Skip to main content

The Medicolegal Evaluation of Excited Delirium

  • Chapter
Forensic Pathology Reviews

Part of the book series: Forensic Pathology Reviews ((FPR,volume 5))

Abstract

Excited delirium is a life-threatening syndrome that may be initiated by a variety of causes including drug intoxications and psychiatric illnesses. People in an excited delirium may demonstrate paranoid, aggressive, and incoherent behavior. Due to their actions, people in an excited delirium may come to the attention of law enforcement. The challenge for the forensic pathologist arises when these deaths occur during or shortly following a violent struggle, often involving law enforcement agents. Three instances of excited delirium are described to demonstrate further the syndrome and to serve as a basis for the discussion of the medicolegal aspects of excited delirium. There are several theories for this syndrome and much attention has been given to the role of restraint and struggle. In addition to asphyxial mechanisms, other neurochemical abnormalities involving dopamine, elevated potassium concentrations, lactic acidosis, and increased catecholamine effects on the heart have been examined. Cocaine and amphetamine are two of many substances that may cause the syndrome of excited delirium. The goal of the autopsy in suspected excited delirium deaths is to identify (or exclude) a disease or injury sufficient to explain a sudden death in the context of the investigated circumstances. In deaths due to excited delirium, there is no pathognomonic autopsy finding and minor injuries (abrasions, contusions, cuts) are typical. Due to the complex physiologic, chemical, environmental, and traumatic interactions that occur, there is perhaps no other type of death in which it is so important to apply the forensic maxim that each death must be evaluated “one at a time”. The roles of restraint, electromuscular disruption devices (e.g., Tasers®), mechanical trauma, stress, and natural disease must be considered in the certification of death.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Brown TM, Boyle MF (2002) Delirium. BMJ 325:644–647

    Article  PubMed  CAS  Google Scholar 

  2. Wetli C (2005) Excited delirium. In: Payne-James J, Byard RW, Corey TS, Henderson C (eds) Encyclopedia of forensic and legal medicine. Elsevier Academic Press, Amsterdam, pp 276–281

    Chapter  Google Scholar 

  3. DiMaio TG, DiMaio JM (2006) Excited delirium syndrome, 1st edn. CRC, Boca Raton, FL

    Google Scholar 

  4. Raval MP, Welti CV (1995) Sudden death from cocaine induced excited delirium: 45 cases (abstract). Am J Clin Pathol 104:329

    Google Scholar 

  5. Wetli CV, Fishbain DA (1985) Cocaine-induced psychosis and sudden death in recreational cocaine users. J Forensic Sci 30:873–880

    PubMed  CAS  Google Scholar 

  6. Wetli CV, Mash D, Karch SB (1996) Cocaine-associated agitated delirium and the neuroleptic malignant syndrome. Am J Emerg Med 14:425–428

    Article  PubMed  CAS  Google Scholar 

  7. Ross D (1998) Factors associated with excited delirium deaths in police custody. Mod Pathol 11:1127–1137

    PubMed  CAS  Google Scholar 

  8. Ruttenber AJ, McAnally HB, Wetli CV (1999) Cocaine-associated rhabdomyolysis and excited delirium: different stages of the same syndrome. Am J Forensic Med Pathol 20:120–127

    Article  PubMed  CAS  Google Scholar 

  9. Stratton SJ, Rogers C, Brickett K, Gruzinski G (2001) Factors associated with sudden death of individuals requiring restraint for excited delirium. Am J Emerg Med 19:187–191

    Article  PubMed  CAS  Google Scholar 

  10. Hayes J (1991) Sudden death during excited delirium, etiology unknown. ASCP Check Sample 91-5 (FP-178), pp 1–7

    Google Scholar 

  11. Ruttenber AJ, Lawler-Heavner J, Yin M et al. (1997) Fatal excited delirium following cocaine use: epidemiologic findings provide new evidence for mechanisms of cocaine toxicity. J Forensic Sci 42:25–31

