Neuromuscular disease refers to any genetic, metabolic, or acquired dysfunction intrinsic to nerve or muscle. A motor unit (Fig. 1) is the smallest functional unit of the motor system and consists of a motor neuron, its axon, and all the muscle fibers innervated by the axon. Neuromuscular disease can be organized as the study of pathologies affecting one of the following four parts of the anatomic nerve-muscle cascade:
Diseases of the motor neuron.
Diseases of peripheral nerves (peripheral neuropathies).
Neuromuscular junction disorders.
Disorders of muscle (myopathies).
KeywordsSpinal Muscular Atrophy Motor Neuron Disease Myotonic Dystrophy Lower Motor Neuron Anterior Horn Cell
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Key References and Suggested Additional Reading
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