Scholar 

  17. Prigent A, Lamblin C, Copin MC, Wallaert B. [Respiratory bronchiolitis with diffuse interstitial lung disease]. Rev. Mal Respir. 2001;18:201–204.

    PubMed  CAS  Google Scholar 

  18. Remy-Jardin M, Remy J, Boulenguez C, Sobaszek A, Edme JL, Furon D. Morphologic effects of cigarette smoking on airways and pulmonary parenchyma in healthy adult volunteers: CT evaluation and correlation with pulmonary function tests. Radiology 1993;186:107–115.

    PubMed  CAS  Google Scholar 

  19. Müller NL, Miller RR. Diseases of the bronchioles: CT and histopathologic findings. Radiology 1995;196:3–12.

    PubMed  Google Scholar 

  20. Remy-Jardin M, Edme JL, Boulenguez C, Remy J, Mastora I, Sobaszek A. Longitudinal follow-up study of smoker’s lung with thin-section CT in correlation with pulmonary function tests. Radiology 2002;222:261–270.

    Article  PubMed  Google Scholar 

  21. Holt RM, Schmidt RA, Godwin JD, Raghu G. High resolution CT in respiratory bronchiolitis-associated interstitial lung disease. J. Comput. Assist. Tomogr. 1993;17:46–50.

    PubMed  CAS  Google Scholar 

  22. Essadki O, Chartrand-Lefebvre C, Briere J, Grenier P. Respiratory bronchiolitis: radiographic and CT findings in a pathologically proven case. Eur. Radiol. 1998;8:1674–1676.

    Article  PubMed  CAS  Google Scholar 

  23. Verschakelen JA, Scheinbaum K, Bogaert J, Demedts M, Lacquet LL, Baert AL. Expiratory CT in cigarette smokers: correlation between areas of decreased lung attenuation, pulmonary function tests and smoking history. Eur. Radiol. 1998;8:1391–1399.

    Article  PubMed  CAS  Google Scholar 

  24. Mastora I, Remy-Jardin M, Sobaszek A, Boulenguez C, Remy J, Edme JL. Thin-section CT finding in 250 volunteers: assessment of the relationship of CT findings with smoking history and pulmonary function test results. Radiology 2001;218:695–702.

    PubMed  CAS  Google Scholar 

  25. Hansell DM, Wells AU, Padley SPG, Müller NL. Hypersensitivity pneumonitis: correlation of individual CT patterns with functional abnormalities. Radiology 1996;199:123–128.

    PubMed  CAS  Google Scholar 

  26. Hartman TE, Primack SL, Swensen SJ, Hansell D, McGuinness G, Müller NL. Desquamative interstitial pneumonia: thin-section CT findings in 22 patients. Radiology 1993;187:787–790.

    PubMed  CAS  Google Scholar 

  27. Carrington CB, Gaensler EA, Coutu RE, Fitzgerald MX, Gupta RG. Natural history and treated course of usual and desquamative interstitial pneumonia. N. Engl. J. Med. 1978;298:801–809.

    Article  PubMed  CAS  Google Scholar 

  28. Corrin B, Price AB. Electron microscopic studies in desquamative interstitial pneumonia associated with asbestos. Thorax 1972;27:324–331.

    PubMed  CAS  Google Scholar 

  29. Abraham JL, Hertzberg MA. Inorganic particulates associated with desquamative interstitial pneumonia. Chest 1981;80:67–70.

    PubMed  CAS  Google Scholar 

  30. Bone RC, Wolfe J, Sobonya RE, et al. Desquamative interstitial pneumonia following long-term nitrofurantoin therapy. Am. J. Med. 1976;60:697–701.

    Article  PubMed  CAS  Google Scholar 

  31. Amir G, Ron N. Pulmonary pathology in Gaucher’s disease. Hum. Pathol. 1999;30:666–670.

    Article  PubMed  CAS  Google Scholar 

  32. Craig PJ, Wells AU, Doffman S, et al. Desquamative interstitial pneumonia, respiratory bronchiolitis and their relationship to smoking. Histopathology 2004;45:275–282.

    Article  PubMed  CAS  Google Scholar 

  33. Liebow AA, Steer A, Billingsley JG. Desquamative interstitial pneumonitis. Am. J. Med. 1965;39:369–404.

    Article  PubMed  CAS  Google Scholar 

  34. Myers JL, Aubry MC. Pulmonary langerhans cell histiocytosis: what was the question? Am. J. Respir. Crit. Care Med. 2002;166:1419–1421.

    Article  PubMed  Google Scholar 

  35. Lichtenstein L. Histiocytosis X. Integration of eosinophilic granuloma of bone, ‘Letterer-Slwe disease’ and ‘Schuller-Christian disease’ as related manifestations of a single nosologic entity. Arch. Pathol. 1953;56:84–102.