    PubMed  CAS  Google Scholar 

  12. Karch S (2002) The pathology of drug abuse, 3rd edn. CRC Press, Boca Raton, FL

    Google Scholar 

  13. Fishbain DA, Wetli CV (1981) Cocaine intoxication, delirium, and death in a body packer. Ann Emerg Med 10:531–532

    Article  PubMed  CAS  Google Scholar 

  14. Steffee CH, Lantz PE, Flannagan LM, Thompson RL, Jason DR (1995) Oleoresin capsicum (pepper) spray and “in-custody deaths”. Am J Forensic Med Pathol 16:185–192

    Article  PubMed  CAS  Google Scholar 

  15. Reay DT, Eisele JW (1982) Death from law enforcement neck holds. Am J Forensic Med Pathol 3:253–258

    Article  PubMed  CAS  Google Scholar 

  16. Lifschultz BD, Donoghue ER (1991) Deaths in custody. Leg Med 45–71

    Google Scholar 

  17. Kornblum RN, Reddy SK (1991) Effects of the Taser in fatalities involving police confrontation. J Forensic Sci 36:434–438

    PubMed  CAS  Google Scholar 

  18. Luke J, Reay D (1992) The perils of investigating and certifying deaths in police custody. Am J Forensic Med Pathol 13:98–100

    Article  PubMed  CAS  Google Scholar 

  19. Allam S, Noble JS (2001) Cocaine-excited delirium and severe acidosis. Anaesthesia 56:385–386

    Article  PubMed  CAS  Google Scholar 

  20. Pollanen MS, Chiasson DA, Cairns JT, Young JG (1998) Unexpected death related to restraint for excited delirium: a retrospective study of deaths in police custody and in the community. CMAJ 158:1603–1607

    PubMed  CAS  Google Scholar 

  21. O'Halloran RL, Lewman LV (1993) Restraint asphyxiation in excited delirium. Am J Forensic Med Pathol 14:289–295

    Article  PubMed  Google Scholar 

  22. Karch SB, Wetli CV (1995) Agitated delirium versus positional asphyxia. Ann Emerg Med 26:760–761

    Article  PubMed  CAS  Google Scholar 

  23. Laposata EA (1993) Positional asphyxia during law enforcement transport. Am J Forensic Med Pathol 14:86–87

    Article  PubMed  CAS  Google Scholar 

  24. Farnham FR, Kennedy HG (1997) Acute excited states and sudden death. BMJ 315:1107–1108

    PubMed  CAS  Google Scholar 

  25. Pounder D (1998) Acute excited states and sudden death. Death after restraint can be avoided. BMJ 316:1171

    PubMed  CAS  Google Scholar 

  26. Stratton SJ, Rogers C, Green K (1995) Sudden death in individuals in hobble restraints during paramedic transport. Ann Emerg Med 25:710–712

    Article  PubMed  CAS  Google Scholar 

  27. Jauchem J, Sherry C, Fines D, Cook M (2006) Acidosis, lactate, electrolytes, muscle enzymes, and other factors in the blood of Sus scrofa following repeated Taser exposures. Forensic Sci Int 161:20–30

    Article  PubMed  CAS  Google Scholar 

  28. Ho JD, Miner JR, Lakireddy DR, Bultman LL, Heegaard WG (2006) Cardiovascular and physiologic effects of conducted electrical weapon discharge in resting adults. Acad Emerg Med 13:589–595

    Article  PubMed  Google Scholar 

  29. Rosh A, Sampson BA, Hirsch CS (2003) Schizophrenia as a cause of death. J Forensic Sci 48:164–167

    PubMed  Google Scholar 

  30. Marzuk P, Tardiff K, Leon A et al. (1998) Ambient temperature and mortality from unintentional cocaine overdose. JAMA 279:1795–1800

    Article  PubMed  CAS  Google Scholar 

  31. Park KS, Korn CS, Henderson SO (2001) Agitated delirium and sudden death: two case reports. Prehosp Emerg Care 5:214–216

