Delayed Sleep Phase Syndrome in Adolescents

  • John Garcia
Part of the Current Clinical Neurology book series (CCNEU)


To some degree, delayed sleep phase syndrome (DSPS) is present in most, if not all adolescents. It is thought to be a normal biological developmental phase. Thorpy et al. (1) first described its common presence in teenagers in 1988, and, in 1993, Carskadon et al. (2) first linked it to the biological process of puberty. The relationship was more significant in girls than in boys.


Circadian Rhythm Excessive Daytime Sleepiness Wake Time Sleep Phase Recovery Sleep 
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  1. 1.
    Thorpy, M.J., E. Korman, A.J. Spielman, and P.B. Glovinsky, Delayed sleep phase syndrome in adolescents. J Adolesc Health Care, 1988;9(1):22–27.PubMedCrossRefGoogle Scholar
  2. 2.
    Carskadon M.A., C. Vieira, and C. Acebo, Association between puberty and delayed phase preference. Sleep, 1993;16(3):258–262.PubMedGoogle Scholar
  3. 3.
    Touitou, Y., Human aging and melatonin: clinical relevance. Exp Gerontol, 2001;36(7):1083–1100.PubMedCrossRefGoogle Scholar
  4. 4.
    Dijk, D. and S. Lockley, Integration of human sleep-wake regulation and circadian rhythmicity. J Appl Physiol, 2002;92:852–862.PubMedGoogle Scholar
  5. 5.
    Borbely, A., A two process model of sleep regulation. Hum Neurobiol, 1982;1:195–204.PubMedGoogle Scholar
  6. 6.
    Pealy R. and P. Bovinski, Prevalence of delayed sleep phase syndrome among adolescents. Sleep Res, 1998;17:362.Google Scholar
  7. 7.
    Ando K. and S. Ancoli-Israiel, Estimated prevalence of delayed and advanced sleep phase syndromes. Sleep Res, 1995;24:509.Google Scholar
  8. 8.
    Shibui, K., M. Uchiyama, and M. Okawa, Melatonin rhythms in delayed sleep phase syndrome. J Biol Rhythms, 1999;14(1):72–76.PubMedCrossRefGoogle Scholar
  9. 9.
    Uchiyama, M., M. Okawa, K. Shibui, et al., Poor recovery sleep after sleep deprivation in delayed sleep phase syndrome. Psychiatry Clin Neurosci, 1999;53(2):195–197.PubMedCrossRefGoogle Scholar
  10. 10.
    Shirayama, M., Y. Shirayama, H. Iida, et al., The psychological aspects of patients with delayed sleep phase syndrome (DSPS). Sleep Med, 2003; 4(5):427–433.PubMedCrossRefGoogle Scholar
  11. 11.
    Rosenthal, N., J.R. Joseph-Vanderpool, A.A. Levendosky, et al., Phase-shifting effects of bright morning light as treatment for delayed sleep phase syndrome. Sleep, 1990;13(4):354–361.PubMedGoogle Scholar
  12. 12.
    Khalsa, S., M.E. Jewett, C. Cajochen, and C.A. Czeisler, A phase response curve to single bright light pulses in human subjects. J Physiol, 2003;549(3):945–952.PubMedCrossRefGoogle Scholar
  13. 13.
    Chesson, A. L. Jr., M. Littner, D. Davila, et al., Practice parameters for the use of light therapy in the treatment of sleep disorders. Standards of Practice Committee, American Academy of Sleep Medicine. Sleep, 1999;22:641–660.PubMedGoogle Scholar
  14. 14.
    Wyatt, J., Delayed sleep phase syndrome: pathophysiology and treatment options. Sleep, 2004;27(6):1195–1203.PubMedGoogle Scholar
  15. 15.
    Regestein, Q., Treating insomnia: a practical guide for managing chronic sleeplessness. Compr Psychiatry, 1975;17(4):517–526.CrossRefGoogle Scholar
  16. 16.
    Czeisler, C., G.G. Richardson, R.M. Coleman, et al., Chronotherapy: resetting the circadian clocks of patients with delayed sleep phase insomnia. Sleep, 1981;4(1):1–21.PubMedGoogle Scholar
  17. 17.
    Weitzman, E., C.A. Czeisler, R.M. Coleman, et al., Delayed sleep phase syndrome. A chronobiological disorder with sleep-onset insomnia. Arch Gen Psychiatry, 1981;38(7):737–746.PubMedGoogle Scholar
  18. 18.
    Pelayo, R.M., W. Chen, S. Monzon, and Guilleminault, C. Pediatric sleep pharmacology: you want to give my kid sleeping pills? Pediatr Clin North Am, 2004;51(1):117–134.PubMedCrossRefGoogle Scholar
  19. 19.
    Kamei, Y., T. Hayakawa, J. Urata, et al., Melatonin treatment for circadian rhythm sleep disorders. Psychiatry Clin Neurosci, 2000;54(3):381–382.PubMedCrossRefGoogle Scholar
  20. 20.
    Smits, M., J.E. Nagtegaal, J. van der Heijden, A.M. Coenen, and G.A. Kerkhof, Melatonin for chronic sleep onset insomnia in children: a randomized placebo-controlled trial. J Child Neurol, 2001;16(2):86–92.PubMedCrossRefGoogle Scholar
  21. 21.
    Dagan, Y., I. Yovel, D. Hallis, H. Eisenstin, and I. Raichik, Evaluating the role of melatonin in the long-term treatment of delayed sleep phase syndrome. Chronobiol Int, 1998;15(2):181–190.PubMedCrossRefGoogle Scholar
  22. 22.
    Lewy, A.J., J. Emens, R.L. Sack, B.P. Hasler, and R.A. Bernert, Zeitgeber hierarchy in humans: resetting the circadian phase positions of blind people using melatonin. Chronobiol Int, 2003;20(5):837–852.PubMedCrossRefGoogle Scholar
  23. 23.
    Hack, L.M., S.W. Lockley, J. Arendt, and D.J. Skene, The effects of low-dose 0.5 mg melatonin on the free-running circadian rhythms of blind subjects. J Biol Rhythms, 2003;18(5):430–429.CrossRefGoogle Scholar
  24. 24.
    Wagner, J., M. Wagner, and W. Hening, Beyond benzodiazepines: alternative pharmacologic agents for the treatment of insomnia. Ann Pharmacother, 1998;32(6):680–691.PubMedCrossRefGoogle Scholar
  25. 25.
    Satoh, K., K. Mishima, Y. Inoue, T. Ebisawa, and T. Shimizu, Two pedigrees of familial advanced sleep phase syndrome in Japan. Sleep, 2003;24(4):416–417.Google Scholar
  26. 26.
    Carskadon, M., Forced desynchrony as a means of assessing circadian and sleep/wake homeostatic, 2004;
  27. 27.
    Littner, M., C.A. Kushida, W.M. Anderson, et al., and the Standards of Practice Committee of the American Academy of Sleep Medicine. Practice parameters for the role of actigraphy in the study of sleep and circadian rhythms: an update for 2002. Sleep, 2003;26(3):337–341.PubMedGoogle Scholar

Copyright information

© Humana Press Inc., Totowa, NJ 2006

Authors and Affiliations

  • John Garcia
    • 1
  1. 1.Departments of Pediatrics and Neurology, Minnesota Regional Sleep CenterHennepin County Medical Center/University of MinnesotaMinneapolis

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