    CAS  Google Scholar 

  36. Colby TV, Lombard C. Histiocytosis X in the lung. Hum. Pathol. 1983;14:847–856.

    Article  PubMed  CAS  Google Scholar 

  37. Kambouchner M, Basset F, Marchal J, Uhl JF, Hance AJ, Soler P. Three-dimensional characterization of pathologic lesions in pulmonary langerhans cell histiocytosis. Am. J. Respir. Crit Care Med. 2002;166:1483–1490.

    Article  PubMed  Google Scholar 

  38. Habib SB, Congleton J, Carr D, et al. Recurrence of recipient Langerhans’ cell histiocytosis following bilateral lung transplantation. Thorax 1998;53:323–325.

    Article  PubMed  CAS  Google Scholar 

  39. Travis WD, Borok Z, Roum JH, et al. Pulmonary Langerhans cell granulomatosis (histiocytosis X). A clinicopathologic study of 48 cases. Am. J. Surg. Pathol. 1993;17:971–986.

    Article  PubMed  CAS  Google Scholar 

  40. Fartoukh M, Humbert M, Capron F, et al. Severe pulmonary hypertension in histiocytosis X. Am. J. Respir. Crit. Care Med. 2000;161:216–223.

    PubMed  CAS  Google Scholar 

  41. Lacronique J, Roth C, Battesti JP, Basset F, Chretien J. Chest radiological features of pulmonary histiocytosis X: a report based on 50 adult cases. Thorax 1982;37:104–109.

    PubMed  CAS  Google Scholar 

  42. Khoor A, Myers JL, Tazelaar HD, Swensen SJ. Pulmonary Langerhans cell histiocytosis presenting as a solitary nodule. Mayo Clin. Proc. 2001;76:209–211.

    Article  PubMed  CAS  Google Scholar 

  43. Donnelly LF, Frush DP. Langerhans’ cell histiocytosis showing low-attenuation mediastinal mass and cystic lung disease. AJR Am. J. Roentgenol. 2000;174:877–878.

    PubMed  CAS  Google Scholar 

  44. Primack SL, Hartman TE, Hansell DM, Müller NL. End-stage lung disease: CT findings in 61 patients. Radiology 1993;189:681–686.

    PubMed  CAS  Google Scholar 

  45. Brauner MW, Grenier P, Mouelhi MM, Mompoint D, Lenoir S. Pulmonary histiocytosis X: evaluation with high-resolution CT. Radiology 1989;172:255–258.

    PubMed  CAS  Google Scholar 

  46. Brauner MW, Grenier P, Tijani K, Battesti JP, Valeyre D. Pulmonary Langerhans cell histiocytosis: evolution of lesions on CT scans. Radiology 1997;204:497–502.

    PubMed  CAS  Google Scholar 

  47. Soler P, Bergeron A, Kambouchner M, et al. Is high-resolution computed tomography a reliable tool to predict the histopathological activity of pulmonary Langerhans cell histiocytosis? Am. J. Respir. Crit. Care Med. 2000;162:264–270.

    PubMed  CAS  Google Scholar 

  48. Gabbay E, Dark JH, Ashcroft T, et al. Recurrence of Langerhans’ cell granulomatosis following lung transplantation. Thorax 1998;53:326–327.

    PubMed  CAS  Google Scholar 

  49. Selman M. The spectrum of smoking-related interstitial lung disorders: the never-ending story of smoke and disease. Chest 2003;124:1185–1187.

    Article  PubMed  Google Scholar 

  50. Vassallo R, Jensen EA, Colby TV, et al. The overlap between respiratory bronchiolitis and desquamative interstitial pneumonia in pulmonary Langerhans cell histiocytosis: high-resolution CT, histologic, and functional correlations. Chest 2003;124:1199–1205.

    Article  PubMed  Google Scholar 

  51. Wells AU, King AD, Rubens MB, Cramer D, Du Bois RM, Hansell DM. Lone cryptogenic fibrosing alveolitis: a functional-morphologic correlation based on extent of disease on thin-section computed tomography. Am. J. Respir. Crit. Care Med. 1997;155:1367–1375.

    PubMed  CAS  Google Scholar 

  52. Shintani H, Fujimura M, Yasui M, et al. Acute eosinophilic pneumonia caused by cigarette smoking. Intern. Med. 2000;39:66–68.

    Article  PubMed  CAS  Google Scholar 

  53. Nakajima M, Manabe T, Niki Y, Matsushima T. Cigarette smoke-induced acute eosinophilic pneumonia. Radiology 1998;207:829–831.

    PubMed  CAS  Google Scholar 

  54. Watanabe K, Fujimura M, Kasahara K, et al. Acute eosinophilic pneumonia following cigarette smoking: a case report including cigarette-smoking challenge test. Intern. Med. 2002;41:1016–1020.