    Article  PubMed  CAS  Google Scholar 

  32. Mirchandani HG, Rorke LB, Sekula-Perlman A, Hood IC (1994) Cocaine-induced agitated delirium, forceful struggle, and minor head injury. A further definition of sudden death during restraint. Am J Forensic Med Pathol 15:95–99

    Article  PubMed  CAS  Google Scholar 

  33. Karch SB, Stephens BG (1998) Acute excited states and sudden death. Acute excited states are not caused by high blood concentrations of cocaine. BMJ 316:1171

    PubMed  CAS  Google Scholar 

  34. Hirsch CS (1994) Restraint asphyxiation [letter]. Am J Forensic Med Pathol 15:266

    Article  PubMed  CAS  Google Scholar 

  35. O'Halloran RL, Frank JG (2000) Asphyxial death during prone restraint revisited: a report of 21 cases. Am J Forensic Med Pathol 21:39–52

    Google Scholar 

  36. Reay DT, Howard JD, Fligner CL, Ward RJ (1988) Effects of positional restraint on oxygen saturation and heart rate following exercise. Am J Forensic Med Pathol 9:16–18

    Article  PubMed  CAS  Google Scholar 

  37. Reay D, Fligner C, Stilwell A, Arnold J (1992) Positional asphyxia during law enforcement transport. Am J Forensic Med Pathol 13:90–97

    Article  PubMed  CAS  Google Scholar 

  38. Chan TC, Vilke GM, Neuman T, Clausen JL (1997) Restraint position and positional asphyxia. Ann Emerg Med 30:578–586

    Article  PubMed  CAS  Google Scholar 

  39. Chan TC, Neuman T, Clausen J, Eisele J, Vilke GM (2004) Weight force during prone restraint and respiratory function. Am J Forensic Med Pathol 25:185–189

    Article  PubMed  Google Scholar 

  40. Schmidt P, Snowden T (1999) The effects of positional restraint on heart rate and oxygen saturation. J Emerg Med 17:777–782

    Article  PubMed  CAS  Google Scholar 

  41. Roeggla M, Wagner A, Muellner M et al. (1997) Cardiorespiratory consequences to hobble restraint. Wein Klin Wochenschr 109:359–361

    Google Scholar 

  42. Reay DT, Howard JD (1999) Restraint position and positional asphyxia. Am J Forensic Med Pathol 20:300–301

    Article  PubMed  CAS  Google Scholar 

  43. Chan TC, Vilke GM, Neuman T (1998) Reexamination of custody restraint position and positional asphyxia. Am J Forensic Med Pathol 19:201–205

    Article  PubMed  CAS  Google Scholar 

  44. Ely SF, Hirsch CS (2000) Asphyxial deaths and petechiae: a review. J Forensic Sci 45:1274–1277

    PubMed  CAS  Google Scholar 

  45. DiMaio V, DiMaio D (2001) Forensic pathology, 2nd edn. CRC Press, Boca Raton, FL

    Google Scholar 

  46. Adelson L (1974) Pathology of homicide. Charles C Thomas, Springfield

    Google Scholar 

  47. Robinson MN, Brooks CG, Renshaw GD (1990) Electric shock devices and their effects on the human body. Med Sci Law 30:285–300

    PubMed  CAS  Google Scholar 

  48. Levine S, Sloane C, Chan T, Vilke G (2006) Cardiac monitoring of human subjects exposed to the Taser (abstract). Acad Emerg Med 13:S47

    Article  Google Scholar 

  49. Stratbucker R, Kroll M, McDaniel W, Panescu D (2006) Cardiac current density distribution by electrical pulses from Taser devices. Conf Proc IEEE Eng MED Biol Soc 1:6305–6307

    Google Scholar 

  50. Wu JY, Sun H, O’Rourke AP et al. (2007) Taser dart-to-heart distance that causes ventricular fibrillation in pigs. IEEE Trans Biomed Eng 54:503–508

    Google Scholar 

  51. Nanthakumar K, Masse S, Umapathy K et al. (2008) Cardiac stimulation with high voltage discharge from stun guns. CMAJ 178(II):1451–1457

