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Restless Legs Syndrome and Menopause

  • Nancy S. Collins
Part of the Current Clinical Neurology book series (CCNEU)

Abstract

There is no known pathophysiological link and, indeed, very little in the literature written about menopause and restless legs syndrome (RLS). Because the cellular mechanisms explaining the causality of RLS are unknown, much literature has focused on numerous associations in order to discover the etiology and pathophysiology of the disorder in men and women. Some widely held generalizations occur in the literature, including characterizions of the disorder as commonly occurring in middle to late age and with higher prevalence in women. Following this line of logic, one would naturally posit a relationship between RLS and menopause. However, as is discussed in this chapter, these widely held generalizations need to be reexamined in the context of recent epidemiological population- and patient-based data so that the information gathered from the clinical and basic sciences can best be integrated and possible mechanisms underlying RLS discovered, including what role, if any, changes associated with menopause may play in the disorder.

Keywords

Melatonin Level Melatonin Secretion Dopaminergic Dysfunction Periodic Limb Movement Disorder Plasma Melatonin Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Kavanagh, D., S. Siddiqui, and C.C. Geddes, Restless legs syndrome in patients on dialysis. Am J Kidney Dis, 2004;43(5):763–771.PubMedCrossRefGoogle Scholar
  2. 2.
    Allen, R.P., D. Picchiettti, W.A. Hening, C. Trenkwalder, A.S. Walters, and J. Montplaisir, Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med, 2003;4(2):101–119.PubMedCrossRefGoogle Scholar
  3. 3.
    Berger, K., J. Luedemann, C. Trenkwalder, U. John, and C. Kessler, Sex and the risk of restless legs syndrome in the general population. Arch Intern Med, 2004;164(2):196–202.PubMedCrossRefGoogle Scholar
  4. 4.
    Schapira, A.H., Restless legs syndrome: an update on treatment options. Drugs, 2004;64(2):149–158.PubMedCrossRefGoogle Scholar
  5. 5.
    Hornyak, M. and C. Trenkwalder, Restless legs syndrome and periodic limb movement disorder in the elderly. J Psychosom Res, 2004;56(5):543–548.PubMedCrossRefGoogle Scholar
  6. 6.
    Turjanski, N., A.J. Lees, and D.J. Brooks, Striatal dopaminergic function in restless legs syndrome: 18F-dopa and 11C-raclopride PET studies. Neurology, 1999;52(5):932–937.PubMedGoogle Scholar
  7. 7.
    Trenkwalder, C. and W. Paulus, Why do restless legs occur at rest?-pathophysiology of neuronal structures in RLS. Neurophysiology of RLS (part 2). Clin Neurophysiol, 2004;115(9):1975–1988.PubMedCrossRefGoogle Scholar
  8. 8.
    Garcia-Borreguero, D., O. Larrosa, J.J. Granizo, Y. de la Llave, and W.A. Hening, Circadian effects of dopaminergic treatment in restless legs syndrome. Sleep Med, 2004;5(4):413–420.PubMedCrossRefGoogle Scholar
  9. 9.
    Chesson, A.L., Jr., M. Wise, D. Davila, et al., Practice parameters for the treatment of restless legs syndrome and periodic limb movement disorder. An American Academy of Sleep Medicine Report. Standards of Practice Committee of the American Academy of Sleep Medicine. Sleep, 1999;22(7):961–968.PubMedGoogle Scholar
  10. 10.
    Walters, A.S., K. Hickey, J. Maltzman, et al., A questionnaire study of 138 patients with restless legs syndrome: the ‘Night-Walkers’ survey. Neurology, 1996;46(1):92–95.PubMedGoogle Scholar
  11. 11.
    Garcia-Borreguero, D., P. Odin, and C. Schwarz, Restless legs syndrome: an overview of the current understanding and management. Acta Neurol Scand, 2004;109(5):303–317.PubMedCrossRefGoogle Scholar
  12. 12.
    Phillips, B., T. Young, L. Finn, K. Asher, W.A. Hening, and C. Purvis, Epidemiology of restless legs symptoms in adults. Arch Intern Med, 2000;160(14):2137–2141.PubMedCrossRefGoogle Scholar
  13. 13.
    Winkelmann, J., T.C. Wetter, V. Collado-Seidel, et al., Clinical characteristics and frequency of the hereditary restless legs syndrome in a population of 300 patients. Sleep, 2000;23(5):597–602.PubMedGoogle Scholar
  14. 14.
    Rothdach, A.J., C. Trenkwalder, J. Haberstock, U. Keil, and K. Berger, Prevalence and risk factors of RLS in an elderly population: the MEMO study. Memory and Morbidity in Augsburg Elderly. Neurology, 2000;54(5):1064–1068.PubMedGoogle Scholar
  15. 15.
    Allen, R.P., A.S. Walters, J. Montplaisir, et al., Restless legs syndrome prevalence and impact: REST general population study. Arch Intern Med, 2005;165(11):1286–1292.PubMedCrossRefGoogle Scholar
  16. 16.
    Montplaisir, J., S. Boucher, G. Poirier, G. Lavigne, O. Lapierre, and P. Lesperance, Clinical, polysomnographic, and genetic characteristics of restless legs syndrome: a study of 133 patients diagnosed with new standard criteria. Mov Disord, 1997;12(1):61–65.PubMedCrossRefGoogle Scholar
  17. 17.
    Ondo, W. and J. Jankovic, Restless legs syndrome: clinicoetiologic correlates. Neurology, 1996;47(6):1435–1441.PubMedGoogle Scholar
  18. 18.
    Trenkwalder, C., Restless-legs syndrome in primary care: counting patients in Idaho. Lancet Neurol, 2004;3(2):83.PubMedCrossRefGoogle Scholar
  19. 19.
    Ondo, W.G., K.D. Vuong, and Q. Wang, Restless legs syndrome in monozygotic twins: clinical correlates. Neurology, 2000;55(9):1404–1406.PubMedGoogle Scholar
  20. 20.
    Tison, F., A. Crochard, D. Leger, S. Bouee, E. Lainey, and A. El Hasnaoui, Epidemiology of restless legs syndrome in French adults: a nationwide survey: the INSTANT Study. Neurology, 2005;65(2):239–246.PubMedCrossRefGoogle Scholar
  21. 21.
    Nichols, D.A., R.P. Allen, J.H. Grauke, et al., Restless legs syndrome symptoms in primary care: a prevalence study. Arch Intern Med, 2003;163(19):2323–2329.PubMedCrossRefGoogle Scholar
  22. 22.
    Polo-Kantola, P. and R. Erkkola, Sleep and the menopause. J Br Menopause Soc, 2004;10(4):145–150.PubMedCrossRefGoogle Scholar
  23. 23.
    Chaudhuri, K.R., A. Forbes, D. Grosset, et al., Diagnosing restless legs syndrome (RLS) in primar care. Curr Med Res Opin, 2004;20(11):1785–1795.PubMedCrossRefGoogle Scholar
  24. 24.
    Sukegawa, T., M. Itoga, H. Seno, et al., Sleep disturbances and depression in the elderly in Japan. Psychiatry Clin Neurosci, 2003;57(3):265–270.PubMedCrossRefGoogle Scholar
  25. 25.
    Stiasny-Kolster, K., C. Trenkwalder, W. Fogel, et al., Restless legs syndrome-new insights into clinical characteristics, pathophysiology, and treatment options. J Neurol, 2004. 251(Suppl 6):VI/39-VI/43.Google Scholar
  26. 26.
    Moline, M., L. Broch, and R. Zak, Sleep problems across the life cycle in women. Curr Treat Options Neurol, 2004;6(4):319–330.PubMedCrossRefGoogle Scholar
  27. 27.
    Garcia-Borreguero, D., C. Serrano, O. Larrosa, and J.J. Granizo, Circadian variation in neuroendocrine response to L-dopa in patients with restless legs syndrome. Sleep, 2004;27(4):669–673.PubMedGoogle Scholar
  28. 28.
    Michaud, M., J.P. Soucy, A. Chabli, G. Lavigne, and J. Montplaisir, SPECT imaging of striatal pre-and postsynaptic dopaminergic status in restless legs syndrome with periodic leg movements in sleep. J Neurol, 2002;249(2):164–1670.PubMedCrossRefGoogle Scholar
  29. 29.
    Erikson, K.M., B.C. Jones, and J.L. Beard, Iron deficiency alters dopamine transporter functioning in rat striatum. J Nutr, 2000;130(11):2831–2837.PubMedGoogle Scholar