    Article  PubMed  Google Scholar 

  55. Greene R. “Saber-sheath” trachea: relation to chronic obstructive pulmonary disease. AJR Am. J. Roentgenol. 1978;130:441–445.

    PubMed  CAS  Google Scholar 

  56. Bobadilla A, Guerra S, Sherrill D, Barbee R. How accurate is the self-reported diagnosis of chronic bronchitis? Chest 2002;122:1234–1239.

    Article  PubMed  Google Scholar 

  57. Sunyer J, Jarvis D, Gotschi T, et al. Chronic bronchitis and urban air pollution in an international study. Occup. Environ. Med. 2006;63:836–843.

    Article  PubMed  CAS  Google Scholar 

  58. Matsuoka S, Uchiyama K, Shima H, Ueno N, Oish S, Nojiri Y. Bronchoarterial ratio and bronchial wall thickness on high-resolution CT in asymptomatic subjects: correlation with age and smoking. AJR Am. J. Roentgenol. 2003;180: 513–518.

    PubMed  Google Scholar 

  59. Guest PJ, Hansell DM. High resolution computed tomography in emphysema associated with alpha-1-antitrypsin deficiency. Clin. Radiol. 1992;45:260–266.

    Article  PubMed  CAS  Google Scholar 

  60. Gamsu G, Nadel JA. The roentgenologic manifestations of emphysema and chronic bronchitis. Med. Clin. North Am. 1973;57:719–733.

    PubMed  CAS  Google Scholar 

  61. Guckel C, Hansell DM. Imaging the ‘dirty lung’–has high resolution computed tomography cleared the smoke? Clin. Radiol. 1998;53:717–722.

    Article  PubMed  CAS  Google Scholar 

  62. Berger P, Laurent F, Begueret H, et al. Structure and function of small airways in mokers: relationship between air trapping at CT and airway inflammation. Radiology 2003;228:85–94.

    Article  PubMed  Google Scholar 

  63. Grenier P, Mourey-Gerosa I, Benali K, et al. Abnormalities of the airways and lung parenchyma in asthmatics: CT observations in 50 patients and inter- and intra-observer variability. Eur. Radiol. 1996;6:199–206.

    Article  PubMed  CAS  Google Scholar 

  64. Diederich S, Jurriaans E, Flower CDR. Interobserver variation in the diagnosis of bronchiectasis on high-resolution computed tomography. Eur. Radiol. 1996;6:801–806.

    Article  PubMed  CAS  Google Scholar 

  65. Orlandi I, Moroni C, Camiciottoli G, et al. Chronic obstructive pulmonary disease: thin-section CT measurement of airway wall thickness and lung attenuation. Radiology 2005;234:604–610.

    Article  PubMed  Google Scholar 

  66. Berger P, Perot V, Desbarats P, Tunon-de-Lara JM, Marthan R, Laurent F. Airway wall thickness in cigarette smokers: quantitative thin-section CT assessment. Radiology 2005;235:1055–1064.

    Article  PubMed  Google Scholar 

  67. Nakano Y, Muro S, Sakai H, et al. Computed tomographic measurements of airway dimensions and emphysema in smokers. Correlation with lung function. Am. J. Respir. Crit. Care Med. 2000;162:1102–1108.

    PubMed  CAS  Google Scholar 

  68. Aziz ZA, Wells AU, Desai SR, et al. Functional impairment in emphysema: contribution of airway abnormalities and distribution of parenchymal disease. AJR Am. J. Roentgenol. 2005;185:1509–1515.

    Article  PubMed  Google Scholar 

  69. Zompatori M, Sverzellati N, Gentile T, Spaggiari L, Laporta T, Fecci L. Imaging of the patient with chronic bronchitis: an overview of old and new signs. Radiol. Med. (Torino) 2006;111:634–639.

    Article  CAS  Google Scholar 

  70. Gamsu G, Forbes AR, Ovenfors CO. Bronchographic features of chronic bronchitis in normal men. AJR Am. J. Roentgenol. 1981;136:317–322.

    PubMed  CAS  Google Scholar 

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Authors
  1. David M. Hansell
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  2. Athol U. Wells
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Editors and Affiliations

  1. Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA

    Phillip M. Boiselle MD

  2. Department of Radiology, National Jewish Medical and Research Center, Denver, CO

    David A. Lynch MB

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© 2008 Humana Press

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Hansell, D.M., Wells, A.U. (2008). Smoking-Related Small Airways and Interstitial Lung Disease. In: Boiselle, P.M., Lynch, D.A. (eds) CT of the Airways. Contemporary Medical Imaging. Humana Press. https://doi.org/10.1007/978-1-59745-139-0_14

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  • DOI: https://doi.org/10.1007/978-1-59745-139-0_14

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-848-5

  • Online ISBN: 978-1-59745-139-0

  • eBook Packages: MedicineMedicine (R0)

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