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Cholestatic Variants of Viral Disease and Alcohol

  • Chapter
Cholestatic Liver Disease

Part of the book series: Clinical Gastroenterology ((CG))

Abstract

Hepatitis of any etiology routinely presents with elevated transaminases. However, the presence of cholestasis should not necessarily rule out the presence of viral or alcoholic hepatitis. Hepatotropic viruses, such as hepatitis A, B, C, and E, can present with an elevated alkaline phosphatase and hyperbilirubinemia. Cytomegalovirus and Epstein-Barr virus infections may also present in this manner. Alcoholic hepatitis, often defined by an AST/ALT ratio of 2–3:1, can have cholestatic characteristics, as well. A careful clinical history, viral serologies, and, in some cases, a liver biopsy can clarify these disease states.

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  1. Washington University School of Medicine, St. Louis, MO

    Sakib Khalid MD & Jeffrey S. Crippin MD

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  1. Mayo Clinic, Rochester, MN

    Keith D. Lindor MD  & Jayant A. Talwalkar MD  & 

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Khalid, S., Crippin, J.S. (2008). Cholestatic Variants of Viral Disease and Alcohol. In: Lindor, K.D., Talwalkar, J.A. (eds) Cholestatic Liver Disease. Clinical Gastroenterology. Humana Press. https://doi.org/10.1007/978-1-59745-118-5_7

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  • DOI: https://doi.org/10.1007/978-1-59745-118-5_7

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