  30. 30.
    Connor, J.R., P.J. Boyer, S.L. Menzies, et al., Neuropathological examination suggests impaired brain iron acquisition in restless legs syndrome. Neurology, 2003;61(3):304–309.PubMedGoogle Scholar
  31. 31.
    Lee, K.A., M.E. Zaffke, and K. Baratte-Beebe, Restless legs syndrome and sleep disturbance during pregnancy: the role of folate and iron. J Womens Health Gend Based Med, 2001;10(4):335–341.PubMedCrossRefGoogle Scholar
  32. 32.
    Earley, C.J., D. Heckler, and R.P. Allen, Repeated IV doses of iron provides effective supplemental treatment of restless legs syndrome. Sleep Med, 2005;6(4):301–305.PubMedCrossRefGoogle Scholar
  33. 32a.
    Moyer, P., Compromised brain iron abnormalities linked to early-onset restless legs syndrome. Neurology Today, 2005;489.Google Scholar
  34. 33.
    Manconi, M., V. Govoni, A. De Vito, et al., Restless legs syndrome and pregnancy. Neurology, 2004;63(6):1065–1069.PubMedGoogle Scholar
  35. 34.
    Rijsman, R., A.K. Neven, W. Graffelman, B. Kemp, and A. de Weerd, Epidemiology of restless legs in The Netherlands. Eur J Neurol, 2004;11(9):607–611.PubMedCrossRefGoogle Scholar
  36. 35.
    Polo-Kantola, P., M. Dumont, J. Paquet, A. Desautels, M.L. Fantini, and J. Montplaisir, Estrogen replacement therapy and nocturnal periodic limb movements: a randomized controlled trial. Obstet Gynecol, 2001;97(4):548–554.PubMedCrossRefGoogle Scholar
  37. 36.
    Manconi, M., M. Dumont, B. Selmaoui, J. Paquet, M.L. Fantini, and J. Montplaisir, Pregnancy as a risk factor for restless legs syndrome. Sleep Med, 2004;5(3):305–308.PubMedCrossRefGoogle Scholar
  38. 37.
    Eichling, P. and J. Sahni, Menopause related sleep disorders. J Clin Sleep Med, 2005;1(3):291–300.PubMedGoogle Scholar
  39. 37a.
    Jourdain, S., M. Morissette, N. Morin, and T. Di Paolo, Oestrogens prevent loss of dopamine transporter (DAT) and vesicular monoamine transporter (VMAT2) is substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice. J Neuroendocrinol, 2005;17(8):509–517.PubMedCrossRefGoogle Scholar
  40. 37b.
    Genazzani, A.R., F. Bernardi, N. Pluchino, et al., Endocrinology of menopausal transition and its brain implications. CNS Spectr, 2005;10(6):449–457.PubMedGoogle Scholar
  41. 38.
    Michaud, M., E. Rauhala, R. Erkkola, K. Irjala, and O. Polo, Circadian variation of the effects of immobility on symptoms of restless legs syndrome. Sleep, 2005;28(7):843–846.PubMedGoogle Scholar
  42. 39.
    Michaud, M., V. Govoni, A. De Vito, et al., Circadian rhythm of restless legs syndrome: relationship with biological markers. Ann Neurol, 2004;55(3):372–380.PubMedCrossRefGoogle Scholar
  43. 40.
    Okatani, Y., N. Morioka, and A. Wakatsuki, Changes in nocturnal melatonin secretion in perimenopausal women: correlation with endogenous estrogen concentrations. J Pineal Res, 2000;28(2):111–118.PubMedCrossRefGoogle Scholar
  44. 41.
    Zeitzer, J.M., J.E. Daniels, J.F. Duffy, Do plasma melatonin concentrations decline with age? Am J Med, 1999;107(5):432–436.PubMedCrossRefGoogle Scholar
  45. 42.
    Fernandez, B., J.L. Malde, A. Montero, and D. Acuna, Relationship between adenohypophyseal and steroid hormones and variations in serum and urinary melatonin levels during the ovarian cycle, perimenopause and menopause in healthy women. J Steroid Biochem, 1990;35(2):257–262.PubMedCrossRefGoogle Scholar

Copyright information

© Humana Press Inc., Totowa, NJ 2006

Authors and Affiliations

  • Nancy S. Collins
    • 1
  1. 1.Department of NeurologyNorth Chicago

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