    Google Scholar 

  52. Cao M, Shinbane JS, Gillberg JM, Saxon LA (2007) Taser-induced rapid ventricular myocardial capture demonstrated by pacemaker intracardiac electrograms. J Cardiovasc Electrophysiol 18:876–879

    Google Scholar 

  53. Spitz W (2006) Spitz and Fisher's medicolegal investigation of death, 4th edn. Charles C Thomas, Springfield

    Google Scholar 

  54. O'Brien DJ (1991) Electronic weaponry – a question of safety. Ann Emerg Med 20:583–587

    Article  PubMed  Google Scholar 

  55. Ruggieri J (2005) Forensic engineering analysis of electro-shock weapon safety. J Nat Acad Forensic Eng 23:19–48

    Google Scholar 

  56. Anglen R (2006) Study raises concerns over Taser's safety, The Arizona Republic, Phoenix, AZ

    Google Scholar 

  57. Yamaguchi G (2006) Letter on preliminary testing results on Taser M18, 2/3/06

    Google Scholar 

  58. Ordog GJ, Wasserberger J, Schlater T, Balasubramanium S (1987) Electronic gun (Taser) injuries. Ann Emerg Med 16:73–78

    Article  PubMed  CAS  Google Scholar 

  59. Davis JH (1978) Can sudden cardiac death be murder? J Forensic Sci 23:384–387

    PubMed  CAS  Google Scholar 

  60. Turner SA, Barnard JJ, Spotswood SD, Prahlow JA (2004) “Homicide by heart attack” revisited. J Forensic Sci 49:598–600

    Article  PubMed  Google Scholar 

  61. Pudiak CM, Bozarth MA (1994) Cocaine fatalities increased by restraint stress. Life Sci 55:PL379–382

    Google Scholar 

  62. Kock MD, Jessup DA, Clark RK, Franti CE, Weaver RA (1987) Capture methods in five subspecies of free-ranging bighorn sheep: an evaluation of drop-net, drive-net, chemical immobilization and the net-gun. J Wildl Dis 23:634–640

    PubMed  CAS  Google Scholar 

  63. Wittstein IS, Thiemann DR, Lima JA et al. (2005) Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med 352:539–548

    Article  PubMed  CAS  Google Scholar 

  64. Cebelin M, Hirsch C (1980) Human stress cardiomyopathy: myocardial lesions in victims of homicidal assaults without internal injuries. Hum Pathol 11:123–132

    Article  PubMed  CAS  Google Scholar 

  65. Carson JL, Kelley MA, Duff A et al. (1992) Clinical course of pulmonary embolism. N Engl J Med 326:1240–1245

    Article  PubMed  CAS  Google Scholar 

  66. Amnesty International (2004) United States of America: excessive and lethal force? Amnesty International’s concerns about deaths and ill-treatment involving police use of Tasers. 1-94 (report)

    Google Scholar 

  67. Kasper D, Braunwald E, Fauci A et al. (2004) Harrison's principles of internal medicine, 16th edn. McGraw-Hill Professional, New York

    Google Scholar 

  68. Meagher DJ (2001) Delirium: optimising management. BMJ 322:144–149

    Article  PubMed  CAS  Google Scholar 

  69. Zun LS (2003) A prospective study of the complication rate of use of patient restraint in the emergency department. J Emerg Med 24:119–124

    Article  PubMed  Google Scholar 

  70. Chan TC, Vilke GM, Clausen J et al. (2002) The effect of oleoresin capsicum “pepper” spray inhalation on respiratory function. J Forensic Sci 47:299–304

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Humana Press, a part of Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Gill, J.R. (2009). The Medicolegal Evaluation of Excited Delirium. In: Tsokos, M. (eds) Forensic Pathology Reviews. Forensic Pathology Reviews, vol 5. Humana Press. https://doi.org/10.1007/978-1-59745-110-9_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-59745-110-9_6

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-832-4

  • Online ISBN: 978-1-59745-110-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics